Hostname: page-component-586b7cd67f-tf8b9 Total loading time: 0 Render date: 2024-11-27T14:12:35.507Z Has data issue: false hasContentIssue false
  • English
  • Français

Cerebral Blood Flow in Patients with Intracranial Pressure Elevation due to Traumatic Brain Edema

Published online by Cambridge University Press:  18 September 2015

W. A. Tweed  and
Jørn Overgaard
W. A. Tweed*
Affiliation:
Department of Anesthesia, Health Sciences Centre (General), Winnipeg, Canada and Odense University Hospital, DK 5000, Odense, Denmark
Jørn Overgaard
Affiliation:
Department of Anesthesia, Health Sciences Centre (General), Winnipeg, Canada and Odense University Hospital, DK 5000, Odense, Denmark
*
Department of Anaesthesia, Health Science Centre, National Institutes of Health, 700 William Ave., Canada, R3E 0Z3
Rights & Permissions [Opens in a new window]

Summary:

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The object of this study was to determine if traumatic brain edema (BE) and increased intracranial pressure (ICP) reduce cerebral blood flow (CBF). Two groups of patients were studied, one with slight BE and ICP less than 20 mm Hg., the other with pronounced BE and ICP over 20 mm Hg. Although ICP was higher and cerebral perfusion pressure lower in pro-nounced edema there was only a small and non-significant reduction in CBF and no difference in cerebro-vascular resistance. Since traumatic BE does not increase resistance to blood flow through the brain, cerebral perfusion can be maintained if an adequate perfusion pressure is established. This in turn, demands the monitoring and control of ICP.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 3 , Issue 1 , February 1976 , pp. 35 - 37
Copyright
Copyright © Canadian Neurological Sciences Federation 1976

References

REFERENCES

Bruce, D.A., Langfitt, T.W., Miller, J.D., Schutz, H., Vapalahti, M.P., Stanek, A., Goldberg, I.H., (1973). Regional cerebral blood flow, intracranial pressure, and brain metabolism in comatose patients. J. Neurosurg. 38, 131–144.CrossRefGoogle ScholarPubMed
Feigin, L., Popoff, N., (1962). Neuropathological observations on cerebral edema. Arch. Neurol. 6, 151–160.CrossRefGoogle ScholarPubMed
Klatzo, I., “Pathophysiological aspects of brain edema.” In: Steroids and Brain Edema. Reulen, H.J. and Schiirmann, K., eds., New york: Springer Verlag (1972).Google Scholar
Marshall, W.J.S., Jackson, J.L.F., and Langfitt, T.W., (1969). Brain swelling caused by trauma and arterial hypertension: hemodynamic aspects. Arch. Neurol. 21, 545–553.CrossRefGoogle ScholarPubMed
Meinig, G., Reulen, H.J., Hadjidimos, A., Siemon, C, Bartho, D., and Schurmann, K., (1972). Induction of filtration edema by extreme reduction of cerebrovascular resistance associated with hypertension. European Neurol. 8, 97–103.CrossRefGoogle ScholarPubMed
Olesen, J., Paulson, O.B., and Lassen, N.A., (1971). Regional cerebral blood flow in man determined by the initial slope of the clearance of intra-arterially injected 133 Xe. Stroke 2, 519–540.CrossRefGoogle Scholar
Overgaard, , Jorn, , Tweed, W.A., (1974). Cerebral circulation after head injury: Part 1. J. Neurosurg. 41, 531–541.CrossRefGoogle ScholarPubMed
Rowan, J.O., Johnston, I.H., Harper, A.M., and Jennet, W.B., Perfusion pressure in intracranial hypertension. In Intracranial Pressure, Edited by Brock, M. and Dietz, H., Springer Verlag, 1972, Page 165.CrossRefGoogle Scholar
Tweed, W.A., and Overgaard, J., Disturbed regulation of CBF after acute brain injury with particular reference to the effects on MIVP and CPP. In Cerebral Circulation and Metabolism, Edited by Thomas, W.Langfitt, , Lawrence, C.Jr.McHenry, , Martin Reivich and Harry Wollman, Springer-Verlag, 1975. Page 249.Google Scholar