Hostname: page-component-78c5997874-94fs2 Total loading time: 0 Render date: 2024-11-15T03:24:35.641Z Has data issue: false hasContentIssue false
  • English
  • Français

Utilization of essential amino acids synthesized in the intestinal microbiota of monogastric mammals

Published online by Cambridge University Press:  08 March 2007

Cornelia C. Metges  and
Klaus J. Petzke
Cornelia C. Metges
Affiliation:
Research Institute for the Biology of Farm Animals (FBN), Research Unit Nutritional Physiology, Wilhelm-Stahl-Allee 2, D-18196 Dummerstorf, Germany
Klaus J. Petzke
Affiliation:
German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Stable Isotope Group Arthur-Scheunert-Allee 155, D-14558 Nuthetal, Germany, [email protected]
Rights & Permissions [Opens in a new window]

Abstract

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'
Type
Invited commentary
Information
British Journal of Nutrition , Volume 94 , Issue 5 , November 2005 , pp. 621 - 622
Copyright
Copyright © The Nutrition Society 2005

References

Backes, G, Hennig, U, Petzke, KJ, Elsner, A, Junghans, P, Nürnberg, G & Metges, CC (2002) Contribution of intestinal microbial lysine to lysine homeostasis is reduced in minipigs fed a wheat gluten-based diet. Am J Clin Nutr 76, 1317–1325.CrossRefGoogle ScholarPubMed
Belenguer, Á, Balcells, J, Guada, JA, Decoux, M & Milne, E (2005) Protein recycling in growing rabbits: contribution of microbial lysine to amino acid metabolism. Br J Nutr 93, 000–000.Google Scholar
Fuller, MF & Reeds, PJ (1998) Nitrogen recycling in the gut. Annu Rev Nutr 18, 385–411.CrossRefGoogle ScholarPubMed
Metges, CC (2000) Contribution of microbial amino acid homeostasis of the host. J Nutr 130, Suppl., 1857S–1864S.CrossRefGoogle ScholarPubMed
Metges, CC & Loh, G (2003) Intestinal microbial amino acid synthesis and its importance for the amino acid homeostasis of the monogastric host. In Progress in Research on Energy and Protein Metabolism, EAAP Publication no. 109, pp. 579–592 [Souffrant, WB and Metges, CC, editors]. Wageningen: Academic Publishers.Google Scholar
Metges, CC & Petzke, KJ (1997) Measurement of 15 N/ 14 N isotopic composition in individual plasma free amino acids of human adults at natural abundance by gas chromatography–combustion isotope ratio mass spectrometry. Anal Biochem 247, 158–164.CrossRefGoogle Scholar
Metges, CC, Petzke, KJ & Hennig, U (1996) Gas chromatography/combustion/isotope ratio mass spectrometric comparison of N -acetyl- and N -pivaloyl amino acid esters to measure 15 N isotopic abundances in physiological samples: a pilot study on amino acid synthesis in the upper gastrointestinal tract of minipigs. J Mass Spectrom 31, 367–376.3.0.CO;2-V>CrossRefGoogle Scholar
Metges, CC, El-Khoury, AE, Henneman, L, Petzke, KJ, Grant, I, Bedri, S, Pereira, PP, Ajami, AM, Fuller, MF & Young, VR (1999) Availability of intestinal microbial lysine to lysine homeostasis in human subjects. Am J Physiol 277, E597–E607.Google ScholarPubMed
Metges, CC, Petzke, KJ, El-Khoury, AE, Henneman, L, Grant, I, Bedri, S, Regan, MM, Fuller, MF & Young, VR (1999) Incorporation of urea and ammonia nitrogen into ileal and fecal microbial proteins and plasma free amino acids in normal men and ileostomates. Am J Clin Nutr 70, 1046–1058.CrossRefGoogle ScholarPubMed
Millward, DJ, Forrester, T, Ah-Sing, E, Yeboah, N, Gibson, N, Badaloo, A, Boyne, M, Reade, M & Jackson, AA (2000) The transfer of 15 N from urea to lysine in the human infant. Br J Nutr 83, 505–512.CrossRefGoogle ScholarPubMed
Torrallardona, D, Harris, CI, Coates, ME & Fuller, MF (1996 a) Microbial amino acid synthesis and utilization in rats: incorporation of 15 N from 15 NH 4 Cl into lysine in the tissues of germ-free and conventional rats. Br J Nutr 76, 689–700.CrossRefGoogle Scholar
Torrallardona, D, Harris, CI & Fuller, MF (1996 b) Microbial amino acid synthesis and utilization in rats: the role of coprophagy. Br J Nutr 76, 701–709.CrossRefGoogle ScholarPubMed
Torrallardona, D, Harris, CI & Fuller, MF (2003 a) Lysine synthesized by the gastrointestinal microflora of pigs is absorbed, mostly in the small intestine. Am J Physiol Endocrinol Metab 284, E1177–E1180.CrossRefGoogle ScholarPubMed
Torrallardona, D, Harris, CI & Fuller, MF (2003 b) Pigs’ gastrointestinal microflora provide them with essential amino acids. J Nutr 133, 1127–1131.CrossRefGoogle ScholarPubMed
Van der Schoor, SR, Van Goudoever, JB, Stoll, B, Henry, JF, Rosenberger, JR, Burrin, DG & Reeds, PJ (2001) The pattern of intestinal substrate oxidation is altered by protein restriction in pigs. Gastroenterology 121, 1167–1175.CrossRefGoogle ScholarPubMed
Van Goudoever, JB, Stoll, B, Henry, JF, Burrin, DG & Reeds, PJ (2000) Adaptive regulation of intestinal lysine metabolism. Proc Natl Acad Sci USA 97, 11620–11625.CrossRefGoogle ScholarPubMed