Hostname: page-component-78c5997874-v9fdk Total loading time: 0 Render date: 2024-11-02T18:54:26.640Z Has data issue: false hasContentIssue false

Responses and Dialogue: Response to “Germ-Line Therapy to Cure Mitochondrial Disease: Protocol and Ethics of In Vitro Ovum Nuclear Transplantation” by Donald S. Rubenstein, David C. Thomasma, Eric A. Schon, and Michael J. Zinaman (CQ Vol 4, No 3.)

Published online by Cambridge University Press:  29 July 2009

Matthew D. Bacchetta
Affiliation:
A member of the class of 1998, Cornell University Medical College, New York.
Gerd Richter
Affiliation:
A fellow in the Center for Biomedical Ethics, University of Virginia, Department of Internal Medicine, Philipps University, Marburg, Germany.

Abstract

Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'
Type
Departments and Columns
Copyright
Copyright © Cambridge University Press 1996

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Notes

1. Rubenstein, DS, Thomasma, DC, Schon, EA, Zinaman, MJ. Germ-line therapy to cure mitochondrial disease: protocol and ethics of in vitro ovum nuclear transplantation. Cambridge Quarterly of Healthcare Ethics 1995;4:316–39.CrossRefGoogle ScholarPubMed

2. Anderson, S, Bankier, AT, Barrell, BG et al. , Sequence and organization of the human mitochondrial genome. Nature 1981;290:457–65.CrossRefGoogle ScholarPubMed

3. Wallace, DC. Report on the committee on human mitochondrial DNA. Cytogenetics and Cell Genetics 1989;51:612–21.CrossRefGoogle Scholar

4. Wallace, DC. Diseases of mitochondrial DNA. Annual Review of Biochemistry 1992;61:1174–212.CrossRefGoogle ScholarPubMed

5. Wallace, DC. Mitochondrial DNA variation in human evolution, degenerative disease, and aging. American Journal of Human Genetics 1995;57:201–23.Google ScholarPubMed

6. Wallace, DC. Mitochondrial genetics: a paradigm for aging and degenerative diseases? Science 1992;256:628–38.CrossRefGoogle ScholarPubMed

7. Walters, L. Ethical issues in human gene therapy. Journal of Clinical Ethics 1991;2:267–74.Google ScholarPubMed

8. Edwards, RG. Preconception and Preimplantation Diagnosis in Human Genetic Diseases. New York: Cambridge University Press, 1993.Google Scholar

9. Vega, MA. Gene targeting in human gene therapy. In: Vega, MA, Ed. Gene Targeting. Boca Raton, Florida: CRC Press, 1995:211–30.Google Scholar

10. Seibel, P, Trappe, J, Villani, G, Klopstock, T, Papa, S, Reichmann, H. Transfection of mitochondria: strategy towards a gene therapy of mitochondrial DNA diseases. Nucleic Acids Research 1995;23:10–7.CrossRefGoogle ScholarPubMed