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Vitamin E and stress

7.* The interrelationships between polyunsaturated fatty acid stress, vitamin A and vitamin E in the rat and the chick

Published online by Cambridge University Press:  09 March 2007

J. Green ,
I. R. Muthy ,
A. T. Diplock ,
J. Bunyan ,
M. A. Cawthorne  and
Elspeth A. Murrell
J. Green
Affiliation:
Walton Oaks Experimenta l Station, Vitamins Ltd, Tadworth, Surrey
I. R. Muthy
Affiliation:
Walton Oaks Experimenta l Station, Vitamins Ltd, Tadworth, Surrey
A. T. Diplock
Affiliation:
Walton Oaks Experimenta l Station, Vitamins Ltd, Tadworth, Surrey
J. Bunyan
Affiliation:
Walton Oaks Experimenta l Station, Vitamins Ltd, Tadworth, Surrey
M. A. Cawthorne
Affiliation:
Walton Oaks Experimenta l Station, Vitamins Ltd, Tadworth, Surrey
Elspeth A. Murrell
Affiliation:
Walton Oaks Experimenta l Station, Vitamins Ltd, Tadworth, Surrey
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Abstract

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1. The nature of the relationship between vitamins A and E has been studied in the rat and the chick.

2. Stress induced by diets rich in polyunsaturated fatty acids (PUFA) was found to have no effect on the liver vitamin A reserves of vitamin E-deficient rats given dietary vitamin A or repeated small oral doses of vitamin A.

3. Dietary PUFA did not affect the liver vitamin A reserves of young rats given necrogenic diets deficient in vitamin E and selenium, nor were these reserves affected by the onset of liver necrosis or its prevention by Se.

4. The effect of dietary PUFA on the rate of depletion of liver vitamin A reserves in weanling rats or rats depleted initially of vitamins A and E and then given a single large dose of vitamin A was studied over periods from 2 to 12½ weeks. In three experiments the dietary PUFA did not significantly accelerate vitamin A depletion. In one experiment the depletion rate was increased, but this was not reversed by dietary vitamin E and thus could not be attributed to an enhancement of peroxidation in vivo but rather to a toxic effect. The effect of vitamin E in these experiments was not consistent but, in general, it slightly decreased the rate of depletion.

5. Large doses of vitamin A did not affect the metabolism of small amounts of [14C]D-α-tocopherol in the vitamin E-deficient rat or chick, when interaction of the two vitamins in the gastro-intestinal tract was avoided.

6. Large doses of vitamin A (40000 i.u. in total) given to vitamin E-deficient chicks receiving a diet containing 1% linoleic acid (as maize oil esters) did not accelerate the onset of encephalomalacia and therefore failed to exert a pro-oxidative effect on tissue tocopherol.

7. The conclusion drawn from these experiments was that any relationship that may exist in vivo between vitamins A and E is not concerned with an effect of vitamin E in preventing oxidation of vitamin A. A critical review of the literature on the nature of the relationship in general supports this view.

Type
Research Article
Information
British Journal of Nutrition , Volume 21 , Issue 4 , December 1967 , pp. 845 - 864
Copyright
Copyright © The Nutrition Society 1967

References

Ames, S. R., Risley, H. A. & Harris, P. L. (1954). Analyt Chem. 26, 1378.Google Scholar
Bacharach, A. L. (1940). Q. Jl Pharm. Pharmac. 13, 138.Google Scholar
Brown, R. G., Button, G. M. & Smith, J. T. (1963). J. theoret. Biol. 5, 489.Google Scholar
Brubacher, G., Schärer, K., Studer, A. & Wiss, O. (1964–1965). Z. Ernähr Wiss. 5, 190.CrossRefGoogle Scholar
Bunyan, J., Green, J., Diplock, A. T. & Robinson, D. (1967 a). Br. J. Nutr. 21, 137.CrossRefGoogle Scholar
Bunyan, J., Green, J., Diplock, A. T. & Robinson, D. (1967 b). Br. J. Nutr. 21, 147.Google Scholar
Bunyan, J., McHale, D. & Green, J. (1963). Br. J. Nutr. 17, 391.CrossRefGoogle Scholar
Bunyan, J., Murrell, E. A., Green, J. & Diplock, A. T. (1967). Br. J. Nutr. 21, 475.Google Scholar
Burgess, R. C., Gluck, M., Brisson, G. & Laughland, D. H. (1951). Archs. Biochem. Biophys. 33, 339.Google Scholar
Caldwell, K. A. & Tappel, A. L. (1964). Biochemistry, Easton 3, 1643.Google Scholar
Cawthorne, M. A., Bunyan, J., Diplock, A. T., Murrell, E. A. & Green, J. (1968). Bri. J. Nutr. 22, no. 1. (In the Press.)Google Scholar
Century, B. & Horwitt, M. K. (1965). Fedn Proc. Fedn Am. Socs exp. Biol. 24, 906.Google Scholar
Dam, H., Prange, I. & Søndergaard, E. (1952 a). Acta pharmac. tox. 8, 1.Google Scholar
Dam, H., Prange, I. & Søndergaard, E. (1952 b). Acta pharmac. tox. 8, 23.Google Scholar
Davies, A. W. & Moore, T. (1941). Nature, Lond. 147, 794.Google Scholar
Diplock, A. T., Bunyan, J., McHale, D. & Green, J. (1967). Br. J. Nutr. 21, 103.Google Scholar
Diplock, A. T., Green, J., Bunyan, J., McHale, D. & Muthy, I. R. (1967). Br. J. Nutr. 21, 115.Google Scholar
Edwin, E. E., Bunyan, J., Green, J. & Diplock, A. T. (1962). Br. J. Nutr. 16, 135.Google Scholar
Embree, N. (1947). Archs Biochem. 13, 299.Google Scholar
Golberg, L. & Smith, J. P. (1958). Br. J. exp. Path. 39, 59.Google Scholar
Green, J., Diplock, A. T., Bunyan, J., McHale, D. & Muthy, I. R. (1967). Br. J. Nutr. 21, 69.CrossRefGoogle Scholar
Green, J., Diplock, A. T., Bunyan, J., Muthy, I. R. & McHale, D. (1967). Br. J. Nutr. 21, 497.Google Scholar
Guha, A. & Roels, O. A. (1965). Biochem. biophys. Acta 111, 364.CrossRefGoogle Scholar
Harrill, I., Minarik, G. & Gifford, E. D. (1965). J. Nutr. 87, 424.Google Scholar
Hartsook, E. W., Batchelor, E. & Johnson, B. C. (1953). Proc. Soc. exp. Biol. Med. 83, 43.Google Scholar
Hebert, J. W. & Morgan, A. F. (1953). J. Nutr. 50, 175.Google Scholar
Hickman, K. C. D., Kaley, M. W. & Harris, P. L. (1944 a). J. biol. Chem. 152, 303.Google Scholar
Hickman, K. C. D., Kaley, M. W. & Harris, P. L. (1944 b). J. biol. Chem. 152, 321.Google Scholar
Horwitt, M. K., Harvey, C. C., Century, B. & Witting, L. A. (1961). J. Am. diet. Ass. 38, 231.Google Scholar
Irving, J. T. (1958). Br. J. Nutr. 12, 196.CrossRefGoogle Scholar
Lemley, J. M., Brown, R. A., Bird, O. D. & Emmett, A. D. (1947). J. Nutr. 34, 205.CrossRefGoogle Scholar
MacGee, J. (1959). Analyt. Chem. 31, 298.Google Scholar
McCarthy, P. T. & Cerecedo, L. R. (1952). J. Nutr. 46, 361.Google Scholar
Miles, M. C., Erickson, E. M. & Mattill, H. A. (1949). Proc. Soc. exp. Biol. Med. 70, 162.CrossRefGoogle Scholar
Moore, T. (1940). Biochem. J. 34, 1321.CrossRefGoogle Scholar
Moore, T. (1957). Vitamin A, p. 202. London: Elsevier.Google Scholar
Murray, T. K. & Campbell, J. A. (1955 a). J. Nutr. 57, 89.Google Scholar
Murray, T. K. & Campbell, J. A. (1955 b). J. Nutr. 57, 101.Google Scholar
Olson, R. E. (1964). Science, N. Y. 145, 926.Google Scholar
Popper, A. & Volk, B. W. (1944). Archs Path. 38, 71.Google Scholar
Prohászka, L. (1966). Br. J. Nutr. 20, 533.Google Scholar
Pudelkiewicz, W. J., Olson, G., Matterson, L. D. & Suden, J. R. (1964). J. Nutr. 83, 111.Google Scholar
Pudelkiewicz, W. J., Webster, L. & Matterson, L. D. (1964). J. Nutr. 84, 113.Google Scholar
Pudelkiewicz, W. J., Webster, L., Olson, G. & Matterson, L. D. (1964). Poult. Sci. 43, 1157.Google Scholar
Reber, E. F., Morrill, C. C., Norton, H. W. & Rhoades, H. E. (1956). J. Nutr. 58, 19.Google Scholar
Roels, O. A., Guha, A., Trout, M., Vakil, U. & Joseph, K. (1964). J. Nutr. 84, 161.CrossRefGoogle Scholar
Roels, O. A., Trout, M. & Guha, A. (1965). Biochem. J. 97, 353.CrossRefGoogle Scholar
Schwarz, K. (1962). Vitams Horm. 20, 463.CrossRefGoogle Scholar
Schwarz, K. (1965). Fedn Proc. Fedn Am. Socs exp. Biol. 24, 58.Google Scholar
Seward, C. R., Vaughan, G. & Hove, E. L. (1964). Proc. Soc. exp. Biol. Med. 117, 477.Google Scholar
Sherman, W. C. (1947). Proc. Soc. exp. Biol. Med. 65, 207.Google Scholar
Smith, H. W. (1965). J. Path. Bact. 89, 95.Google Scholar
Tappel, A. L. (1962). Vitams Horm. 20, 493.Google Scholar
Week, E. F. & Sevigne, F. J. (1949 a). J. Nutr. 39, 233.CrossRefGoogle Scholar
Week, E. F. & Sevigne, F. J. (1949 b). J. Nutr. 39, 251.Google Scholar
Witting, L. A. (1965 a). Fedn Proc. Fedn Am. Socs exp. Biol. 24, 912.Google Scholar
Witting, L. A. (1965 b). J. Am. Oil Chem. Soc. 42, 908.CrossRefGoogle Scholar
Witting, L. A., Harmon, E. M. & Horwitt, M. K. (1965). Proc. Soc. exp. Biol. Med. 120, 718.Google Scholar
Witting, L. A. & Horwitt, M. K. (1964). J. Nutr. 82, 19.Google Scholar
Wright, A. S., Crowne, R. S. & Hathway, D. E. (1965). Biochem. J. 95, 98.Google Scholar