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Clopidogrel with aspirin versus aspirin alone in prevention of stroke following transient ischemic attack or acute minor stroke

Published online by Cambridge University Press:  02 June 2015

Scott Seadon  and
Eddy Lang
Scott Seadon*
Affiliation:
Department of Emergency Medicine, University of Calgary, Calgary, AB
Eddy Lang
Affiliation:
Department of Emergency Medicine, University of Calgary, Calgary, AB
*
Correspondence to: Dr. Scott Seadon, Department of Emergency Medicine, University of Calgary, 1403 29th Street NW, Calgary, AB T2N 2T9; [email protected].

Abstract

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Clinical question

Following transient ischemic attack or acute minor stroke, does the combination of clopidogrel and aspirin reduce the risk of stroke greater than aspirin alone?

Article chosen

Wang Y, Wang Y, Zhao X, et al. Clopidogrel with aspirin in acute minor stroke or transient ischemic attack. N Engl J Med 2013;369:11-9.

Objective

The primary outcome measured in this study was ischemic or hemorrhagic stroke at 90 days of follow-up in groups assigned to treatment with a combination of aspirin and clopidogrel or aspirin alone following transient ischemic attack or acute minor stroke. The secondary outcomes were new clinical vascular events, including vascular death.

Type
Knowledge to Practice: Journal Club
Information
Canadian Journal of Emergency Medicine , Volume 17 , Issue 3 , May 2015 , pp. 315 - 317
Copyright
Copyright © Canadian Association of Emergency Physicians 2015 

References

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