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Serum thymic hormone activity in genetically-obese mice

Published online by Cambridge University Press:  09 March 2007

R. K. Chandra ,
Gloria Heresi  and
B. Au
R. K. Chandra
Affiliation:
Department of Pediatrics, Memorial University of Newfoundland, St John's, Newfoundland, Canada and Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
Gloria Heresi
Affiliation:
Department of Pediatrics, Memorial University of Newfoundland, St John's, Newfoundland, Canada and Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
B. Au
Affiliation:
Department of Pediatrics, Memorial University of Newfoundland, St John's, Newfoundland, Canada and Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
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Abstract

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1. Serum thymic hormone was assayed in genetically-obese (C57B1/6J ob/ob) mice and lean controls (+/+, +/−) of the same strain.

2. The thymic hormone activity was higher in the majority of the obese animals compared with non-obese mice.

3. The number of antibody-forming cells in the spleen expressed as a proportion of the total mononuclear cells was increased in the obese mice.

4. It is suggested that obesity is associated with significant changes in the thymic hormone levels which may alter the relative proportion of lymphocyte subsets and cell-mediated immunity.

Type
Short Paper
Information
British Journal of Nutrition , Volume 45 , Issue 1 , January 1981 , pp. 211 - 213
Copyright
Copyright © The Nutrition Society 1981

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