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Selenium and breast-feeding

Published online by Cambridge University Press:  09 March 2007

Jose G. Dorea
Jose G. Dorea*
Affiliation:
Department of Nutrition, Universidade de Brasilia, 70919.970, Brasilia, Brazil
*
*Corresponding author: Professor Jose G. Dorea, fax +55 61 368 5853, email [email protected]
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Abstract

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The objective of the present review is to discuss Se nutrition during breast-feeding, encompassing environmental and maternal constitutional factors affecting breast-milk-Se metabolism and secretion. A literature search of Medline and Webofscience was used to retrieve and select papers dealing with Se and breast milk. Although Se in natural foods occurs only in organic form, breast milk responds to organic and inorganic Se in supplements. Inorganic Se (selenite, selenate), which is largely used in maternal supplements, is not detectable in breast milk. The mammary-gland regulating mechanism controls the synthesis and secretion of seleno-compounds throughout lactation, with a high total Se level in colostrum that decreases as lactation progresses. Se appears in breast milk as a component of specific seleno-proteins and seleno-amino-acids in milk proteins that are well tolerated by breast-fed infants even in high amounts. Se in breast milk occurs as glutathione peroxidase (4–32% total Se) > selenocystamine > selenocystine > selenomethionine. The wide range of breast-milk Se concentrations depends on Se consumed in natural foods, which reflects the Se content of the soils where they are grown. Se prophylaxis, either through soil Se fertilization or maternal supplements, is effective in raising breast-milk Se concentration. In spite of wide variation, the median Se concentration from studies worldwide are 26, 18, 15, and 17 μg/l in colostrum (0–5 d), transitional milk (6–21 d), mature milk (1–3 months) and late lactation (>5 months) respectively. Se recommendations for infants are presently not achieved in 30% of the reported breast-milk Se concentrations; nevertheless Se status is greater in breast-fed than in formula-fed infants.

Keywords

SeleniumLactationSpeciationGlutathione peroxidase
Type
Review article
Information
British Journal of Nutrition , Volume 88 , Issue 5 , November 2002 , pp. 443 - 461
Copyright
Copyright © The Nutrition Society 2002

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