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Stimulation of muscle growth by clenbuterol: lack of effect on muscle protein biosynthesis

Published online by Cambridge University Press:  09 March 2007

Peter J. Reeds ,
Susan M. Hay ,
Patricia M. Dorwood  and
Robert M. Palmer
Peter J. Reeds
Affiliation:
Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
Susan M. Hay
Affiliation:
Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
Patricia M. Dorwood
Affiliation:
Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
Robert M. Palmer
Affiliation:
Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
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Abstract

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1. Young rats were offered to appetite a semi-synthetic diet either alone or containing the β2-selective agonist clenbuterol (4-amino-α[t-butylamino) methyl]-3, 5-dichlorobenzyl alcohol).

3. Male rats (starting weight 53 g) received clenbuterol at a daily oral dose of 200 pg/kg body-weight per d. Animals were slaughtered after 0, 4, 8, 11, 18, 21 and 25 d of treatment. At 4, 11, 21 and 25 d muscle protein synthesis was measured by the method of Garlick et al. (1980). Although clenbuterol increased the rate of protein and RNA accretion in gastrocnemius and soleus muscles, protein synthesis was not increased.

4. The results suggested that the drug had a rapid, perhaps direct, inhibitory effect on protein degradation. It is concluded that the growth-promoting effect of clenbuterol may be specific to muscle and that the drug may act in a novel manner which circumvents the physiological mechanisms responsible for the control of muscle growth.

Type
Papers on General Nutrition
Information
British Journal of Nutrition , Volume 56 , Issue 1 , July 1986 , pp. 249 - 258
Copyright
Copyright © The Nutrition Society 1986

References

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