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Strategies for cancer prevention: the role of diet

Published online by Cambridge University Press:  09 March 2007

J. A. Milner
J. A. Milner*
Affiliation:
Nutrition Department, The Pennsylvania State University and Nutritional Science Research Group, Division of Cancer Prevention, National Cancer Institute, 6116 Executive Boulevard Suite 703, Rockville, MD 20892, USA
*
Corresponding author: Dr J. A. Milner, tel +1 301 496 0118, fax +1 301 480 3925, email [email protected]
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Abstract

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Linkages between diet habits and cancer risk have surfaced from a multitude of epidemiological and preclinical studies. Collectively these studies provide rather compelling evidence that dietary components modify the incidence and biological behavior of tumors. While the risk of breast, prostate, colon, lung and liver cancers are frequently associated with dietary patterns, inconsistencies are not uncommon. These inconsistencies likely reflect the multi-factorial and complex nature of cancer and the specificity that individual dietary constituents have in modifying cancer related genetic pathways. The complexity of defining the role of diet is underscored by the numerous and diverse essential and non-essential components that may alter one or more phases of the cancer process. The explosive increase in the recognition of genes and pathways for regulating cell growth and development, and evaluating the response to hormones and other chemicals synthesized by the body, offers exciting opportunities for unraveling the molecular targets by which dietary components influence cancer prevention. It is recognized that all cells have unique ‘signatures’ that are characterized by active and inactive genes and cellular products. It is certainly plausible that bridging knowledge about these unique cellular characteristics with the molecular targets for nutrients can be used to assist in optimizing nutrition and minimizing cancer risk.

Keywords

DietCancerPolymorphismGenesPhytochemicals
Type
Research Article
Information
British Journal of Nutrition , Volume 87 , Issue S2 , May 2002 , pp. S265 - S272
Copyright
Copyright © The Nutrition Society 2002

References

Abdulla, M & Gruber, P (2000) Role of diet modification in cancer prevention. Biofactors 12, 45–51.CrossRefGoogle ScholarPubMed
Ahuja, N & Issa, JP (2000) Aging, methylation and cancer. Histology and Histopathology 15, 835–842.Google ScholarPubMed
Asami, S, Hirano, T, Yamaguchi, R, Tsurudome, Y, Itoh, H & Kasai, H (2000) Increase in 8-hydroxyguanine and its repair activity in the esophagi of rats given long-term ethanol and nutrition-deficient diet. Japanese Journal of Cancer Research 91, 973–978.CrossRefGoogle ScholarPubMed
Awad, AB & Fink, CS (2000) Phytosterols as anticancer dietary components: evidence and mechanism of action. Journal of Nutrition 130, 2127–2130.CrossRefGoogle ScholarPubMed
Baron, JA (2001) Intermediate effect markers for colorectal cancer. IARC Scientific Publications 154, 113–129.Google ScholarPubMed
Basak, R, Bhattacharya, R & Chatterjee, M (2001) 1-alpha,25-dihydroxyvitamin D(3) inhibits rat liver ultrastructural changes in diethylnitrosamine-initiated and phenobarbital promoted rat hepatocarcinogenesis. Journal of Cellular Biochemistry 81, 357–367.3.0.CO;2-Q>CrossRefGoogle Scholar
Bradlow, HL, Telang, NT, Sepkovic, DW & Osborne, MP (1999) Phytochemicals as modulators of cancer risk. Advances in Experimental Medicine and Biology 472, 207–221.CrossRefGoogle ScholarPubMed
Brown, L, Rosner, B, Willett, WW & Sacks, FM (1999) Cholesterol-lowering effects of dietary fiber: a meta-analysis. American Journal of Clinical Nutrition 69, 30–42.CrossRefGoogle ScholarPubMed
Chapkin, RS, Fan, Y & Lupton, JR (2000) Effect of diet on colonic-programmed cell death: molecular mechanism of action. Toxicology Letters 112–113, 411–414.CrossRefGoogle ScholarPubMed
Chen, J, Giovannucci, EL & Hunter, DJ (1999) MTHFR polymorphism, methyl-replete diets and the risk of colorectal carcinoma and adenoma among U.S. men and women: an example of gene-environment interactions in colorectal tumorigenesis. Journal of Nutrition 129, 560S–564S.CrossRefGoogle ScholarPubMed
Choi, SW & Mason, JB (2000) Folate and carcinogenesis: an integrated scheme. Journal of Nutrition 130, 129–132.CrossRefGoogle ScholarPubMed
Clark, LC, Combs, GF Jr, Turnbull, BW, Slate, EH, Chalker, DK, Chow, J, Davis, LS, Glover, RA, Graham, GF, Gross, EG, Krongrad, A, Lesher, JL Jr, Park, HK, Sanders, BB Jr, Smith, CL & Taylor, JR (1996) Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial. Nutritional Prevention of Cancer Study Group. Journal American Medical Association 276, 1957–1963.CrossRefGoogle ScholarPubMed
Cotton, SC, Sharp, L, Little, J & Brockton, N (2000) Glutathione S-transferase polymorphisms and colorectal cancer: a HuGE review. American Journal of Epidemiology 151, 7–32.CrossRefGoogle ScholarPubMed
Craig, WJ (1997) Phytochemicals: guardians of our health. Journal of the American Dietetic Association 97, S199–S204.CrossRefGoogle ScholarPubMed
Cravo, M, Fidalgo, P, Pereira, AD, Gouveia-Oliveira, A, Chaves, P, Selhub, J, Mason, JB, Mira, FC & Leitao, CN (1994) DNA methylation as an intermediate biomarker in colorectal cancer: modulation by folic acid supplementation. European Journal of Cancer Prevention 3, 473–479.CrossRefGoogle ScholarPubMed
Davis, CD, Uthus, EO & Finley, JW (2000) Dietary selenium and arsenic affect DNA methylation in vitro in Caco-2 cells and in vivo in rat liver and colon. Journal of Nutrition 130, 2903–2909.CrossRefGoogle ScholarPubMed
Diplock, AT, Charleux, JL, Crozier-Willi, G, Kok, FJ, Rice-Evans, C, Roberfroid, M, Stahl, W & Vina-Ribes, J (1998) Functional food science and defence against reactive oxidative species. British Journal of Nutrition 80, S77–S112.CrossRefGoogle ScholarPubMed
Duthie, SJ (1999) Folic acid deficiency and cancer: mechanisms of DNA instability. British Medical Bulletin 55, 78–92.CrossRefGoogle ScholarPubMed
Duthie, SJ, Narayanan, S, Blum, S, Pirie, L & Brand, GM (2000) Folate deficiency in vitro induces uracil misincorporation and DNA hypomethylation and inhibits DNA excision repair in immortalized normal human colon epithelial cells. Nutrition and Cancer 37, 45–51.CrossRefGoogle ScholarPubMed
Fang, JY, Xiao, SD, Zhu, SS, Yuan, JM, Qiu, DK & Jiang, SJ (1997) Relationship of plasma folic acid and status of DNA methylation in human gastric cancer. Journal of Gastroenterology 32, 171–175.CrossRefGoogle ScholarPubMed
Ganther, HE (1999) Selenium metabolism, selenoproteins and mechanisms of cancer prevention: complexities with thioredoxin reductase [review]. Carcinogenesis 20, 1657–1666.CrossRefGoogle ScholarPubMed
Gill, HS & Cross, ML (2000) Anticancer properties of bovine milk. British Journal of Nutrition 84 (Suppl 1), 161–166.CrossRefGoogle ScholarPubMed
Gray, T, Koo, J & Nettesheim, P (2001) Regulation of mucous differentiation and mucin gene expression in the tracheobronchial epithelium. Toxicology 160, 35–46.CrossRefGoogle ScholarPubMed
Greenwald, P, Clifford, CK & Milner, JA (2001) Diet and cancer prevention. European Journal of Cancer 37, 948–965.CrossRefGoogle ScholarPubMed
Guarente, L & Kenyon, C (2000) Genetic pathways that regulate ageing in model organisms. Nature 408, 255–262.CrossRefGoogle ScholarPubMed
Guidance for Industry (1999) Significant Scientific Agreement in the Review of Health Claims for Conventional Foods and Dietary Supplements. Fed Reg 64 245, 71794.Google Scholar
Habuchi, T, Suzuki, T, Sasaki, R, Wang, L, Sato, K, Satoh, S, Akao, T, Tsuchiya, N, Shimoda, N, Wada, Y, Koizumi, A, Chihara, J, Ogawa, O & Kato, T (2000) Association of vitamin D receptor gene polymorphism with prostate cancer and benign prostatic hyperplasia in a Japanese population. Cancer Research 60, 305–308.Google Scholar
Ingles, SA, Garcia, DG, Wang, W, Nieters, A, Henderson, BE, Kolonel, LN, Haile, RW & Coetzee, GA (2000) Vitamin D receptor genotype and breast cancer in Latinas (United States). Cancer Causes Control 11, 25–30.CrossRefGoogle ScholarPubMed
Ip, C, Thompson, HJ & Ganther, HE (2000) Selenium modulation of cell proliferation and cell cycle biomarkers in normal and premalignant cells of the rat mammary gland. Cancer Epidemiology Biomarkers and Prevention 9, 49–54.Google ScholarPubMed
Jiang, C, Jiang, W, Ip, C, Ganther, H & Lu, J (1999) Selenium-induced inhibition of angiogenesis in mammary cancer at chemopreventive levels of intake. Molecular Carcinogenesis 26, 213–225.3.0.CO;2-Z>CrossRefGoogle ScholarPubMed
Kensler, TW, Curphey, TJ, Maxiutenko, Y & Roebuck, BD (2000) Chemoprotection by organosulfur inducers of phase 2 enzymes: dithiolethiones and dithiins. Drug Metabolism and Drug Interactions 17, 3–22.CrossRefGoogle ScholarPubMed
Kim, YI, Pogribny, IP, Basnakian, AG, Miller, JW, Selhub, J, James, SJ & Mason, JB (1997) Folate deficiency in rats induces DNA strand breaks and hypomethylation within the p53 tumor suppressor gene. American Journal of Clinical Nutrition 65, 46–52.CrossRefGoogle ScholarPubMed
Knowles, LM & Milner, JA (2000) Allyl sulfides modify cell growth. Drug Metabolism Drug Interactions 17, 81–107.CrossRefGoogle ScholarPubMed
Kritchevsky, D (1999) Caloric restriction and experimental carcinogenesis. Toxicological Sciences 52 (2 Suppl), 13–16.CrossRefGoogle ScholarPubMed
Kruse, HP, Kleessen, B & Blaut, M (1999) Effects of inulin on faecal bifidobacteria in human subjects. British Journal of Nutrition Nov 82, 375–382.CrossRefGoogle ScholarPubMed
Lipkin, M, Reddy, B, Newmark, H & Lamprecht, SA (1999) Dietary factors in human colorectal cancer. Annual Review of Nutrition 19, 545–586.CrossRefGoogle ScholarPubMed
Liu, JZ & Milner, JA (1992) Age, dietary selenium and quantity of 7,12-dimethylbenz(a)anthracene influence the in vivo occurrence of rat mammary DNA adducts. Journal of Nutrition 122, 1361–1368.CrossRefGoogle ScholarPubMed
Ma, J, Stampfer, MJ, Giovannucci, E, Artigas, C, Hunter, DJ, Fuchs, C, Willett, WC, Selhub, J, Hennekens, CH & Rozen, R (1997) Methylenetetrahydrofolate reductase polymorphism, dietary interactions, and risk of colorectal cancer. Cancer Research 57, 1098–1102.Google ScholarPubMed
Martinez, ME & Giovannucci, E (1997) Diet and the prevention of cancer. Cancer Metastasis Review 16, 357–376.CrossRefGoogle ScholarPubMed
Mason, JB & Levesque, T (1996) Folate: effects on carcinogenesis and the potential for cancer chemoprevention. Oncology 10, 1727–1744.Google ScholarPubMed
Milner, JA (2000 a) Nonnutritive components in foods as modifiers of the cancer process. In Preventive Nutrition, pp. 135–152. Totowa, NJ: The Humana Press.Google Scholar
Milner, JA (2000 b) Functional foods: the US perspective. American Journal of Clinical Nutrition 71 (6 Suppl), 1654S–1659S.CrossRefGoogle ScholarPubMed
Nakamura, Y, Tomokane, I, Mori, T, Tanaka, A, Koutani, J, Matsuo, T, Okamoto, S, Sato, K & Ohtsuki, K (2000) DNA repair effect of traditional sweet pepper Fushimi-togarashi: seen in suppression of UV-induced cyclobutane pyrimidine dimer in human fibroblast. Bioscience Biotechnology Biochemistry 64, 2575–2580.CrossRefGoogle ScholarPubMed
Paabo, S (2001) Genomics and society. The human genome and our view of ourselves. Science 291, 1219–1220.CrossRefGoogle Scholar
Pierre, F, Perrin, P, Champ, M, Bornet, F, Meflah, K & Menanteau, J (1997) Short-chain fructo-oligosaccharides reduce the occurrence of colon tumors and develop gut-associated lymphoid tissue in Min mice. Cancer Research 57, 225–228.Google ScholarPubMed
Pinto, MC, Garcia-Barrado, JA & Macias, P (1999) Resveratrol is a potent inhibitor of the dioxygenase activity of lipoxygenase. Journal of Agriculture and Food Chemistry 47, 4842–4846.CrossRefGoogle ScholarPubMed
Piyathilake, CJ, Macaluso, M, Johanning, GL, Whiteside, M, Heimburger, DC & Giuliano, A (2000) Methylenetetrahydrofolate reductase (MTHFR) polymorphism increases the risk of cervical intraepithelial neoplasia. Anticancer Research 20 (3A), 1751–1757.Google ScholarPubMed
Potter, JD (1997) Cancer prevention: epidemiology and experiment. Cancer Letters 114, 7–9.CrossRefGoogle ScholarPubMed
Ramos-Gomez, M, Kwak, MK, Dolan, PM, Itoh, K, Yamamoto, M, Talalay, P & Kensler, TW (2001) From the cover: sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice. Proceedings of the National Academy of Sciences USA 98, 3410–3415.CrossRefGoogle Scholar
Rampersaud, GC, Kauwell, GP, Hutson, AD, Cerda, JJ & Bailey, LB (2000) Genomic DNA methylation decreases in response to moderate folate depletion in elderly women. American Journal of Clinical Nutrition 72, 998–1003.CrossRefGoogle ScholarPubMed
Rao, CV, Chou, D, Simi, B, Ku, H & Reddy, BS (1998) Prevention of colonic aberrant crypt foci and modulation of large bowel microbial activity by dietary coffee fiber, inulin and pectin. Carcinogenesis 19, 1815–1819.CrossRefGoogle ScholarPubMed
Ratnasinghe, D, Tangrea, JA, Andersen, MR, Barrett, MJ, Virtamo, J, Taylor, PR & Albanes, D (2000) Glutathione peroxidase codon 198 polymorphism variant increases lung cancer risk. Cancer Research 60, 6381–6383.Google ScholarPubMed
Reddy, BS (1999) Possible mechanisms by which pro-and prebiotics influence colon carcinogenesis and tumor growth. Journal of Nutrition 129 (7 Suppl), 1478S–1482S.CrossRefGoogle ScholarPubMed
Reddy, BS, Hamid, R & Rao, CV (1997) Effect of dietary oligofructose and inulin on colonic preneoplastic aberrant crypt foci inhibition. Carcinogenesis 18, 1371–1374.CrossRefGoogle ScholarPubMed
Redman, C, Scott, JA, Baines, AT, Basye, JL, Clark, LC, Calley, C, Roe, D, Payne, CM & Nelson, MA (1998) Inhibitory effect of selenomethionine on the growth of three selected human tumor cell lines. Cancer Letters 125, 103–110.CrossRefGoogle ScholarPubMed
Roberfroid, M (1993) Dietary fiber, inulin, and oligofructose: a review comparing their physiological effects. Critical Reviews in Food Science and Nutrition 33, 103–148.CrossRefGoogle ScholarPubMed
Rose, DP & Connolly, JM (2000) Regulation of tumor angiogenesis by dietary fatty acids and eicosanoids. Nutrition and Cancer 37, 119–127.CrossRefGoogle ScholarPubMed
Sakai, T (2000) Biomarkers of lead exposure. Industrial Health 38, 127–142.CrossRefGoogle ScholarPubMed
Schatzkin, A, Lanza, E, Corle, D, Lance, P, Iber, F, Caan, B, Shike, M, Weissfeld, J, Burt, R, Cooper, MR, Kikendall, JW & Cahill, J (2000) Lack of effect of a low-fat, high-fiber diet on the recurrence of colorectal adenomas. Polyp Prevention Trial Study Group. New England Journal of Medicine 342, 1149–1155.CrossRefGoogle ScholarPubMed
Schrauzer, GN (2000) Anticarcinogenic effects of selenium. Cellular and Molecular Life Sciences 57, 1864–1867.CrossRefGoogle Scholar
Sinha, R, Said, TK & Medina, D (1996) Organic and inorganic selenium compounds inhibit mouse mammary cell growth in vitro by different cellular pathways. Cancer Letters 107, 277–284.CrossRefGoogle ScholarPubMed
Skibola, CF, Smith, MT, Kane, E, Roman, E, Rollinson, S, Cartwright, RA & Morgan, G (1999) Polymorphisms in the methylenetetrahydrofolate reductase gene are associated with susceptibility to acute leukemia in adults. Proceedings of the National Academy of Sciences USA 96, 12810–12815.CrossRefGoogle ScholarPubMed
Slattery, ML, Potter, JD, Samowitz, W, Schaffer, D & Leppert, M (1999) Methylenetetrahydrofolate reductase, diet, and risk of colon cancer. Cancer Epidemiology Biomarkers and Prevention 8, 513–518.Google ScholarPubMed
Smith-Warner, SA, Spiegelman, D, Yaun, SS, Adami, HO, Beeson, WL, van den Brandt, PA, Folsom, AR, Fraser, GE, Freudenheim, JL, Goldbohm, RA, Graham, S, Miller, AB, Potter, JD, Rohan, TE, Speizer, FE, Toniolo, P, Willett, WC, Wolk, A, Zeleniuch-Jacquotte, A & Hunter, DJ (2001) Intake of fruits and vegetables and risk of breast cancer: a pooled analysis of cohort studies. Journal of the American Medical Association 285, 769–776.CrossRefGoogle ScholarPubMed
Subbaramaiah, K, Michaluart, P, Chung, WJ, Tanabe, T, Telang, N & Dannenberg, AJ (1999) Resveratrol inhibits cyclooxygenase-2 transcription in human mammary epithelial cells. Annals New York Academy of Sciences 889, 214–223.CrossRefGoogle ScholarPubMed
Suk, WA & Collman, GW (1988) Genes and the environment: their impact on children's health. Environmental Health Perspective 106, 817–820.Google Scholar
Taper, HS & Roberfroid, M (1999) Influence of inulin and oligofructose on breast cancer and tumor growth. Journal of Nutrition 129 (7 Suppl), 1488S–1491S.CrossRefGoogle ScholarPubMed
Van Duyn, MA & Pivonka, E (2000) Overview of the health benefits of fruit and vegetable consumption for the dietetics professional: selected literature. Journal of the American Dietetic Association 100, 1511–1521.CrossRefGoogle ScholarPubMed
Vineis, P, Malats, N, Lang, M, d'Errico, A, Caporaso, N, Cuzick, J & Boffetta, P (editors) (1999) Metabolic Polymorphisms and Susceptibility to Cancer, pp. 1–510. Lyon, France: International Agency for Research on Cancer.Google ScholarPubMed
Ward, WE, Jiang, FO & Thompson, LU (2000) Exposure to flaxseed or purified lignan during lactation influences rat mammary gland structures. Nutrition and Cancer 37, 187–192.CrossRefGoogle ScholarPubMed
Wargovich, MJ (1999) Nutrition and cancer: the herbal revolution. Current Opinion in Clinical Nutrition Metabolic Care 2, 421–424.CrossRefGoogle ScholarPubMed
Weisburger, JH (2000) Prevention of cancer and other chronic diseases worldwide based on sound mechanisms. Biofactors 12, 73–81.CrossRefGoogle ScholarPubMed
Whiteley, LO & Klurfeld, DM (2000) Are dietary fiber-induced alterations in colonic epithelial cell proliferation predictive of fiber's effect on colon cancer? Nutrition and Cancer 36, 131–149.CrossRefGoogle ScholarPubMed
Woodson, K, Ratnasinghe, D, Bhat, NK, Stewart, C, Tangrea, JA, Hartman, TJ, Stolzenberg-Solomon, R, Virtamo, J, Taylor, PR & Albanes, D (1999) Prevalence of disease-related DNA polymorphisms among participants in a large cancer prevention trial. European Journal of Cancer Prev 8, 441–447.CrossRefGoogle Scholar
Wynder, EL & Gori, GB (1977) Contribution of the environment to cancer incidence: an epidemiologic exercise. Journal of the National Cancer Institute 58, 825–832.CrossRefGoogle ScholarPubMed
Zhou, JR, Gugger, ET, Tanaka, T, Guo, Y, Blackburn, GL & Clinton, SK (1999) Soybean phytochemicals inhibit the growth of transplantable human prostate carcinoma and tumor angiogenesis in mice. Journal of Nutrition 129, 1628–1635.CrossRefGoogle ScholarPubMed
Zhu, K & Williams, SM (1998) Methyl-deficient diets, methylated ER genes and breast cancer: an hypothesized association. Cancer Causes Control 9, 615–620.CrossRefGoogle ScholarPubMed
Zhu, Z, Jiang, W, Ganther, HE, Ip, C & Thompson, HJ (2000) In vitro effects of Se-allylselenocysteine and Se-propylselenocysteine on cell growth, DNA integrity, and apoptosis. Biochemical Pharmacology 60, 1467–1473.CrossRefGoogle ScholarPubMed