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Intravenous magnesium for acute benign headache in the emergency department: a randomized double-blind placebo-controlled trial

Published online by Cambridge University Press:  21 May 2015

Leonard R. Frank ,
Carin M. Olson ,
Klaus B. Shuler  and
Salma F. Gharib
Leonard R. Frank*
Affiliation:
Division of Emergency Medicine, University of Washington School of Medicine, Seattle, Wash
Carin M. Olson
Affiliation:
Division of Emergency Medicine, University of Washington School of Medicine, Seattle, Wash
Klaus B. Shuler
Affiliation:
University of Washington School of Medicine, Seattle, Wash
Salma F. Gharib
Affiliation:
University of Washington/Madigan Army Medical Center Affiliated Residency in Emergency Medicine, Seattle/Fort Lewis, Wash
*
Division of Emergency Medicine, Box 356123, University of Washington School of Medicine, Seattle WA 98195; 206 598-7941, [email protected]

Abstract

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Background:

Magnesium deficiency may play a role in the pathogenesis of migraines and other headaches. Studies in outpatient clinics have found that magnesium administered intravenously (IV) reduces headache pain. We investigated the effectiveness of IV magnesium in patients with acute benign headache who presented to the emergency department (ED).

Methods:

This randomized double-blind placebo-controlled trial compared 2 g of IV magnesium versus placebo for the treatment of patients with acute benign headache who presented to the EDs of two teaching hospitals. Pre- and post-treatment pain scores were measured on a 100-mm visual analog pain scale.

Results:

Forty-two patients were randomized, 21 in each treatment group. Treatment groups had similar baseline characteristics. After treatment, placebo recipients reported an 8-mm median improvement in pain, and magnesium recipients had a 3-mm improvement (p = 0.63). We found no statistically significant difference between groups for any secondary outcomes; however, the patients who received magnesium had significantly (p = 0.03) more side effects than did those in the placebo group.

Conclusions:

We found no benefit to using IV magnesium to treat patients with acute benign headache who present to the ED.

Keywords

headachemigrainemagnesiumrandomized controlled trials
Type
EM Advances • Innovations en MU
Information
Canadian Journal of Emergency Medicine , Volume 6 , Issue 5 , September 2004 , pp. 327 - 332
Copyright
Copyright © Canadian Association of Emergency Physicians 2004

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