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Vitamin E incorporated into a very-low-fat meal is absorbed from the intestine of young rats

Published online by Cambridge University Press:  09 March 2007

Elizabeth J. Brink ,
Edward Haddeman  and
Lilian B. M. Tijburg
Elizabeth J. Brink
Affiliation:
Unilever Research Laboratory, Vlaardingen, The Netherlands
Edward Haddeman
Affiliation:
Unilever Research Laboratory, Vlaardingen, The Netherlands
Lilian B. M. Tijburg
Affiliation:
Unilever Research Laboratory, Vlaardingen, The Netherlands
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Abstract

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Vegetable fats and oils are major sources of dietary vitamin E. Consequently the current trend to reduce fat consumption is accompanied by a reduction of the intake of vitamin E. In addition, the absorption of vitamin E is thought to be dependent on the hydroiysis of dietary lipids in the small intestine. It is therefore conceivable that a lower dietary fat intake also diminishes the intestinal absorption of vitamin E. The present 3-week feeding study in young male rats was designed to investigate whether different concentrations of vitamin E added to a very-low-fat product (0, 330 or 1350mg dl-α-tocopheryl acetate/kg product) were absorbed. We therefore incorporated these products into a very-low-fat meal (final fat concentration: 7 g/kg) or a low-fat meal containing 52 g fat/kg. The magnitude of vitamin E absorption from these meals was compared with that from meals containing similar amounts of vitamin E, but a high fat concentration of 190 g/kg. Apparent vitamin E absorption was defined as intake of α- tocopherol equivalents (αTE) minus faecal αTE excretion over 4 d during week 3 of the experimental period. The results of this study showed that apparent absorption of vitamin E from a very-low-fat meal varied, depending on the vitamin E concentration, from 73 to 83%. The magnitude of this vitamin E absorption was not significantly different from that from meals containing a high amount of fat. Liver vitamin E status was equal in rats fed on the very-low-fat meals compared with those fed on the high- fat meals. We conclude that, when very-low-fat or low-fat products are used as a replacement for full- fat products, addition of vitamin E to these products, as dl-α-tocopheryl acetate, might be useful in meeting the vitamin E requirements.

Keywords

Vitamin E absorptionLow-fat productsRats
Type
Dietary fat and vitamin E absorption
Information
British Journal of Nutrition , Volume 75 , Issue 6 , June 1996 , pp. 939 - 948
Copyright
Copyright © The Nutrition Society 1996

References

Bjorneboe, A., Bjorneboe, G., Bodd, E., Hagen, B. F., Kveseth, N. & Drevon, C. A. (1986). Transport and distribution of α-tocopherol in lymph, serum and liver cells in rats. Biochimica et Biophysica Acta 889, 310–315.CrossRefGoogle ScholarPubMed
Bjorneboe, A., Bjorneboe, G. & Drevon, C. A. (1990). Absorption, transport and distribution of vitamin E. Journal of Nutrition 120, 233–242.CrossRefGoogle ScholarPubMed
Blomstad, R. & Forsgren, L. (1968). Labeled tocopherols in man. International Journal of Vitamin Research 38, 328–344.Google Scholar
Burton, G. W., Ingold, K. U. & Foster, D. O. (1988). Comparison of free α-tocopherol and α-tocopheryl acetate as sources of vitamin E in rats and humans. Lipids 23, 834–840.CrossRefGoogle ScholarPubMed
Carey, M. & Small, D. (1970). The characteristics of mixed micellar solutions with particular references to bile. American Journal of Medicine 49, 590–608.CrossRefGoogle ScholarPubMed
Chow, C. K. (1985). Vitamin E and blood. World Review of Nutrition and Dietetics 45, 133–166.CrossRefGoogle ScholarPubMed
Cohn, W., Gross, P., Grun, H., Loechleiter, F., Muller, D. P. R. & Zulauf, M. (1992). Tocopherol transport and absorption. Proceedings of the Nutrition Society 51, 179–188.CrossRefGoogle ScholarPubMed
Gallo-Torres, H. (1970). Obligatory role of bile for the intestinal absorption of vitamin E. Lipids 5, 379–384.CrossRefGoogle ScholarPubMed
Hollander, D., Rim, E. & Muralidhara, K. (1975). Mechanism and site of small intestinal absorption of α-tocopherol in the rat. Gastroenterology 68, 1492–1499.CrossRefGoogle ScholarPubMed
Kayden, H. J. & Traber, M. G. (1993). Absorption, lipoprotein transport, and regulation ofplasma concentrations of vitamin E in humans. Journal of Lipid Research 34, 343–358.CrossRefGoogle Scholar
Machlin, L. J. & Gabriel, E. (1982). Kinetics of tissue α-tocopherol uptake and depletion following administration of high levels of vitamin E. Annals of the New York Academy of Sciences 393, 48–60.CrossRefGoogle ScholarPubMed
MacMahon, M. T. & Neale, G. (1970). The absorption of α-tocopherol in control subjects and in patients with intestinal malabsorption. Clinical Science 38, 197–210.CrossRefGoogle ScholarPubMed
Mann, F. C. (1920). A comparative study of the anatomy of the sphincter at the duodenal end of the common bile duct, with special reference to species of animals without a gall bladder. Anatomy Records 18, 355–360.CrossRefGoogle Scholar
Mathias, P., Harries, J., Peters, T. & Muller, D. P. R. (1981). Studies on the in vivo absorption of micellar solutions of tocopherol and tocopheryl acetate in the rat: demonstration and partial characterization of a mucosal esterase localized to the endoplasmatic reticulum of the enterocyte. Journal of Lipid Research 22, 829–837.CrossRefGoogle Scholar
Muller, D., Manning, J., Mathias, P. & Harries, J. (1976). Studies on the hydrolysis of tocopheryl esters. Internalional Journal for Vitamin and Nutrition Research 46, 207–210.Google ScholarPubMed
Muralidhara, K. & Hollander, D. (1977). Intestinal absorption of α-tocopherol inthe unanaesthetized rat. The influence of luminal constituents on the absorptive process. Journal of Laboratory and Clinical Medicine 90, 85–91.Google Scholar
Nakamura, T., Aoyama, Y., Fujita, T. & Katsui, G. (1975). Studies on tocopherol derivatives. V. Intestinal absorption of several D,1–3,43H2-α-tocopheryl esters in the rat. Lipiak 10, 627–633.Google ScholarPubMed
Remie, R., Van Dongen, J. J., Rensema, J. W. & Wunnik, G. H. J.Van (1990). General techniques. In Manual of Microsurgery on the Laboratory Rat, part 1, pp. 81–156 [Van Dongen, J. J.Remie, R.Rensema, J. W. & Wunnik, G. H. J. Van editors]. Amsterdam: Elsevier Science Publishers B.V.Google Scholar
Sokol, R. J., Heubi, J. E., Iannaccone, S., Bove, K. E., Hams, R. E. & Balistreri, W. F. (1983). The mechanism causing vitamin E deficiency during chronic childhood cholestasis. Gastroenterology 85, 1172–1182.CrossRefGoogle ScholarPubMed
Sokol, R. J., Reardon, M. C., Accurso, F. J., Stall, C., Narkewicz, M., Abman, S. H. & Hammond, K. B. (1989). Fat-soluble vitamin status during the first year of life in infants with cystic fibrosis identified by screening of newborns. American Journal of Clmical Nutrition 50, 1064–1071.Google ScholarPubMed
Stead, R. J., Muller, D. P. R., Matthews, S., Hodson, M. E. & Batten, J. C. (1986). Effect of abnormal liver function on vitamin E status and supplementation in adults with cystic fibrosis. Gut 27, 714–718.CrossRefGoogle ScholarPubMed
Traber, M. G., Cohn, W. & Muller, D. P. R. (1993). Absorption, transport and delivery to tissues. In Vitamin E in Health and Disease, pp. 35–51 [Packer, L. & Fuchs, J. editors]. New York: Marcel Dekker Inc.Google Scholar
Traber, M. G., Goldberg, I., Davidson, E., Lagmay, N. & Kayden, H. J. (1990). Vitamin E uptake by human intestinal cells during lipolysis in vitro. Gastroenterology 98, 96–103.CrossRefGoogle ScholarPubMed
Traber, M. G., Kayden, H. J., Green, J. B. & Green, M. H. (1986). Absorption of water-miscible forms of vitamin E in a patient with cholestasis and in thoracic duct canulated rats. American Journal of Clinical Nutrition 44, 914–923.CrossRefGoogle Scholar
Voorlichtingsbureau voor de Voeding (1993). Zo eet Nederland, 1992: resultaten van de Voedselconsumptiepeiling 1992. Den Haag: Voorlichtingsbureau voor de Voeding.Google Scholar