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Biochemical Markers for Huntington's Chorea

Published online by Cambridge University Press:  18 September 2015

D.R. McLean  and
T. Nihei
D.R. McLean*
Affiliation:
Division of Neurology, Faculty of Medicine, University of Alberta, Edmonton
T. Nihei
Affiliation:
Division of Neurology, Faculty of Medicine, University of Alberta, Edmonton
*
9-101 Clinical Sciences Building, The University of Alberta, Edmonton, Alberta, Canada T6G 2G3
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The uptake of dopamine (DA) by platelet rich plasma was assayed in 11 patients with Huntington's chorea (H. C). The results confirmed the previous observation that platelets from H.C. patients take up, at equilibrium, more dopamine than do platelets from normal control subjects. The mean difference was 50% higher at DA substrate concentrations of 0.11 mM.

However, attempts to confirm the higher Na+ - K+ ATPase activity of erythrocyte ghosts from Huntington's chorea patients were unsuccessful.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 7 , Issue 4 , November 1980 , pp. 281 - 283
Copyright
Copyright © Canadian Neurological Sciences Federation 1980

References

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