Hostname: page-component-5cf477f64f-54txb Total loading time: 0 Render date: 2025-04-03T07:24:37.570Z Has data issue: false hasContentIssue false
  • English
  • Français

The Association between Polycystic Kidney Disease and Cerebral Aneurysms

Published online by Cambridge University Press:  18 September 2015

Michael G. Fehlings  and
Fred Gentili
Michael G. Fehlings
Affiliation:
Division of Neurosurgery, The Toronto Hospital, Western Division and University of Toronto, Toronto
Fred Gentili*
Affiliation:
Division of Neurosurgery, The Toronto Hospital, Western Division and University of Toronto, Toronto
*
Division of Neurosurgery, The Toronto Hospital, Western Division, 399 Bathurst St, Toronto, Ontario, Canada M5T 2S8
Rights & Permissions [Opens in a new window]

Abstract:

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Rupture of cerebral aneurysms is an important cause of morbidity and mortality in patients with adult polycystic kidney disease (PKD). In the present paper, we review the literature regarding the association of cerebral aneurysms and PKD and emphasize, by means of a case report, the importance of familial clustering of aneurysms in patients with PKD. We conclude that the prevalence of intracranial aneurysms in patients with PKD approaches 40% and is likely significantly higher in patients with PKD and a positive family history for cerebral aneurysm. We recommend that screening cerebral angiography be strongly considered in all patients with PKD and a family history of cerebral aneurysm or subarachnoid hemorrhage.

Type
Articles
Information
Canadian Journal of Neurological Sciences , Volume 18 , Issue 4 , November 1991 , pp. 505 - 509
Copyright
Copyright © Canadian Neurological Sciences Federation 1991

References

REFERENCES

1.Hadfield, PM, Pfister, RC. Adult polycystic disease of kidneys (Potter Type 3). JAMA 1972; 222: 1527–1531.CrossRefGoogle Scholar
2.Levey, AS, Pauker, SG, Kassirer, JP. Occult intracranial aneurysms in polycystic kidney disease. When is cerebral arteriography indicated? N Eng J Med 1983; 308: 986–994.CrossRefGoogle ScholarPubMed
3.Wakabayashi, T, Fujita, S, Ohbora, Y, et al.Polycystic kidney disease and intracranial aneurysms. Early angiographic diagnosis andearly operation for the unruptured aneurysm. J Neurosurg 1983; 58: 488–491.CrossRefGoogle Scholar
4.Saifuddin, A, Dathan, JRE. Adult polycystic kidney disease and intracranial aneurysms. Brit Med J 1987; 295: 526.Google Scholar
5.Stehbens, WE. Cerebral aneurysms and congenital abnormalities. Aust Ann Med 1962; 11: 101–112.Google ScholarPubMed
6.Stehbens, WE. Etiology of intracranial berry aneurysms. J Neurosurg 1989; 70: 823–831.CrossRefGoogle ScholarPubMed
7.Suter, W.Das kongenitale Aneurysma der basalen Gehirnarterien und Cystennieren. Schweiz Med Wochneschr 1949; 79: 471–476.Google Scholar
8.Borelius, J.Zur Genese und klinischen Diagnose der polycystischen Degeneration der Nieren. Nord Med Ark 1901; 34 (Afd 1; Nr 27): 1–21.Google Scholar
9.Dunger, R.Zur Lehre von der Cystenniere, mit besonderer Berucksichtigung ihrere Hereditat. Beitr Pathol 1904,35: 445–509.Google Scholar
10.Brown, RAP. Polycystic disease of the kidneys and intracranial aneurysms: the etiology and interrelationship of these conditions: review of recent literature and report of seven cases in which both conditions coexisted. Glasgow Med J 1951; 32: 333–348.Google ScholarPubMed
11.Bigelow, NH. The association of polycystic kidneys with intracranial aneurysms and other related disorders. Am J Med Sci 1953; 225: 485–494.CrossRefGoogle ScholarPubMed
12.Dalgaard, OZ. Bilateral polycystic disease of the kidneys: a followup of two hundred and eighty-four patients and their families. Acta Med Scand (Suppl.) 1957; 328: 1–251.Google ScholarPubMed
13.Ditlefsen, EML, Tonjum, AM. Intracranial aneurysm and polycystic kidneys. Acta Med Scand 1960; 168: 51–54.CrossRefGoogle ScholarPubMed
14.Lazarus, JM, Bailey, GL, Hampers, CL, et al. Hemodialysis and transplantation in adults with polycystic renal disease. JAMA 1971; 217: 1821–1824.CrossRefGoogle ScholarPubMed
15.Matsumura, M, Wada, H, Nojiri, K.Unruptured intracranial aneurysms in polycystic kidney disease. Acta Neurochir 1986; 79: 94–99.CrossRefGoogle ScholarPubMed
16.Kaehny, W, Bell, P, Earnest, M, et al. Familial clustering of intracranial aneurysms in autosomal dominant polycystic kidney disease. Abstract from American Society of Nephrology. Kidney Int 1987; 31: 204.Google Scholar
17Lozano, AM, Leblanc, R.Familial intracranial aneurysms. J Neurosurg 1987; 66: 522–528.CrossRefGoogle ScholarPubMed
18Pope, FM, Nicholls, AC, Narcisi, P, et al. Some patients with cerebral aneurysms are deficient in Type III collagen. Lancet 1981; 1: 973–975.CrossRefGoogle ScholarPubMed