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Bromocriptine in the Management of End of Dose Deterioration in Parkinson’s Disease

Published online by Cambridge University Press:  18 September 2015

J.D. Grimes ,
D.B. King ,
O.S. Kofman ,
P. Molina-Negro ,
A.F. Wilson  and
S. Bouchard
J.D. Grimes*
Affiliation:
the Ottawa Civic Hospital (Dr. Grimes); Victoria General Hospital, Halifax (Dr. King); Mount Sinai Hospital, Toronto (Dr. Kofman); Notre Dame Hospital, Montreal (Dr. Molina-Negro); Royal Alexandra Hospital, Edmonton (Dr. Wilson); Sandoz Canada, Montreal (Dr. Bouchard)
D.B. King
Affiliation:
the Ottawa Civic Hospital (Dr. Grimes); Victoria General Hospital, Halifax (Dr. King); Mount Sinai Hospital, Toronto (Dr. Kofman); Notre Dame Hospital, Montreal (Dr. Molina-Negro); Royal Alexandra Hospital, Edmonton (Dr. Wilson); Sandoz Canada, Montreal (Dr. Bouchard)
O.S. Kofman
Affiliation:
the Ottawa Civic Hospital (Dr. Grimes); Victoria General Hospital, Halifax (Dr. King); Mount Sinai Hospital, Toronto (Dr. Kofman); Notre Dame Hospital, Montreal (Dr. Molina-Negro); Royal Alexandra Hospital, Edmonton (Dr. Wilson); Sandoz Canada, Montreal (Dr. Bouchard)
P. Molina-Negro
Affiliation:
the Ottawa Civic Hospital (Dr. Grimes); Victoria General Hospital, Halifax (Dr. King); Mount Sinai Hospital, Toronto (Dr. Kofman); Notre Dame Hospital, Montreal (Dr. Molina-Negro); Royal Alexandra Hospital, Edmonton (Dr. Wilson); Sandoz Canada, Montreal (Dr. Bouchard)
A.F. Wilson
Affiliation:
the Ottawa Civic Hospital (Dr. Grimes); Victoria General Hospital, Halifax (Dr. King); Mount Sinai Hospital, Toronto (Dr. Kofman); Notre Dame Hospital, Montreal (Dr. Molina-Negro); Royal Alexandra Hospital, Edmonton (Dr. Wilson); Sandoz Canada, Montreal (Dr. Bouchard)
S. Bouchard
Affiliation:
the Ottawa Civic Hospital (Dr. Grimes); Victoria General Hospital, Halifax (Dr. King); Mount Sinai Hospital, Toronto (Dr. Kofman); Notre Dame Hospital, Montreal (Dr. Molina-Negro); Royal Alexandra Hospital, Edmonton (Dr. Wilson); Sandoz Canada, Montreal (Dr. Bouchard)
*
Suite 304, 1081 Carling Ave., Ottawa, Ontario, Canada K1Y 4G2
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Abstract

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Thirty-three patients with advanced Parkinson’s disease complicated by end of dose deterioration were treated with bromocriptine. The drug was slowly increased so that by treatment week 24 the mean daily dose of bromocriptine was 22mg and levodopa had been decreased by an average of 15 percent. The majority of improvement in daily fluctuations and Parkinsonian disability score was documented by 8 weeks, at which time the mean daily bromocriptine dose was only 12mg.

End of dose deterioration was reduced in 78 percent of the patients (mean 43% improvement). Total Parkinsonian disability score was decreased by 33 percent. Adverse effects were minimal; the most common was mild transient early treatment nausea which occurred in 15 percent of the patients.

The slow introduction of small doses of bromocriptine, combined with minimal levodopa reduction, can give Parkinsonian patients significant improvement in end of dose deterioration.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 11 , Issue 4 , November 1984 , pp. 452 - 456
Copyright
Copyright © Canadian Neurological Sciences Federation 1984

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