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Vitamin E kinetics in sheep

Published online by Cambridge University Press:  09 March 2007

M. Hidiroglou  and
K. Karpinski
M. Hidiroglou
Affiliation:
Animal Research Centre, Agriculture Canada, Ottawa, Ontario K1A 0C6, Canada
K. Karpinski
Affiliation:
Food Directorate, Health and Welfare Canada, Tower B, Place Vanier, Vanier, Ontario K1A 1B8, Canada
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Abstract

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1. Kinetics of physiological doses of D-α-[5-Me-3H]tocopherol(200 μCi) administered to twenty-four sheep were studied using one of four routes: intravenous, oral (capsules), intraruminal and intramuscular.

2. Blood samples were withdrawn from the jugular vein periodically for 96 h after the intravenous and oral administrations, for 168 h after the intraruminal administration and for 216 h after the intramuscular administration.

3. The study indicated that the biological availability of α-tocopherol followed the order intravenous > intramuscular > oral > intraruminal.

4. The rate of elimination was in the order intravenous > oral > intraruminal ˜ intramuscular.

5. The intravenous route was fitted with a three-compartment model, whereas the other routes exhibited a good fit for either a one- or two-compartment model.

Type
General Nutrition papers
Information
British Journal of Nutrition , Volume 58 , Issue 1 , July 1987 , pp. 113 - 125
Copyright
Copyright © The Nutrition Society 1987

References

REFERENCES

Bateman, N. E. & Vccellini, D. A. (1984). Journal of Pharmacy and Pharmacology 36, 461–464.Google Scholar
Bateman, N. E. & Vccellini, D. A. (1985). Journal of Pharmacy and Pharmacology 37, 728–729.Google Scholar
Belsley, D. A., Kuh, E. & Welsch, R. E. (1980). Regression Diagnostics. New York: Wiley.Google Scholar
Blomstrand, R. & Forsgren, L. (1968). International Journal for Vitamin and Nutrition Research 38, 328–344.Google Scholar
Csallany, A. S., Chow, C. K. & Draper, H. H. (1971). Nutrition Reports International 4, 325–333.Google Scholar
Gallo-Torres, H. E. (1970). Lipids 5, 379–384.CrossRefGoogle Scholar
Gallo-Torres, H. E. & Miller, O. N. (1971). International Journal for Vitamin and Nutrition Research 41, 339–354.Google Scholar
Gibaldi, M. & Perrier, D. (1975). Pharmacokinetics. New York: Marcel Dekker.Google Scholar
Grubbs, F. E. (1969). Technometrics 11, 1–21.Google Scholar
Hidiroglou, M. (1977). British Journal of Nutrition 37, 215–225.CrossRefGoogle Scholar
Hidiroglou, M. & Jenkins, K. J. (1974). Annales de Biologie Animale, Biochimie, Biophysique 14 (4-A), 667–677.CrossRefGoogle Scholar
Hidiroglou, M., Jenkins, K. J., Lessard, J. R. & Carson, R. B. (1970). British Journal of Nutrition 24, 917–928.Google Scholar
Hudson, D. J. (1966). Journal of the American Statistical Association 61, 1097–1129.Google Scholar
Kelleher, J. & Losowsky, M. S. (1970). British Journal of Nutrition 24, 1033–1047.CrossRefGoogle Scholar
Krishnamurthy, S. & Biery, J. G. (1963). Journal of Lipid Research 4, 330–336.Google Scholar
MacMahon, M. T., Neale, G. & Thompson, G. R. (1971). European Journal of Clinica1 Investigation 1, 288–294.Google Scholar
McMurray, C. H. & Blanchflower, W. J. (1979 a). Journal of Chromatography 178, 525–531.Google Scholar
McMurray, C. H. & Blanchflower, W. J. (1979 b). Journal of Chromatography 176, 488–492.Google Scholar
Mellors, A. & Barnes, M. McC. (1966). British Journal of Nutrition 20, 69–79.Google Scholar
Poukka, R. K. H. & Bieri, J. G. (1970). Lipids 5, 757–761.Google Scholar
Ramsey, J. C. & Anderson, M. E. (1984). Toxicology and Applied Pharmacology 73, 159–175.Google Scholar
SAS Institute (1982). SAS User's Guide. Cary, North Carolina 27511.Google Scholar
Silber, R., Winter, R. & Kayden, H. J. (1969). Journal of Clinical Investigation 48, 2989–2995.CrossRefGoogle Scholar
Sternberg, J. & Pascoe-Dawson, E. (1959). Canadian Medical Association Journal 80, 266–275.Google Scholar
Weber, F. (1983). In Digestion and Absorption of Nutrients, pp. 55–65 [Bickel, H. and Schutz, Y., editors]. Berne: Hans Huber.Google Scholar