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Short-term dietary selenium restriction in young adults: quantitative studies with the stable isotope 74SeO32−

Published online by Cambridge University Press:  09 March 2007

Lynda J. Kasper ,
Vernon R. Young  and
Morteza Janghorbani
Lynda J. Kasper
Affiliation:
Laboratory of Human Nutrition, Department of Nutrition and Food Science, Cambridge, Massachusetts 02139, USA
Vernon R. Young
Affiliation:
Laboratory of Human Nutrition, Department of Nutrition and Food Science, Cambridge, Massachusetts 02139, USA
Morteza Janghorbani
Affiliation:
Laboratory of Human Nutrition, Department of Nutrition and Food Science, Cambridge, Massachusetts 02139, USA Nuclear Reactor Laboratory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
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Abstract

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1. A 45 d metabolic study was carried out in four young adult male North American residents consuming a controlled diet based on an amino acid mixture. During the initial 10 d, total daily selenium intake was adjusted to 107.7 (SE 0.1) μg/d, which was reduced to 11.4 (SE 0.1) μg/d for the remaining 35 d.

2. Two doses of a stable isotope (74SeO32-) were administered orally in the post-absorptive state on days 4 and 39 of the study.

3. Se balance (faecal + urinary excretion) as well as stable isotope excretion studies were carried out for the entire 45 d period; blood plasma and erythrocyte Se concentrations were also monitored.

4. Plasma Se concentrations (μg/ml) fell progressively from the initial value of 0.132 (SE 0.007) to 0.083 (SE 0.008) at the end of the study. The erythrocyte concentrations of Se did not vary in a consistent manner (average value for the entire study 0.147 (SE 0.002) μg/ml).

5. Faecal excretion of unenriched Se decreased from 66 (SE 6) μg/d for days 1–10 to 10.2 (SE 0.8) μg/d for days 14–40. Mean urinary excretions of the unenriched Se were 43.9 (SE 2.8) μg/d (days 1–10) and 26.9 (SE 4.6) μg/d (days 14–40). Total balance (intake - faecal excretion - urinary excretion) for unenriched Se was μg/d):-18 (SE 7) days 10–19, -17 (SE 2) days 19–39, -5 (SE 1) days 38–45.

6. Fractional absorption of the ingested label was 0.529 (SE 0.032) and 0.542 (SE 0.038) for the Se-adequate and Se-restricted phases of the study. However, urinary excretion of the absorbed label was reduced from 6.57 (SE 0.73)% for day 1 of the Se-adequate phase to only 3.32 (SE 0.26)% for day 1 of the Se-restricted phase. Similar observations were also made for day 7 of each phase.

7. These findings indicate that immediate contribution of ingested Se to the urinary Se pool is small.

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 52 , Issue 3 , November 1984 , pp. 443 - 455
Copyright
Copyright © The Nutrition Society 1984

References

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