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Short-term effects of dietary sodium intake on bone metabolism in postmenopausal women measured using urinary deoxypyridinoline excretion

Published online by Cambridge University Press:  09 March 2007

Georg Lietz ,
Alison Avenell  and
Simon P Robins
Georg Lietz
Affiliation:
The Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB
Alison Avenell
Affiliation:
The Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB
Simon P Robins
Affiliation:
The Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB
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Abstract

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The influence of Na load on bone metabolism was investigated in postmenopausal women using urinary deoxypyridinoline (DPD) as a marker of bone resorption. In a cross-over study, fourteen postmenopausal women were divided into two groups of seven. A fixed diet providing 816 mg Ca/d with either 60 or 170 mmol Na/d was consumed. At the end of an 8 d period the groups switched diets for a further 8d period. Urine was collected daily for the last 4d of each period. There was no significant difference in DPD excretion between high-Na and low-Na diets (129 nmol/d v. 132 nmol/d; P = 0·18). There was, however, a significant relationship (P = 0·02) between the changes in DPD excretion and urinary Ca. Plasma Mg fell from 0·83 to 0·81mmol/l on the high Na intake (P<0·001), but there was no significant effect on plasma Ca or intact parathyroid hormone levels. It is concluded that varying dietary Na intake may affect Ca and Mg metabolism, but we were unable to demonstrate an effect on bone resorption at the levels of intake used

Keywords

DeoxypyridinolineSodiumBonePostmenopausal women
Type
Human and Clinical Nutrition
Information
British Journal of Nutrition , Volume 78 , Issue 1 , July 1997 , pp. 73 - 82
Copyright
Copyright © The Nutrition Society 1997

References

REFERENCES

Bauder, P. J. (1981). Affinity and stoichiometry of calcium binding by arsernazo III. Analytical Biochemistry 110, 61–72.Google Scholar
Bolton-Smith, C., Smith, C. S., Woodward, M. & Turnstall-Pedoe, H. D. (1991). Nutrient intakes of different social-class groups: results from the Scottish Heart Health Study (SHHS). British Journal of Nutrition 65, 321–335.CrossRefGoogle ScholarPubMed
Breslau, N. A., McGuire, J. L., Zerwekh, J. E. & Pak, C. Y. (1982). The role of dietary sodium on renal excretion and intestinal absorption of calcium and on vitamin D metabolism. Journal of Clinical Endocrinology and Metabolism 55, 369–373.CrossRefGoogle ScholarPubMed
Breslau, N. A., Sakhaee, K. & Pak, C. Y. (1985). Impaired adaptation to salt-induced urinary calcium losses in postmenopausal osteoporosis. Transactions of the Association of American Physicians 98, 107–115.Google ScholarPubMed
Castenmiller, J. J., Mensink, R. P., van der Heijden, L., Kouwenhoven, T., Hautvast, J. G., de Leeuw, P. W. & Schaafsma, G. (1985). The effect of dietary sodium on urinary calcium and potassium excretion in normotensive men with different calcium intakes. American Journal of Clinical Nutrition 41, 52–60.CrossRefGoogle ScholarPubMed
Chan, E. L., Ho, C. S., MacDonald, D., Ho, S. C., Chan, T. Y. & Swaminathan, R. (1992). Interrelationships between urinary sodium, calcium, hydroxyproline and serum PTH in healthy subjects. Acta Endocrinologica 127, 242–245.Google ScholarPubMed
Colwell, A., Eastell, R., Assiri, A. M. & Russell, R. G. (1990). Effect of diet on deoxypyridinoline excretion. In Proceedings of the 3rd International Symposium on Osteoporosis, pp. 590–591 [Christiansen, C. and Overgaard, K., editors]. Copenhagen: Osteopress ApS.Google Scholar
Delmas, P. D. (1992). Clinical use of biochemical markers of bone remodeling in osteoporosis. Bone 13, S17–S21.CrossRefGoogle ScholarPubMed
Department of Health (1991). Dietary Reference Values for Food Energy and Nutrients for the United Kingdom. London: H. M. Stationery Office.Google Scholar
Eyre, D. (1992). Editorial: New biomarkers of bone resorption. Journal of Clinical Endocrinology and Metabolism 74, 470A–470C.CrossRefGoogle ScholarPubMed
Gitelman, H. J., Hurt, C. & Ludwak, L. (1966). An automated spectrophotometric method for magnesium analysis. Analytical Biochemistry 14, 106–120.CrossRefGoogle Scholar
Grinspoon, S. K., Baum, H.B.A., Kim, V., Coggins, C. & Klibanski, A. (1995). Decreased bone formation and increased mineral dissolution during acute fasting in young women. Journal of Clinical Endocrinology and Metabolism 80, 3628–3633.CrossRefGoogle ScholarPubMed
Lawes Agricultural Trust (1987) Genstat V. Rothamsted, Herts: Lawes Agricultural Trust.Google Scholar
Lemann, J. (1993). Urinary excretion of calcium, magnesium, and phosphorus. In Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, pp. 50–55 [Favus, M. J. editor]. New York: Raven Press.Google Scholar
McCarron, D. A., Rankin, L. I., Bennett, W. M., Krutzik, S., McClung, M. R. & Luft, F. C. (1981). Urinary calcium excretion at extremes of sodium intake in normal man. American Journal of Nephrology 1, 84–90.CrossRefGoogle ScholarPubMed
MacGregor, G. A. & Cappuccio, F. P. (1993). The kidney and essential hypertension: a link to osteoporosis? Journal of Hypertension 11, 781–785.CrossRefGoogle ScholarPubMed
McLaren, A. M., Isdale, A. H., Whiting, P. H., Bird, H. A. & Robins, S. P. (1993). Physiological variations in the urinary excretion of pyridinium crosslinks of collagen. British Journal of Rheumatology 32, 307–312.CrossRefGoogle ScholarPubMed
McParland, B.E., Goulding, A. & Campbell, A.J. (1989). Dietary salt affects biochemical markers of resorption and formation of bone in elderly women. British Medical Journal 299, 834–835.CrossRefGoogle ScholarPubMed
Ministry of Agriculture, Fisheries and Food (1991). Household Food Consumption and Expenditure 1990. London: H. M. Stationery Office.Google Scholar
Need, A. G., Morris, H. A., Cleghorn, D. B., Nichilo, D. D.Horowitz, M. & Nordin, B. E. C. (1991). Effect of salt restriction on urine hydroxyproline excretion in postmenopausal women. Archives of International Medicine 151, 757–759.CrossRefGoogle ScholarPubMed
Nordin, B. E. C. & Polley, K. J. (1987). Metabolic consequences of the menopause. Calcified Tissue International 41, Suppl. 1, Sl–S60.Google ScholarPubMed
Pesce, A. & Kaplan, L. A. (1987). Methods in Clinical Chemistry, pp. 1021. St Louis, MO: C. V. Mosby Co.Google Scholar
Pratt, D. A., Daniloff, Y., Duncan, A. & Robins, S. P. (1992). Automated analysis of the pyridinium crosslinks of collagen in tissue and urine using solid-phase extraction and reversed-phase high-performance liquid chromatography. Analytical Biochemistry 207, 168–175.CrossRefGoogle ScholarPubMed
Ray Sarkar, B. C. & Chauhan, U. P. (1967). A new method for determining micro quantities of calcium in biological materials. Analytical Biochemistry 20, 155–166.CrossRefGoogle Scholar
Reginster, J. Y., Strause, L., Deroisy, R., Lecart, M. P., Saltman, P. & Franchimont, P. (1989). Preliminary report of decreased serum magnesium in postmenopausal osteoporosis. Magnesium 8, 106–109.Google ScholarPubMed
Robins, S. P. (1982). Turnover and crosslinking of collagen. In Collagen in Health and Disease, pp. 160–178 [Weiss, J. B. and Jayson, M. I. editors]. Edinburgh: Churchill Livingstone.Google Scholar
Robins, S. P., Black, D., Paterson, C. R., Reid, D. M., Duncan, A. & Seibel, M. J. (1991). Evaluation of urinary hydroxypyridinium crosslink measurements as resorption markers in metabolic bone diseases. European Journal of Clinical Investigation 21, 310–315.CrossRefGoogle ScholarPubMed
Seelig, M. S. (1990). Increased need for magnesium with the use of combined oestrogen and calcium for osteoporosis treatment. Magnesium Research 3, 197–215.Google ScholarPubMed
Shortt, C., Madden, A., Flynn, A. & Morrissey, P. A. (1988). Influence of dietary sodium intake on urinary calcium excretion in selected Irish individuals. European Journal of Clinical Nutrition 42, 595–603.Google ScholarPubMed
Shortt, S. & Flynn, A. (1990). Sodium-calcium inter-relationships with specific reference to osteoporosis. Nutrition Research Reviews 3, 101–115.CrossRefGoogle ScholarPubMed
Slovik, D. M., Neer, R. M. & Potts, J. T. (1981). Short-term effects of synthetic human parathyroid hormone-(1–34) administration on bone mineral metabolism in osteoporotic patients. Journal of Clinical Investigation 68, 1261–1271.CrossRefGoogle Scholar
Smith, W. C., Crombie, I. K., Tavendale, R. T., Gulland, S. K. & Tunstall-Pedoe, H. D. (1988). Urinary electrolyte excretion, alcohol consumption and blood pressure in the Scottish Heart Health Study. British Medical Journal 297, 229–230.CrossRefGoogle ScholarPubMed
Southgate, D. A. T. (1969). Determination of carbohydrates in food II.—Unavailable carbohydrates. Journal of the Science of Food and Agriculture 20, 331–335.CrossRefGoogle ScholarPubMed
Stevens, D. L., Skeggs, L. T., Casson, A. L., Grady, H. J. & Stanley, M. A. (1953). Modification of the procedure of Folin and Wu. In Practical Physiological Chemistry, p. 506 [Hawk, P. B.Oser, B. L. and Summerson, W. H. editors]. Philadelphia: Blakiston.Google Scholar
Technicon Instruments Co. Ltd (1971). Auto Analyzer Sheet no. 11–07. Basingstoke: Technicon Instruments Co. Ltd.Google Scholar
Zarkadas, M., Gougeon Reyburn, R., Marliss, E. B., Block, E. & Alton Mackey, M. (1989). Sodium chloride supplementation and urinary calcium excretion in postmenopausal women. American Journal of Clinical Nutrition 50, 1088–1094.CrossRefGoogle ScholarPubMed