Hostname: page-component-586b7cd67f-l7hp2 Total loading time: 0 Render date: 2024-11-27T13:33:37.172Z Has data issue: false hasContentIssue false
  • English
  • Français

Tissue lipids in calves suffering from muscular dystrophy

Published online by Cambridge University Press:  09 March 2007

Ritva Poukka
Ritva Poukka
Affiliation:
Department of Biochemistry, College of Veterinary Medicine, Helsinki, Finland
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. Lipids of the heart muscle, skeletal muscle and liver were investigated in healthy calves and in calves suffering from enzootic muscular dystrophy with special regard to the fatty acid composition of the phospholipids and triglycerides. 2. Healthy young calves and older calves differed in the fatty acid composition of these tissues. The tissue phospholipids of healthy young calves contained less linoleic acid and more monounsaturated fatty acids than those of older calves. Of the saturated fatty acids, palmitic acid content tended to be higher in young calves and stearic acid content tended to be higher in older calves. 3. The stearic acid content of tissue triglycerides was lower in young calves than in older calves. 4. Fatty aldehydes were present in the phospholipid fraction of the heart muscle and of the skeletal muscle. Stearaldehyde content was higher in older calves than in young calves. 5. In calves with muscular dystrophy definite changes in the fatty acid composition of the phospholipids were found. In young calves the content of linoleic acid was higher and that of monounsaturated fatty acids lower in tissues of diseased animals than in the corresponding tissues of healthy controls. Both in young and older calves arachidonic acid content was higher in the degenerated areas of the skeletal muscle than in the healthy controls. 6. Possible relationships between the tocopherol and arachidonic acid contents of the tissues are discussed. 7. In the triglyceride fraction the differences between diseased and healthy tissues were less significant than in the phospholipid fraction in young calves. In older calves no significant differences were found. 8. An increase in lipid content was found in the degenerated areas of the skeletal muscle and a decrease in livers from diseased animals. An increase in free cholesterol was found in the degenerated areas of the skeletal muscle. The triglyceride content of livers from diseased animals was decreased. The relative proportion of phospholipids was less in skeletal muscle and higher in liver of diseased animals than in the corresponding tissues of healthy controls.

Type
Research Article
Information
British Journal of Nutrition , Volume 20 , Issue 2 , May 1966 , pp. 245 - 256
Copyright
Copyright © The Nutrition Society 1966

References

REFERENCES

Abell, L. L., Levy, B. B., Brodie, B. B. & Kendall, F. E. (1952). J. biol. Chem. 195, 357.CrossRefGoogle Scholar
Adams, R. S., Gullickson, T. W., Gander, J. E. & Sautter, J. H. (1959). J. Dairy Sci. 42, 1552.CrossRefGoogle Scholar
Adams, R. S., Gullickson, T. W., Sautter, H. J. & Gander, J. E. (1954). J. Dairy Sci. 37, 655.Google Scholar
Adams, R. S., Sautter, J. H., Gullickson, T. W. & Gander, J. E. (1959). J. Dairy Sci. 42, 1580.Google Scholar
Andersson, P. (1960). Acta path. microbiol. scand. 48, Suppl.134, p. 1.Google Scholar
Barker, H. B., Wise, G. H. & Jacobson, N. L. (1952). J. Dairy Sci. 35, 507.CrossRefGoogle Scholar
Bartlett, G. R. (1959). J. biol. Chem. 234, 466.CrossRefGoogle Scholar
Bernhard, K., Leisinger, S. & Pedersen, W. (1963). Helv. chim. Acta, 46, 1767.CrossRefGoogle Scholar
Bieri, J. G. (1964). Fedn Proc. Fedn Am. Socs exp. Biol. 23, 394.Google Scholar
Bieri, J. G., Dam, H., Prange, I. & Søndergaard, E. (1961). Acta physiol. scand. 52, 36.CrossRefGoogle Scholar
Blaxter, K. L., Brown, F., Wood, W. A. & MacDonald, A. M. (1953). Br. J. Nutr. 7, 337.CrossRefGoogle Scholar
Blaxter, K. L. & McGill, R. F. (1955). Vet. Revs Annot. 1, 91.Google Scholar
Blaxter, K. L., Watts, P. S. & Wood, W. A. (1952). Br. J. Nutr. 6, 125.CrossRefGoogle Scholar
Blaxter, K. L. & Wood, W. A. (1952). Br. J. Nutr. 6, 144.CrossRefGoogle Scholar
Farquhar, J. W. (1962). J. Lipid Res. 3, 21.Google Scholar
Farquhar, J. W., Insull, W. Jr, Rosen, P., Stoffel, W. & Ahrens, E. H. Jr. (1959). Nutr. Rev. 17, Suppl. p.1Google Scholar
Folch, J., Lees, M. & Stanley, G. H. S. (1957). J. biol. Chem. 226, 497.CrossRefGoogle Scholar
Garton, G. A., Duncan, W. R. H., Blaxter, K. L., McGill, R. F., Sharman, G. A. M. & Hutcheson, M. K. (1956). Nature, Lond., 177, 792.CrossRefGoogle Scholar
Hamilton, J. W. & Tappel, A. L. (1963). J. Nutr. 79, 493.CrossRefGoogle Scholar
Hilditch, T. P. & Williams, P. N. (1964). The Chemical Constitution of Natural Fats, 4th ed. London: Chapman and Hall Ltd.Google Scholar
Horwitt, M. K. (1965). Fedn Proc. Fedn Am. Socs exp. Biol. 24, 68.Google Scholar
Machlin, L. J. (1962). In Lipids and their Oxidation. Chapter 14. [Schultz, H. W., editor.] Westport, Conn: Avi Publishing Co.Google Scholar
Mead, J. F. & Gouze, M. L. (1961). Proc. Soc. exp. Biol. Med. 106, 4.Google Scholar
Oksanen, H. E. (1965). Acta vet. scand. 6, Suppl.2.Google Scholar
Poukka, R., Vasenius, L. & Turpeinen, O. (1962). J. Lipid Res. 3, 128.CrossRefGoogle Scholar
Shorland, F. B., Weenink, R. O., Johns, A. T. & McDonald, I. R. C. (1957). Biochem. J. 67, 328.CrossRefGoogle Scholar
Slagsvold, L. & Lund-Larsen, H. (1934). Norsk VeetTidsskr. 46, 529.Google Scholar
Stoffel, W., Chu, F. & Ahrens, E. H. (1959). Analyt. Chem. 31, 307.CrossRefGoogle Scholar
Witting, L. A. & Honvitt, M. K. (1964). J. Nutr. 82, 19.CrossRefGoogle Scholar
Woodford, F. P. & van Gent, C. M. (1959–1960). J. Lipid Res. 1, 188.Google Scholar