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Studies on platelet 5-hydroxytryptamine in East Africans

Published online by Cambridge University Press:  09 March 2007

M. A. Crawford ,
I. L. Hansen  and
K. Somers
M. A. Crawford
Affiliation:
Nuffield Institute of Comparative Medicine, The Zoological Society of London, Regent's Park, London, NW 1
I. L. Hansen
Affiliation:
Departments of Medicine and Biochemistry, Makerere University College, Kampala, Uganda
K. Somers
Affiliation:
Departments of Medicine and Biochemistry, Makerere University College, Kampala, Uganda
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Abstract

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1. A study was done on the platelet 5-hydroxytryptamine (5HT) from Africans in areas where endomyocardial fibrosis is common.

2. There were only small differences between the mean platelet or blood 5HT in Europeans and plantain-eating Africans; the distribution of the results showed a wider scatter in the African community, including values outside the upper limits of normal but not within the range reported for carcinoid.

3. Patients in hospital had lower platelet 5HT contents regardless of cardiac condition or disease than healthy Africans on similar diets, suggesting no specific abnormality related to platelet 5HT levels and endomyocardial fibrosis.

4. A small number of radioactive studies suggested that only 1–4 % of oral 5HT may reach the platelets; a significant increase in platelet 5HT did occur after a plantain meal; the in-crease after a meal but not after oral 5HT may be explained by release of endogenous 5HT from the small intestine under the influence of the high bulk of the diet. Attention is drawn to the high incidence of adult intussusception and volvulus associated with such diets.

Type
Research Article
Information
British Journal of Nutrition , Volume 24 , Issue 2 , June 1970 , pp. 385 - 392
Copyright
Copyright © The Nutrition Society 1970

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