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Brain Neurotransmitter Receptors in Friedreich's Ataxia

Published online by Cambridge University Press:  18 September 2015

I. D. Reisine ,
J. Azari ,
P.C. Johnson ,
A. Barbeau ,
R. Huxtable  and
H.I. Yamamura
I. D. Reisine
Affiliation:
Departments of Pharmacology and Pathology, College of Medicine, University of Arizona Health Sciences Center, Tucson and the Department of Neurobiology, Clinical Research Institute of Montreal
J. Azari
Affiliation:
Departments of Pharmacology and Pathology, College of Medicine, University of Arizona Health Sciences Center, Tucson and the Department of Neurobiology, Clinical Research Institute of Montreal
P.C. Johnson
Affiliation:
Departments of Pharmacology and Pathology, College of Medicine, University of Arizona Health Sciences Center, Tucson and the Department of Neurobiology, Clinical Research Institute of Montreal
A. Barbeau
Affiliation:
Departments of Pharmacology and Pathology, College of Medicine, University of Arizona Health Sciences Center, Tucson and the Department of Neurobiology, Clinical Research Institute of Montreal
R. Huxtable
Affiliation:
Departments of Pharmacology and Pathology, College of Medicine, University of Arizona Health Sciences Center, Tucson and the Department of Neurobiology, Clinical Research Institute of Montreal
H.I. Yamamura
Affiliation:
Departments of Pharmacology and Pathology, College of Medicine, University of Arizona Health Sciences Center, Tucson and the Department of Neurobiology, Clinical Research Institute of Montreal
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Summary

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The binding of ‘H-quinu-clidinyl henzilate. a muscarinic cholinergic antagonist, of xH-dihydroalprenolol, a beta adrenergic antagonist, and of ﹜H-flunitrazepam, a ligand which labels benzodiazepine receptors, was examined in several regions of control and Fried-retch's ataxia (FA) brains. yH-Quinuclidi-nyl henzilate binding appeared to increase in the inferior olivory nucleus, anterior and posterior cerebellar vermi but was unaltered m the dentate nucleus and cerebellar hemisphere of FA brain. The binding of 1 H-dihydroalprenolol seemed to increase in the inferior olivary nucleus yet was not different from controls in the dentate nucleus, cerebellar hemisphere, anterior and posterior cerebellar vermi of FA brains. * H-Flunitrazepam binding was slightly lowered in the inferior olivary and dentate nuclei but was unchanged in the other FA brain regions examined. The present study suggests possible trends in neurotransmitter receptor alterations in post-mortem brain tissue of FA patients.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 6 , Issue 2 , May 1979 , pp. 259 - 262
Copyright
Copyright © Canadian Neurological Sciences Federation 1979

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