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The Action of Rotenone and Tetraethyl Pyrophosphate on the isolated Heart of the Cockroach*

Published online by Cambridge University Press:  10 July 2009

B. J. Krijgsman ,
D. Dresden  and
Nelly E. Berger
B. J. Krijgsman
Affiliation:
Laboratory of Comparative Physiology, University of Utrecht.
D. Dresden
Affiliation:
Laboratory of Comparative Physiology, University of Utrecht.
Nelly E. Berger
Affiliation:
Laboratory of Comparative Physiology, University of Utrecht.
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Extract

A method based upon Yeager's technique is described permitting the study of the surviving heart of Periplaneta americana under varying conditions for several hours.

Rotenone causes diastolic contractions, decrease of frequency and cessation in diastole, threshold <0·0000005 per cent. Presumably it produces an inhibitory action on the neurogenic automatic cardiac centre.

The latent period of the rotenone action is dependent upon the concentration. Using this principle a method is developed for quantitative estimation of the activity of derris preparations.

Tetraethyl pyrophosphate has a strongly accelerating action on the frequency of the heart and increases the amplitude; in this case there is no latent period. Threshold 0·000008 per cent. Presumably TEPP activates the neurogenic heart automatism by its vigorous anticholinesterase activity.

Type
Original Articles
Information
Bulletin of Entomological Research , Volume 41 , Issue 1 , May 1950 , pp. 141 - 151
Copyright
Copyright © Cambridge University Press 1950

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