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Supplementation of a restricted maternal diet with protein or carbohydrate alone prevents a reduction in fetal muscle fibre number in the guinea-pig

Published online by Cambridge University Press:  09 March 2007

Catherine M. Dwyer  and
Neil C. Stickland
Catherine M. Dwyer
Affiliation:
Department of Veterinary Basic Sciences, The Royal Veterinary College, Royal College Street, LondonNWI OTU
Neil C. Stickland
Affiliation:
Department of Veterinary Basic Sciences, The Royal Veterinary College, Royal College Street, LondonNWI OTU
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Abstract

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A 60 % reduction in maternal feed intake is known to cause a reduction of approximately 20 % in biceps brachii fibre number in the guinea-pig fetus. This investigation was designed to isolate the dietary component responsible by reducing all dietary components to 60 % of the ad lib. level and supplementing the protein, carbohydrate or fat component to the level of the ad lib. intake. Fetal muscles were examined at 50 d gestation to determine numbers of primary and secondary fibres, and at term to determine total fibre number. Fetal and neonatal weights were reduced in all restricted groups (P < 0.05) when compared with ad lib. controls. At term this reduction was significantly less (P < 0.05) in the protein-supplemented group (20%) than in the 60 %-restricted and fat-supplemented groups (43%) and the carbohydrate-supplemented group (34%). Biceps brachii fibre numbers were reduced in the 60%-restricted and fat-supplemented groups by 14–16%, but fibre numbers were similar in control, protein-supplemented and carbohydrate-supplemented groups. Any reduction in fibre number was in the secondary fibre component of total fibre number. Therefore, biceps brachii fibre numbers were reduced only when maternal diets were deficient in both protein and carbohydrate.

Keywords

ProteinCarbohydrateMalnutritionFetal myofibre developmentGuinea-pig
Type
Effects of maternal diet on the development of fetal muscle
Information
British Journal of Nutrition , Volume 72 , Issue 2 , August 1994 , pp. 173 - 180
Copyright
Copyright © The Nutrition Society 1994

References

REFERENCES

Anugwa, F.O.I. & Pond, W.G. (1989). Reproduction and organ weights in rats fed high protein, restricted balanced diets or restricted nonprotein calories. Nutrition Reports International 40, 879–892.Google Scholar
Atinmo, T., Baldijao, C., Pond, W. G. & Barnes, R. H. (1976). Maternal protein malnutrition during gestation alone and its effects on plasma insulin levels of the pregnant pig, its fetuses and the developing offspring. Journal of Nutrition 106, 1647–1653.CrossRefGoogle ScholarPubMed
Battaglia, F. C. & Meschia, G. (1978). Principle substrates of fetal metabolism. Physiological Reviews 58, 499–527.CrossRefGoogle Scholar
Bossi, E. & Greenberg, R.E. (1972). Sources of blood glucose in the rat fetus. Pediatric Research 6, 765–772.CrossRefGoogle ScholarPubMed
Cheek, D. B. & Hill, D. E. (1970). Muscle and liver cell growth: role of hormones and nutritional factors. Federation Proceedings 29, 1503–1509.Google ScholarPubMed
Dardevet, D., Manini, M., Balage, M., Sornet, C. & Grizard, J. (1991). Influence of low- and high-protein diets on insulin and IGF-I binding to skeletal muscle and liver in the growing rat. British Journal of Nutrition 65, 47–60.CrossRefGoogle ScholarPubMed
Dwyer, C. M., Madgwick, A. J. A., Ward, S. S. & Stickland, N.C. (1993). The effect of maternal undernutrition, imposed before or after the first trimester, on muscle fibre development in the guinea pig. Journal of Anatomy 183, 200 Abstr.Google Scholar
Dwyer, C. M. & Stickland, N. C. (1992). Does the anatomical location of a muscle affect the influence of undernutrition on muscle fibre number? Journal of Anatomy 181, 373–376.Google ScholarPubMed
Faulkener, A. & Jones, C. T. (1976). Metabolic concentrations in the liver of the adult and developing guinea pig and the control of glycolysis in vivo. Archives of Biochemistry and Biophysics 176, 171–180.CrossRefGoogle Scholar
Gresham, E. L., James, E. J., Raye, J. R., Battagha, F. C., Makowski, E. L. & Meschia, G. (1972). Production and excretion of urea by the foetal lamb. Pediatric Research 50, 372–379.Google Scholar
Guth, L. & Samaha, F. J. (1970). Research note: procedure for the histochemical demonstration of actomyosin ATPase. Experimental Neurology 28, 365–367.CrossRefGoogle Scholar
Handel, S. E. & Stickland, N. C. (1987). Muscle cellularity and birth weight. Animal Production 44, 311–317.Google Scholar
Jepson, M. M., Bates, P. C. & Millward, D. J. (1988). The role of insulin and thyroid hormones in the regulation of muscle growth and protein turnover in response to dietary protein in the rat. British Journal of Nutrition 59, 397–415.Google ScholarPubMed
Jones, C. T. (1982). Comparative aspects of hepatic glucose metabolism during foetal development. Biochemical Society Transactions 9, 375–376.CrossRefGoogle Scholar
Jones, C. T. & Ashton, I. R. (1976). The appearance, properties and functions of gluconeogenic enzymes in the liver and kidney of the guinea pig during foetal and early neonatal development. Archives of Biochemistry and Biophysics 174, 506–522.CrossRefGoogle ScholarPubMed
Jones, C. T. & Rolph, T. P. (1985). Metabolism during foetal life: a functional assessment of metabolic development. Physiological Reviews 65, 357430.CrossRefGoogle ScholarPubMed
Moats-Staats, B. M., Brady, J. L., Underwood, L. E. & DErcole, A. J. (1989). Dietary protein restriction in artificially reared neonatal rats causes a reduction in IGF-1 gene expression. Endocrinology 125, 2368–2375.CrossRefGoogle Scholar
Pilistine, S. J., Moses, A. C. & Munro, H. N. (1984). Placental lactogen administration reverses the effect of a low protein diet on maternal and foetal serum somatomedin levels in the pregnant rat. Proceedings of the National Academy of Sciences USA 81, 5853–5857.CrossRefGoogle ScholarPubMed
Pond, W. G. (1973). Influence of maternal protein and energy nutrition during gestation on progeny performance in swine. Journal of Animal Science 36, 175–182.CrossRefGoogle ScholarPubMed
Pond, W. G., Maurer, R. R. & Klindt, J. (1991). Fetal organ response to maternal protein deprivation during pregnancy in swine. Journal of Nutrition 121, 504–509.CrossRefGoogle ScholarPubMed
Pond, W. G., Strachan, D. N., Sinha, Y. N., Walker, E. F., Dunn, J. A. & Barnes, R. H. (1969). Effect of protein deprivation of swine during all or part of gestation on birth weight, postnatal growth rate and nucleic acid content of brain and muscle of progeny. Journal of Nutrition 99, 61–67.CrossRefGoogle ScholarPubMed
Pond, W. G., Wagner, W. C., Dunn, J. A. & Walker, E. F. (1968). Reproduction and early post natal growth of progeny in swine fed a protein-free diet during gestation. Journal of Nutrition 94, 309–316.CrossRefGoogle Scholar
Pond, W. G. & Wu, J. F. (1981). Mature body size and life span of male and female progeny of primiparous rats fed a low protein or adequate diet throughout pregnancy. Journal of Nutrition 111, 1949–1954.CrossRefGoogle ScholarPubMed
Pond, W. G., Yen, J.-T. & Mersmann, H. J. (1987). Effect of severe dietary protein, non-protein calories or feed restriction during gestation on postnatal growth of progeny in swine. Growth 51, 355–371.Google ScholarPubMed
Pond, W. G., Yen, J.-T., Mersmann, H. J. & Maurer, R. R. (1990). Reduced mature size in progeny of swine severely restricted in protein intake during pregnancy. Growth, Development and Aging 54, 77–84.Google ScholarPubMed
Soliman, A. T., Hassan Abd. el Hadi, I., Aref, M. K., Hintz, R. L., Rosenfeld, F. G. & Rogol, A. D. (1986). Serum IGF-I and IGF-I1 concentrations and growth hormone and insulin responses to arginine infusion in children with protein-energy malnutrition before and after nutritional rehabilitation. Pediatric Research 20, 1122–1130.CrossRefGoogle ScholarPubMed
Sutherland, S. D. & Festing, M. F. W. (1986). The guinea pig. In The UFAW Handbook on the Care and Management of Laboratory Animals, pp. 393410 [Poole, T. B., editor]. London: Longman Scientific & Technical.Google Scholar
Vandehaar, M. J., Moats-Staats, B. M., Davenport, M. L., Walker, J. L., Ketelslegers, J.-M., Sharma, B. K. & Underwood, L. E. (1991). Reduced serum concentrations of IGF-I in protein-restricted growing rats are accompanied by reduced IGF-1 mRNA levels in liver and skeletal muscles. Journal of Endocrinology 130, 305–312.CrossRefGoogle Scholar
Ward, S. S. & Stickland, N. C. (1991). Why are fast and slow muscles differentially affected during prenatal undernutrition? Muscle and Nerve 14, 259–267.CrossRefGoogle ScholarPubMed
Wimick, M. (1970). Nutrition and nerve cell growth. Federation Proceedings 29, 1510–1515.Google Scholar
Yahya, Z. A. H., Bates, P. C. & Millward, D. J. (1990). Responses to protein deficiency of plasma and tissue IGF-1 levels and proteoglycan synThesis rates in rat skeletal muscle and bone. Journal of Endocrinology 127, 497–503.CrossRefGoogle ScholarPubMed
Young, V. R. & Alexis, S. D. (1968). In vitro activity of ribosomes and RNA content of skeletal muscle in young rats fed adequate or low protein. Journal of Nutrition 96, 255–262.CrossRefGoogle ScholarPubMed
Zeman, F. J. & Stanbrough, E. C. (1969). Effect of maternal protein deficiency on cellular development in the foetal rat. Journal of Nutrition 99, 274–282.CrossRefGoogle Scholar