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Soluble-fibre concentrate lowers plasminogen activator inhibitor-1 in baboons (Papio ursinus)

Published online by Cambridge University Press:  09 March 2007

C. S. Venter ,
C. J. Nel ,
H. H. Vorster ,
J. C. Jerling ,
W. Oosthuizen ,
F. J. Veldman ,
J. A. Kellerman ,
C. M. Smuts ,
W. J. H. Vermaak  and
D. G. Van Der Nest
...Show all authors
C. S. Venter
Affiliation:
Nutrition Research Group, Potchefstroom University, Potchefstroom, South Africa
C. J. Nel
Affiliation:
Nutrition Research Group, Potchefstroom University, Potchefstroom, South Africa
H. H. Vorster
Affiliation:
Nutrition Research Group, Potchefstroom University, Potchefstroom, South Africa
J. C. Jerling
Affiliation:
Nutrition Research Group, Potchefstroom University, Potchefstroom, South Africa
W. Oosthuizen
Affiliation:
Nutrition Research Group, Potchefstroom University, Potchefstroom, South Africa
F. J. Veldman
Affiliation:
Nutrition Research Group, Potchefstroom University, Potchefstroom, South Africa
J. A. Kellerman
Affiliation:
Nutrition Research Group, Potchefstroom University, Potchefstroom, South Africa
C. M. Smuts
Affiliation:
National Research Programme for Nutritional Intervention, Tygerberg, South Africa
W. J. H. Vermaak
Affiliation:
Department of Chemical Pathology, University of Pretoria, South Africa
D. G. Van Der Nest
Affiliation:
Nutrition Research Group, Potchefstroom University, Potchefstroom, South Africa
J. H. Ridder
Affiliation:
Department of Biokinetics, Potchefstroom University, Potchefstroom, South Africa
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Abstract

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The effects of a soluble NSP (fibre) concentrate (SFC) on plasma fibrinogen and plasminogen activator inhibitor-1 (PAI-1), serum and liver lipids and lipoproteins and glucose tolerance were compared with those of bezafibrate (BF), a lipid-lowering drug, in obese baboons (Papio ursinus) The basal diet was a high-fat (37% of total energy), low-NSP (12.4 g/d) Westernized diet, supplemented for 8 weeks with either 20 SFCg/baboon per d or 6.7 mg BF/kg body weight per baboon per d. SFC supplementation significantly lowered PAI-1, total serum cholesterol, HDL-cholesterol and circulating free fatty acid levels. BF significantly lowered total serum cholesterol, but unexpectedly raised serum triacylglycerol levels. Although not statistically significant, the mean liver tricacylglycerol concentration of baboons fed on BF was lower than that of baboons fed on SFC supplements. These results suggest that: (1) the mechanism of action of the two cholesterol-lowering treatments differ, with BF having a liver triacylglycerol-lowering effect and (2) the SFC had additional beneficial effect on fibrinolysis by lowering PAI-1 levels.

Keywords

Soluble-fibre concentratePlasminogen activator inhibitor-1Baboons
Type
General Nutrition
Information
British Journal of Nutrition , Volume 78 , Issue 4 , October 1997 , pp. 625 - 637
Copyright
Copyright © The Nutrition Society 1997

References

REFERENCES

Anderson, J. W. & Bridges, S. R. (1984) Short-chain fatty acid fermentation products of plant fiber affect glucose metabolism of isolated rat hepatocytes. Proceedings of the Society for Experimental Biology and Medicine 177, 372–376.CrossRefGoogle ScholarPubMed
Arvill, A. & Boden, L. (1995) Effect of short-term ingestion of konjac glucomannan on serum cholesterol in healthy men. American Journal of Clinical Nutrition 61, 585–589.CrossRefGoogle ScholarPubMed
Bodkin, M. L., Hannah, J. S., Ortmeyer, J. K. & Hansen, B. C. (1993) Central obesity in rhesus monkeys: association with hyperinsulinemia, insulin resistance and hypertriglyceridemia? International Journal of Obesity 17, 53–61.Google ScholarPubMed
Brown, M., Venter, C. S., Vorster, H. H., Jerling, J. C., Oosthuizen, W. & van der Nest, D. G. (1995) Dietary fibre decreases some cardiovascular risk markers in an uremic rat model. South African Journal of Clinical Nutrition 8, 7–11.Google Scholar
Catapano, A. L. (1992) Mode of action of fibrates. Pharmacology Research 26, 331–340.CrossRefGoogle ScholarPubMed
Chen, W. J. L., Anderson, J. W. & Jennings, D. (1984) Propionate may mediate the hypocholesterolemic effects of certain soluble plant fibres in cholesterol-fed rats. Proceedings of the Society for Experimental Biology and Medicine 175, 215–218.CrossRefGoogle ScholarPubMed
Clauss, A. (1957) Gerinnungsphysiologishe Schnellmethode zur bestimming des Fibrinogens (Rapid method of clotting physiology for the characterization of the fibrinogens). Acta Haematologica 17, 237–246.CrossRefGoogle Scholar
Cummings, J. H., Pomare, E. W., Branch, W. J., Naylor, C. P. E. & MacFarlane, G. T. (1988) Short chain fatty acids in human large intestine, portal, hepatic and venous blood. Gut 28, 1221–1227.Google Scholar
Donahue, R. P., Abbott, R. D., Bloom, E., Reed, D. M. & Yano, J. (1987) Central obesity and coronary heart disease in men. Lancet i, 987–988.Google Scholar
Donahue, R. P., Orchard, T. J., Becker, D. J., Kuller, L. H. & Drash, A. L. (1988) Physical activity, insulin sensitivity, and the lipoprotein profile in young adults: the Beaver County study. American Journal of Epidemiology 127, 95–103.CrossRefGoogle ScholarPubMed
Ebihara, K., Masuhara, R. & Kiriyama, S. (1981) Effect of konjac-mannan, a water soluble dietary fiber, on plasma glucose and insulin responses in young men undergoing glucose tolerance tests. Nutrition Reports International 23, 577–583.Google Scholar
Folch, J., Lees, M. & Sloane-Stanley, G. H. (1957) A simple method for the isolation and purification of total lipides from animal tissues. Journal of Biological Chemistry 226, 497–509.CrossRefGoogle ScholarPubMed
Fontbonne, A. & Eschwege, E. (1987) Diabetes, hyperglycaemia, hyperinsulinaemia and atherosclerosis: epidemiological data. Diabete et Metabolisme 13, 350–353.Google ScholarPubMed
Frohn, M. J. N. (1976) Left leg varicose veins and deep-vein thrombosis. Lancet ii, 1019–1020.CrossRefGoogle Scholar
Gandrille, S. & Aiach, M. (1990) Albumin concentration influences fibrinolytic activity in plasma and purified systems. Fibrinolysis 4, 225–232.CrossRefGoogle Scholar
Hamsten, A., Wiman, B., de Faire, U. & Blombäck, M. (1985) Increased plasma levels of a rapid inhibitor of tissue plasminogen activator in young survivors of myocardial infarction. New England Journal of Medicine 313, 1552–1563.CrossRefGoogle ScholarPubMed
Itaya, K. & Ui, M. (1966) A new micromethod for the colorimetric determination of inorganic phosphate. Clinica Chimica Acta 14, 361–366.CrossRefGoogle ScholarPubMed
Jenkins, D. J. A., Wolever, T. M. S., Nineham, R., Sarson, D. L., Bloom, S. R., Ahern, J., Alberti, K. G. M. & Hockaday, T. D. R. (1980) Improved glucose tolerance four hours after taking guar with glucose. Diabetologia 19, 21–24.Google Scholar
Juhan-Vague, I., Alessi, M. C., Joly, P., Thirion, X., Vague, P., Declerck, P. J., Serradimigni, A. & Collen, D. (1989) Plasma plasminogen activator inhibitor-1 in angina pectoris. Influence of plasma insulin and acute-phase response. Arteriosclerosis 9, 362.Google ScholarPubMed
Kannel, W. B., D'Agostino, R. B. & Belanger, A. C. (1987) Fibrinogen, cigarette smoking and risk of cardiovascular disease: insights from the Framingham study. American Heart Journal 113, 1006–1010.CrossRefGoogle ScholarPubMed
Karhapää, P., Uusitupa, M., Voutilainen, E. & Laasko, M. (1992) Effects of bezafibrate on insulin sensitivity and glucose tolerance in subjects with combined hyperlipidemia. Clinical Pharmacology and Therapeutics 52, 620–626.CrossRefGoogle ScholarPubMed
Keber, I., Lavre, J., Suc, S & Keber, D. (1994) The decrease of plasminogen activator inhibitor after normalization of triglycerides during treatment with fibrates. Fibrinolysis 8, 57–59.CrossRefGoogle Scholar
Kemnitz, J. W., Goy, R. W., Flitsch, T. J., Lohmiller, J. J. & Robinson, J. A. (1989) Obesity in male and female rhesus monkeys: fat distribution, glucoregulation and serum androgen levels. Journal of Clinical Endocrinology and Metabolism 69, 287–293.CrossRefGoogle ScholarPubMed
Khodabandehlou, T. & Le Devehat, C (1990) Role of albumin and fibrinogen on red cell aggregation – disaggregation in diabetes mellitus. Clinical Hemorheology 10, 557–560.Google Scholar
Kissebah, A. H., Adams, P. W., Harrigan, P. & Wynn, V. (1974) The mechanism of action of clofibrate and tetranicotinoylfructose (bradilan) on the kinetics of plasma free fatty acid and triglyceride transport in type IV and type V hypertriglyceridaemia. European Journal of Clinical Investigation 4, 163–174.CrossRefGoogle ScholarPubMed
Koepp, P & Hegewisch, S. (1981) Effects of guar on plasma viscosity and related parameters in diabetic children. European Journal of Pediatrics 137, 31–33.CrossRefGoogle ScholarPubMed
Landin, K., Holm, G., Tengborn, L. & Smith, U. (1992) Guar gum improves insulin sensitivity, blood lipids, blood pressure, and fibrinolysis in healthy men. American Journal of Clinical Nutrition 56, 1061–1065.CrossRefGoogle ScholarPubMed
Landin, K., Stigendal, L. & Eriksson, E. (1990 a) Abdominal obesity is associated with an impaired fibrinolytic activity and elevated plasminogen activator inhibitor 1. Metabolism 39, 1044–1048.CrossRefGoogle ScholarPubMed
Landin, K., Tengborn, L. & Smith, U. (1990 b) Elevated fibrinogen and plasminogen activator inhibitor (PAI-1) in hypertension are related to metabolic risk factors for cardiovascular disease. Journal of Internal Medicine 227, 273–278.CrossRefGoogle ScholarPubMed
Langenhoven, M., Kruger, M., Gouws, E. & Faber, M. (1991) MRC Food Composition Tables. Parow: MRC.Google Scholar
Latto, C. (1976) Postoperative deep-vein thrombosis, pulmonary embolism, and high-fibre diet (letter). Lancet ii, 1197.CrossRefGoogle Scholar
Malhotra, S. L. (1968) Studies on blood coagulation, diet, and ischaemic heart disease in two population groups in India. British Heart Journal 30, 303–308.CrossRefGoogle ScholarPubMed
Markwell, M. A. K., Haas, S. M., Bieber, L. L. & Tolbert, N. E. (1978) A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples, Analytical Biochemistry 87, 206–210.Google Scholar
Meade, T. W., Brozovic, M., Chakrabarti, R. R., Haines, A. P., Imeson, J. D., Mellows, S., Miller, G. J., North, W. R. S., Stirling, Y. & Thompson, S. B. (1986) Haemostatic function and ischaemic heart disease: principal results of the Northwick Park Heart Study. Lancet ii, 533–537.CrossRefGoogle Scholar
Mehrabian, M., Peter, J. B., Barnard, R. J. & Lusis, A. J. (1990) Dietary regulation of fibrinolytic factors. Atherosclerosis 84, 25–32.Google Scholar
Mehta, J., Mehta, P., Lawson, D. & Saldeen, T. (1987) Plasminogen activator inhibitor levels in coronary artery disease: correlation with age and serum triglyceride concentrations. Journal of the American College of Cardiology 9, 263–268.CrossRefGoogle ScholarPubMed
Pilgeram, L. O. & Pickart, L. R. (1968) Control of fibrinogen bio-synthesis: the role of free fatty acid. Atherosclerosis Research 8, 155–166.CrossRefGoogle Scholar
Reaven, G.-M. (1988) Role of insulin resistance in human disease. Diabetes 37, 1595–1607.Google ScholarPubMed
Reeder, J. A., Dickinson, J. L., Chenevix-Trench, G. & Antalis, T. M. (1993) Sodium butyrate differentially modulates plasminogen activator inhibitor type-1, urokinase plasminogen activator, and its receptor in a human colon carcinoma cell. Teratogenesis Carcinogenesis Mutagenesis 13, 75–88.CrossRefGoogle Scholar
Simpson, H. C. R., Mann, J. I., Chakrabarti, R., Imeson, J. D., Stirling, Y., Tozer, M., Woolf, L. & Meade, T. W. (1982) Effect of high fibre diet on haemostatic variables in diabetes. British Medical Journal 284, 1608.CrossRefGoogle ScholarPubMed
Skipski, V. P., Smolowe, A. F., Sullivan, R. C. & Barclay, M. (1965) Separation of lipid classes by thin-layer chromatography. Biochimica et Biophysica Acta 106, 386–396.CrossRefGoogle ScholarPubMed
Smuts, C. M., Kruger, M., van Jaarsveld, P. J., Fincham, J. E., Schall, R., van der Merwe, K. J. & Benade, A. J. S. (1992) The influence of fish oil supplementation on plasma lipoproteins and arterial lipids in ervet monkeys with established atherosclerosis. Prostaglandins Leukotrienes & Essential Fatty Acids 47, 129–138.CrossRefGoogle Scholar
Southgate, D. A. T. (1976) The chemistry of dietary fibre. In Fibre in Human Nutrition, pp. 31–72 [Spiller, G.A., Amen, R. J., editors]. New York: Plenum.CrossRefGoogle Scholar
Stahlberg, D. (1992) Effects of bezafibrate – a hypolipidemic drug. Cardiovascular Drug Reviews 10, 259–279.CrossRefGoogle Scholar
Statsoft, Inc. (1996) STATISTICA for Windows. Tulsa, OK: Statsoft Inc.Google Scholar
Stegmeier, K., Stork, H., Lenz, H., Leuschner, F. & Liede, V. (1980) Pharmacology and mode of action of bezafibrate in animals. In Lipoproteins and Coronary Heart Disease, pp. 76–82 [Greten, H., Lang, P. D. and Schettler, G., editors]. Baden-Baden, Germany: Gerhard Witzstrock Publishing House.Google Scholar
Sundell, I. B., Dahlgren, S., Rånby, M., Lundin, E., Stenling, R & Nilson, T. K. (1989) Reduction of elevated plasminogen activator inhibitor levels during modest weight loss. Fibrinolysis 23, 45–50.Google Scholar
Sundell, I. B. & Rånby, M. (1993) Oat husk fiber decreases plasminogen activator inhibitor type 1 activity. Haemostasis 23, 45–50.Google ScholarPubMed
Venter, C. S., Kruger, H. S., Vorster, H. H., Serfontein, W. J., Ubbink, J. B. & de Villiers, L. S. (1987) The effects of the dietary fibre component konjac-glucomannan on serum cholesterol levels of hypercholester-olaemic subjects. Human Nutrition: Food Science and Nutrition 41F, 55–61.Google Scholar
Venter, C. S., Vorster, H. H. & van der Nest, D. G. (1990) Comparison between physiological effects of konjac-glucomannan and propionate in baboons fed western diets. Journal of Nutrition 120, 1046–1053.CrossRefGoogle ScholarPubMed
Venter, C. S., Vorster, H. H., van der Nest, D. G. & Wight, A. W. (1991) Effects of konjac-glucomannan and propionate on plasma fibrinogen and serum and liver lipids in Zucker rats. South African Journal of Clinical Nutrition 4, 6–11.Google Scholar
Vorster, H. H. & de Jager, J. (1984) The effect of the long-term ingestion of konjac-glucomannan on glucose tolerance and immunoreactive insulin values of baboons. South African Medical Journal 65, 805–808.Google ScholarPubMed
Vorster, H. H., Kruger, H. S., Frylinck, S., Botha, B. J., Lombaard, W. A. & de Jager, J. (1985) Physiological effects of the dietary fibre component konjac-glucomannan in rats and baboons. Journal of Plant Foods 6, 263–274.CrossRefGoogle Scholar
Vorster, H. H., Venter, C. S., van Eeden, T. S., Silvis, N., Huisman, H. W., van Ryssen, J. C. J. & Walker, A. R. P. (1988) Benefits from supplementation of the current recommended diabetic diet with gel fibre. International Clinical Nutrition Review 8, 140–146.Google Scholar
Watanabe, T., Horie, S., Yamada, J., Isaji, M., Nishigaki, T., Naito, J. & Suga, T. (1989) Species differences in the effects of bezafibrate, a hypolipidemic agent, on hepatic peroxisome-associated enzymes. Biochemical Pharmacology 38, 367–371.Google ScholarPubMed
Wilhelmsen, L., Svärdsudd, K., Korsan-Bengsten, K., Larsson, B., Welin, L & Tibblin, G. (1984) Fibrinogen as a risk factor for stroke and myocardial infarction. New England Journal of Medicine 311, 501–505.CrossRefGoogle ScholarPubMed