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Absence of Responses to Microstimulation at the Hand-Face Border in Baboon Primary Motor Cortex

Published online by Cambridge University Press:  18 September 2015

Donald D. Samulack ,
Robert S. Waters ,
Robert W. Dykes  and
Patricia A. McKinley
Donald D. Samulack
Affiliation:
Department of Physiology, McGill University, Montreal
Robert S. Waters*
Affiliation:
Department of Anatomy and Neurobiology, The University of Tennessee, Memphis
Robert W. Dykes
Affiliation:
Department of Physiology, McGill University, Montreal
Patricia A. McKinley
Affiliation:
Department of Physical and Occupational Therapy, McGill University, Montreal
*
Department of Anatomy and Neurobiology, The University of Tennessee, Memphis, 875 Monroe Avenue, Memphis, Tennessee, U.S.A. 38163
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Abstract:

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Intracortical microstimulation (ICMS) was used to map the primary motor cortex of four adult female baboons, anesthetized with a mixture of halothane and nitrous oxide and supplemented with sodium pentobarbital. The sequence of observed muscle contractions in response to ICMS provided evidence of an orderly mototopic representation of the tongue, face, hand, forearm and upper body. A zone of cortex unresponsive to microstimulation was consistently observed at the border between the face and hand representation of the mototopic map. This zone was observed in all four animals and was consistent over time. Repeated confirmations of the unresponsive nature of these regions were obtained both early and late in the same experiment. No motor-unit responses or muscle contractions were detected by electromyographic (EMG) recording during stimulation of the unresponsive zones. The absence of both visually observed and EMG-recorded contractions and the fact that muscle contractions could be elicited from adjacent regions of cortex with ICMS as low as 1-5 μA provide compelling evidence that the finding reflects a true physiological condition rather than an experimental artifact.

Type
Original Articles
Information
Canadian Journal of Neurological Sciences , Volume 17 , Issue 1 , February 1990 , pp. 24 - 29
Copyright
Copyright © Canadian Neurological Sciences Federation 1990

References

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