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Cataleptic Effect of 61-91 Beta-Lipotropic Hormone in Rat

Published online by Cambridge University Press:  03 July 2018

T. Motomatsu ,
M. Lis. N. Seidah  and
M. Chrétien
T. Motomatsu
Affiliation:
Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec
M. Lis. N. Seidah
Affiliation:
Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec
M. Chrétien*
Affiliation:
Clinical Research Institute of Montreal, 110 Pine Avenue West, Montreal, Quebec
*
Clinical Research Institute of Montreal, 110 Pine Avenue, West, Montréal H2W 1R7, Canada.
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Summary

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Intraventricular administration of a peptide from ovine pituitaries whose structure is identical to the 61-91 C-terminal portion of beta-lipotropic hormone (61-91 beta-LPH) induced catalepsy, muscular hypertonus and analgesia in rats. Naloxone inhibited both the analgesic and cataleptic effects. l-dihydroxyphenylalanine (l-DOPA) completely prevented the cataleptic effect. The cataleptic effect of 61-91 beta-LPH was potentiated by 1-5-hydroxytryptophan (5-HTP).

Résumé

Résumé

L’administration intraventriculaire d’un peptide isolé d’hypophyses de mouton, peptide dont la structure est identique au fragment carboxy-terminal 61-91 de la béta-lipotropine produit de la catalepsie, de l’hypertonie musculaire et de l’analgésie chez le rat. La naloxone inhibe les effets analgésiques et cataleptiques. La l-dihydroxyphenylalanine (l-DOPA) a prévenu totalement l’effet cataleptique. Celui-ci était par contre potentialisé par du l-5-hydroxytryptophane (5-HTP).

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 4 , Issue 1 , February 1977 , pp. 49 - 52
Copyright
Copyright © Canadian Neurological Sciences Federation 1977

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