Hostname: page-component-586b7cd67f-r5fsc Total loading time: 0 Render date: 2024-11-30T15:17:51.817Z Has data issue: false hasContentIssue false

Association Between Alzheimer Disease and Amyotrophic Lateral Sclerosis?

Published online by Cambridge University Press:  18 September 2015

M.F. Frecker*
Affiliation:
Division of Neurology, Faculty of Medicine, Memorial University, St. John's, Newfoundland
F.C Fraser
Affiliation:
Centre for Human Genetics, McGill University, Montreal
E. Andermann
Affiliation:
Centre for Human Genetics, McGill University, Montreal Neurogenetics Unit, Montreal Neurological Hospital and Institute, Montreal
W.E.M. Pryse-Phillips
Affiliation:
Division of Neurology, Faculty of Medicine, Memorial University, St. John's, Newfoundland
*
Division of Neurology, Faculty of Medicine, Memorial University, St. John's, Newfoundland, Canada AlB 3V6
Rights & Permissions [Opens in a new window]

Abstract:

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

We report two cases of Alzheimer disease (AD) — one of them familial — in which the patient also had amyotrophic lateral sclerosis (ALS), and one patient with familial AD who had a son with ALS. Three further cases of probable ALS were found in pedigrees of AD reported from the literature. It is proposed that this association is not coincidental, but may suggest an etiological factor in common.

Type
Original Articles
Copyright
Copyright © Canadian Neurological Sciences Federation 1990

References

REFERENCES

1.Ditter, SM, Mirra, SS.Neuropathologic and clinical features of Parkinson’s disease in Alzheimer’s disease patients. Neurology 1987; 37: 754760.CrossRefGoogle ScholarPubMed
2.Anderson, FH, Richardson, EP, Okazaki, H, et al. Neurofibrillary degeneration on Guam: frequency in Chamorros and non Chamorros with no known neurological disease. Brain 1979; 102: 6577.CrossRefGoogle ScholarPubMed
3.Appel, SH.A unifying hypothesis for the cause of amyotrophic lateral sclerosis, parkinsonism and Alzheimer disease. Ann Neurol 1981; 10: 499505.CrossRefGoogle ScholarPubMed
4.Gajdusek, DC.Hypothesis: interference with axonal transport of neurofilament as a common pathogenic mechanism in certain diseases of the central nervous system. N Engl J Med 1985; 312: 714719.CrossRefGoogle Scholar
5.Calne, DB, Mcgeer, E,Eisen, A, et al. Alzeimer’s disease, Parkinson’s disease and motoneuron disease: abiotrophic interaction between aging and environment?. Lancet 1986; 2: 10671070.CrossRefGoogle Scholar
6.Siddique, T.Personal communication.Google Scholar
7.Heston, LL, White, J.Pedigrees of 30 families with Alzheimer disease: associations with defective organization of microfilaments and microtubules. Behavior Gen 1978; 8: 315331.CrossRefGoogle ScholarPubMed
8.Goudsmit, J, White, BWeitkamp, LRet al. Familial Alzheimer’s disease in two kindreds of the same geographic and ethnic origin. J Neurol Sci 1981; 49: 7989.CrossRefGoogle ScholarPubMed
9.St George-Hyslop, PH, Tanzi, REPolinsky, RJ, et al. The genetic defect causing familial Alzheimer’s disease maps on chromosome. Science 1987; 235: 885890.CrossRefGoogle ScholarPubMed
10.Kurtzke, JF.Epidemiology of amyotrophic lateral sclerosis. In: Rowland, LP, ed. Human Motor Neuron Diseases New York: Raven Press 1982; 281302.Google Scholar
11.Hudson, AJ, Davenport, AHader, WJ.The incidence of amytrophic lateral sclerosis in southwestern Ontario, Canada. Neurology 1986; 36: 15241528.CrossRefGoogle ScholarPubMed
12.Mulder, DW, Kurland, LTOfford, KP, et al. Familial adult motor neuron disease: amyotrophic lateral sclerosis. Neurology 1986; 36: 511517.Google ScholarPubMed
13.Statistics Canada. Causes of Death. Cat No 84–203.1969–1985.Google Scholar
14.Pinsky, L, Finlayson, MHLibman, I, et al. Familial amyotrophic lateral sclerosis with dementia: a second Canadian family. Clin Gen 1975; 7: 186191.CrossRefGoogle ScholarPubMed