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Vitamin B12 deficiency and the excretion of ether-soluble acids in the rat

Published online by Cambridge University Press:  09 March 2007

B. K. Armstrong
B. K. Armstrong
Affiliation:
Department of Biochemistry, Royal Perth Hospital, Perth, Western Australia
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Abstract

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1. Urinary excretion of total ether-soluble acids and of methylmalonic acid was studied in rats on vitamin B12-deficient diets with and without a vitamin B12 supplement.

2. It was shown that urinary excretion of total ether-soluble acids and methylmalonic acid was increased in vitamin B12-deficient rats and that this increase was somewhat variable between individual animals, males and females, and rats from different litters.

3. The increased excretion of these acids could readily be reversed by supplementing the diet with vitamin B12.

Type
Research Article
Information
British Journal of Nutrition , Volume 21 , Issue 2 , May 1967 , pp. 309 - 314
Copyright
Copyright © The Nutrition Society 1967

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