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Amyotrophic Lateral Sclerosis/Parkinsonism/Dementia: Clinico-Pathological Correlations Relevant to Guamanian ALS/PD

Published online by Cambridge University Press:  18 September 2015

Arthur J. Hudson
Arthur J. Hudson*
Affiliation:
Department of Clinical Neurological Sciencies, University of Western Ontario, London
*
University Hospital, 339 Windermere Road, London, Ontario, Canada N6A 5A5
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Abstract:

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In a recent report on the clinical and pathological features of Guamanian ALS/PD and post-encephalitic parkinsonism/ALS a number of similarities were described, notably in the distribution of neurofibrillary tangles throughout the nervous system. In this account additional pathological features which these disorders share (and which differ from classical ALS, Parkinson's and Alzheimer's diseases) are described. These include atrophy of the globus pallidus and the entire substantia nigra, viz. pars compacta and pars reticulata. Moreover, neither Lewy bodies nor senile plaques are features of the Guamanian and post-encephalitic disorders. The significance of these observations and their relationship, more generally, to parkinsonism, ALS and dementia are discussed.

Type
Research Article
Information
Canadian Journal of Neurological Sciences , Volume 18 , Issue S3 , August 1991 , pp. 387 - 389
Copyright
Copyright © Canadian Neurological Sciences Federation 1991

References

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