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Selenium supplementation affects the retention of stable isotopes of selenium in human subjects consuming diets low in selenium

Published online by Cambridge University Press:  09 March 2007

John W. Finley ,
Anna Duffield ,
Pengcheng Ha ,
Richard A. Vanderpool  and
Christine D. Thomson
John W. Finley*
Affiliation:
United States Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, Grand Forks, ND 58202,USA†
Anna Duffield
Affiliation:
Department of Human Nutrition, University of Otago, Dunedin, New Zealand
Pengcheng Ha
Affiliation:
Centre for Indigenous Peoples' Nutrition and Environment, McGill University, Ste-Anne-de-Bellevue, Quebec, H9X 3V9, Canada
Richard A. Vanderpool
Affiliation:
PO Box 3006,State UniversityArkansas 72467,USA
Christine D. Thomson
Affiliation:
Department of Human Nutrition, University of Otago, Dunedin, New Zealand
*
*Corresponding author: Dr J. W. Finley, fax +1 701 795 8395, email [email protected]
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Abstract

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Twenty-nine women and fifteen men from an area of low Se intake (South Island of New Zealand) consumed 100 μg stable 74Se, as selenate given in water after an overnight fast, and blood was collected for 3 weeks. They were then divided into five groups and supplemented with 0, 10, 20, 30 and 40 μg Se/d (as selenomethionine) for 5 months. After 5 months, they received a second dose of 74Se identical to the first. Supplementation significantly altered retention of 74Se in the plasma, but not in the erythrocytes or platelets. Subjects receiving the placebo retained the greatest amount, and subjects receiving 30 μg supplemental Se/d retained the least 74Se. Supplementation resulted in relatively more isotope being retained in a medium molecular mass protein considered to be albumin, and relatively less in another fraction considered to be selenoprotein P. The lack of many observed changes in retention of stable Se, and the shift in retention among the plasma proteins, suggests that supplemental Se was not being used to replete critical pools of Se, probably because of adaptation to low Se intake.

Keywords

SeleniumStable isotopes
Type
Short communication
Information
British Journal of Nutrition , Volume 82 , Issue 5 , November 1999 , pp. 357 - 360
Copyright
Copyright © The Nutrition Society 1999

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