Hostname: page-component-cd9895bd7-hc48f Total loading time: 0 Render date: 2024-12-25T02:21:00.144Z Has data issue: false hasContentIssue false
  • English
  • Français

Soya intake and plasma concentrations of daidzein and genistein: validity of dietary assessment among eighty British women (Oxford arm of the European Prospective Investigation into Cancer and Nutrition)

Published online by Cambridge University Press:  09 March 2007

Pai K. Verkasalo ,
Paul N. Appleby ,
Naomi E. Allen ,
Gwyneth Davey ,
Herman Adlercreutz  and
Timothy J. Key
Pai K. Verkasalo*
Affiliation:
Imperial Cancer Research Fund, Cancer Epidemiology Unit, University of Oxford, Oxford, UK
Paul N. Appleby
Affiliation:
Imperial Cancer Research Fund, Cancer Epidemiology Unit, University of Oxford, Oxford, UK
Naomi E. Allen
Affiliation:
Imperial Cancer Research Fund, Cancer Epidemiology Unit, University of Oxford, Oxford, UK
Gwyneth Davey
Affiliation:
Imperial Cancer Research Fund, Cancer Epidemiology Unit, University of Oxford, Oxford, UK
Herman Adlercreutz
Affiliation:
Institute for Preventive Medicine, Nutrition and Cancer, the Folkhälsan Research Center, Helsinki, Finland Department of Clinical Chemistry, University of Helsinki, Helsinki, Finland
Timothy J. Key
Affiliation:
Imperial Cancer Research Fund, Cancer Epidemiology Unit, University of Oxford, Oxford, UK
*
*Corresponding author: Dr Pia K. Verkasalo, fax +44 1865 310 545, email [email protected]
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Soya products contain high levels of the isoflavones genistein and daidzein, and their glucosides, and may lower the risk of cardiovascular disease, osteoporosis and cancer. The present cross-sectional study investigated plasma concentrations of daidzein and genistein and their correlations with dietary soya consumption in four groups of twenty premenopausal British women. The women were selected from the Oxford arm of the European Prospective Investigation into Cancer and Nutrition using data from food-frequency questionnaires (FFQ) to guarantee a wide variation in soya consumption, and to investigate the utility of the question related to soya milk consumption compared with the utility of the question related to other soya foods. Dietary intakes of isoflavones were additionally assessed by 7 d food diaries. Plasma concentrations of daidzein and genistein were measured by time-resolved fluoroimmunoassay. Geometric mean plasma concentrations (nmol/l) were for the four groups, which were based on increasing soya intake, 4·9, 8·4, 39·2 and 132 for daidzein and 14·3, 16·5, 119 and 378 for genistein. The Spearman correlation coefficients for plasma isoflavone concentrations with estimated dietary intakes were between 0·66 and 0·80 for the diary-based estimates and between 0·24 and 0·74 for the FFQ-based estimates. The correlations for soya milk intakes were clearly higher than the correlations for intakes of other soya foods. We conclude that both the food diary and the FFQ estimate dietary soya isoflavone intakes sufficiently well to use them in epidemiological studies, and that plasma concentrations of daidzein and genistein in Western women who consumed soya products as a part of their regular diet were close to those in Asian populations.

Keywords

Diet recordsIsoflavones in bloodQuestionnairesSoyabeans
Type
Research Article
Information
British Journal of Nutrition , Volume 86 , Issue 3 , September 2001 , pp. 415 - 421
Copyright
Copyright © The Nutrition Society 2001

References

Adlercreutz, H, Fotsis, T, Lampe, J, Wähälä, K, Mäkelä, T, Brunow, G & Hase, T (1993 a) Quantitative determination of lignans and isoflavonoids in plasma of omnivorous and vegetarian women by isotope dilution gas chromatography–mass spectrometry. Scandinavian Journal of Clinical and Laboratory Investigations 53, Suppl. 215, 5–18.CrossRefGoogle Scholar
Adlercreutz, H, Markkanen, H & Watanabe, S (1993 b) Plasma concentrations of phyto-oestrogens in Japanese men. Lancet 342, 1209–1210.CrossRefGoogle ScholarPubMed
Adlercreutz, H & Mazur, W (1997) Phyto-oestrogens and Western diseases. Annals of Medicine 29, 95–120.CrossRefGoogle ScholarPubMed
Albertazzi, P, Pansini, F, Bottazzi, M, Bonaccorsi, G, De Aloysio, D & Morton, MS (1999) Dietary soy supplementation and phytoestrogen levels. Obstetrics & Gynecology 94, 229–231.Google ScholarPubMed
Arai, Y, Uehara, M, Sato, Y, Kimira, M, Eboshida, A, Adlercreutz, H & Watanabe, S (2000) Comparison of isoflavones among dietary intake, plasma concentrations and urinary excretion for accurate estimation of phytoestrogen intake. Journal of Epidemiology 10, 127–135.CrossRefGoogle ScholarPubMed
Bingham, SA, Atkinson, C, Liggins, J, Bluck, L & Coward, A (1998) Phyto-oestrogens: where are we now? British Journal of Nutrition 79, 393–406.CrossRefGoogle ScholarPubMed
Bingham, SA, Gill, C, Welch, A, Cassidy, A, Runswick, SA, Oakes, S, Lubin, R, Thurnham, DI, Key, TJA, Roe, L, Khaw, K-T & Day, NE (1997) Validation of dietary assessment methods in the UK arm of EPIC using weighed records, and 24-hour urinary nitrogen and potassium and serum vitamin C and carotenoids as biomarkers. International Journal of Epidemiology 26, Suppl. 1, 137–151.CrossRefGoogle ScholarPubMed
Brzezinski, A, Adlercreutz, H, Shaoul, R, Rösler, A, Shmueli, A, Tanos, V & Schenker, JG (1997) Short-term effects of phytoestrogen-rich diet on postmenopausal women. Menopause 4, 89–94.CrossRefGoogle Scholar
Coward, L, Kirk, M, Albin, N & Barnes, S (1996) Analysis of plasma isoflavones by reversed-phase HPLC-multiple reaction monitoring-mass spectrometry. Clinica Chimica Acta 121, 121–142.CrossRefGoogle Scholar
Fournier, DB, Erdman, JWJ & Gordon, GB (1998) Soy, its components, and cancer prevention: a review of the in vitro, animal, and human data. Cancer Epidemiology, Biomarkers & Prevention 7, 1055–1065.Google ScholarPubMed
Gooderham, MH, Adlercreutz, H, Ojala, ST, Wähälä, K & Holub, BJ (1996) A soy protein isolate rich in genistein and daidzein and its effects on plasma isoflavone concentrations, platelet aggregation, blood lipids and fatty acid composition of plasma phospholipid in normal men. Journal of Nutrition 126, 2000–2006.Google Scholar
Greenstein, J, Kushi, L, Zheng, W, Fee, R, Campbell, D, Sellers, T & Folsom, A (1996) Risk of breast cancer associated with intake of specific foods and food groups. American Journal of Epidemiology 143, Suppl., 36.Google Scholar
Hubbuch, A & Schuckliess, F (1989) Quality Assurance. Interference by Haemolysis, Mannheim, Germany: Boehringer Mannheim.Google Scholar
International Agency for Research on Cancer (2000). International Agency for Research on Cancer Database. http://www.dep.iarc.fr/dataava/dataicon.htm.Google Scholar
Jacobsen, BK, Knutsen, SF & Fraser, GE (1998) Does high soy milk intake reduce prostate cancer incidence? The Adventist Health Study (United States). Cancer Causes and Control 9, 553–557.CrossRefGoogle ScholarPubMed
Key, TJ, Sharp, GB, Appleby, PN, Beral, V, Goodman, MT, Soda, M & Mabuchi, K (1999) Soya foods and breast cancer risk: a prospective study in Hiroshima and Nagasaki, Japan. British Journal of Cancer 81, 1248–1256.CrossRefGoogle Scholar
Messina, M (1995) Isoflavone intakes by Japanese were overestimated. American Journal of Clinical Nutrition 62, 645.CrossRefGoogle ScholarPubMed
Morton, MS, Chan, PSF, Cheng, C, Blacklock, N, MatosFerreira, A, AbranchesMonteiro, L, Correia, R, Lloyd, S & Griffiths, K (1997) Lignans and isoflavonoids in plasma and prostatic fluid in men: samples from Portugal, Hong Kong, and the United Kingdom. Prostate 32, 122–128.3.0.CO;2-O>CrossRefGoogle ScholarPubMed
Morton, MS, Wilcox, G, Wahlqvist, ML & Griffiths, K (1994) Determination of lignans and isoflavonoids in human female plasma following dietary supplementation. Journal of Endocrinology 142, 251–259.CrossRefGoogle ScholarPubMed
Setchell, KDR (1998) Phytoestrogens: the biochemistry, physiology, and implications for human health of soy isoflavones. American Journal of Clinical Nutrition 68, Suppl., 1333–1346.Google ScholarPubMed
US Department of Agriculture–Iowa State University (1999). Database on Isoflavone Content of Foods http://warp.nal.usda.gov/fnic/foodcomp/Data/isoflav/isoflav.html.Google Scholar
Wang, GJ, Lapcik, O, Hampl, R, Uehara, M, Al-Maharik, N, Stumpf, K, Mikola, H, Wähälä, K & Adlercreutz, H (2000) Time-resolved fluoroimmunoassay of plasma daidzein and genistein. Steroids 65, 339–348.CrossRefGoogle Scholar
Watanabe, S, Yusuke, A, Haba, R, Uehara, M, Adlercreutz, H, Shimoi, K & Kinae, N (2000) Dietary intake of flavonoids and isoflavonoids by Japanese and their pharmacokinetics and bioactivities. In Phytochemicals and Phytopharmaceuticals, pp. 164–174 [Shahidi, F and Ho, C-T, editors]. Champaign, IL: AOCS Press.Google Scholar
Zeleniuch-Jacquotte, A, Adlercreutz, H, Akhmedkhanov, A & Toniolo, P (1998) Reliability of serum measurements of lignans and isoflavonoid phytoestrogens over a two-year period. Cancer Epidemiology, Biomarkers and Prevention 7, 885–889.Google Scholar