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The role of propionate and acetate in the control of food intake in sheep

Published online by Cambridge University Press:  09 March 2007

D. A. H. Farningham  and
C. C. Whyte
D. A. H. Farningham
Affiliation:
The Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB2 9SB
C. C. Whyte
Affiliation:
The Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB2 9SB
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Abstract

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Sheep fed ad lib. on a good-quality pelleted diet (g/kg; hay 500, barley 300, molasses, fish meal and minerals) were infused via the hepatic portal vein with mixtures of the sodium salts of volatile fatty acids, acetate and propionate, and a variety of equivalent osmotic loads. Propionate infused at rates between 0·6 and 2·5 mmol/min consistently reduced food intake in a linear, dose-related manner. Propionate infusions resulted in consistent dose-related increases in peripheral venous plasma glucose concentration but variable changes in insulin concentration. Infusion of osmotically balanced mixtures of propionate, acetate, mannitol or saline (9 g NaCI/I) indicated that at constant osmotic loading propionate caused a greater reduction in intake than other infusions. Acetate infusions only depressed food intake when administered as a 1 M solution. Lower concentrations had little effect, similar to that of equivalent osmotic loads of mannitol or saline. It is concluded that portal propionate flow has a potential role in the control of food intake in ruminants which is independent of osmotic effects or changes in plasma insulin concentration.

Keywords

Food intakePropionateSheep
Type
Control of Feed Intake in Sheep
Information
British Journal of Nutrition , Volume 70 , Issue 1 , July 1993 , pp. 37 - 46
Copyright
Copyright © The Nutrition Society 1993

References

REFERENCES

Anil, M. H. & Forbes, J. M. (1980). Feeding in sheep during intraportal infusions of short-chain fatty acids and the effect of liver denervation. Journal of Physiology 298, 407–414.CrossRefGoogle ScholarPubMed
Anil, M. H. & Forbes, J. M. (1984). Selective liver denervation and feeding behaviour of sheep. Canadian Journal of Animal Science 64, 343–344.CrossRefGoogle Scholar
Anil, M. H. & Forbes, J. M. (1988). The roles of hepatic nerves in the reduction of food intake as a consequence of intraportal sodium propionate administration in the sheep. Quarterly Journal of Experimental Phjviology 73, 539–546.Google ScholarPubMed
Ash, R. & Baird, G. D. (1973). Activation of volatile fatty acids in bovine liver and rumen epithelium. Evidence for control by autoregulation. Biocheniical Journal 136, 311–319.Google ScholarPubMed
Baertschi, A. J. & Vallet, P. G. (1981). Osmosensitivity of the hepatic portal vein area and vasopressin release in rats. Journal of Physiology 315, 217–230.CrossRefGoogle ScholarPubMed
Baile, C. A. & Forbes, J. M. (1974). Control of feed intake and regulation of energy balance in ruminants. Physiological Reviews 54, 160–214.CrossRefGoogle ScholarPubMed
Bellinger, L. L. (1981). Commentary on ‘the current status of the hepatostatic theory of food intake control’. Appetite 2, 144–145.CrossRefGoogle ScholarPubMed
Bergman, E. N. (1990). Energy contributions of volatile fatty acids from the gastrointestinal tract in various species. Physiological Reviews 70, 567–590.CrossRefGoogle ScholarPubMed
Bergman, E. N., Roe, W. E. & Kon, K. (1966). Quantitative aspects of propionate metabolism and gluconeogenesis in sheep. American Journal of Physiology 211, 793–799.CrossRefGoogle ScholarPubMed
Burrin, D. G., Ferrell, C. L., Britton, R. A. & Bauer, M. (1990). Level of nutrition and visceral organ size and metabolic activity in sheep. British Journal of Nutrition 64, 439–448.CrossRefGoogle ScholarPubMed
Burrin, D. G., Ferrell, C. L., Eisemann, J. H., Britton, R. A. & Nienaber, J. A. (1989). Effect of level of nutrition on splanchnic blood flow and oxygen consumption in sheep. British Journal of Nutrition 62, 23–34.Google ScholarPubMed
De Jong, A. (1981). Short- and long-term effects of eating on blood composition in free-feeding goats. Journal of Agricultural Science, Cambridge 96, 659–668.CrossRefGoogle Scholar
De Jong, A., Steffens, A. B. & De Ruiter, L. (1981). Effects of portal volatile Fatty acid infusions on meal patterns and blood composition in goats. Physiology and Behavior 27, 683–689.CrossRefGoogle ScholarPubMed
Demigné, C., Yacoub, C., Morand, C. & Rémésy, C. (1991). Interactions between propionate and amino acid metabolism in isolated sheep hepatocytes. British Journal of Nutrition 65, 301–317.CrossRefGoogle ScholarPubMed
Farningham, D. A. H. (1990). Effect of hepatic portal infusion of propionate or equivalent saline loads on food intake in sheep. Proceedings of the Nutrition Society 49, 221A.Google Scholar
Farningham, D. A. H. (1991). Synergism between cholecystokinin octapeptide and propionate in the control of food intake in ruminants. Regulatory Peptides 35, 236.CrossRefGoogle Scholar
Grovum, W. L. & Bignell, W. W. (1989). Results refuting volatile fatty acids per se as signals of satiety in ruminants. Proceedings of the Nutrition Society 48, 3A.Google Scholar
Hungate, R. E. (1966). The Rumen and its Microbes, 1st ed. New York and London: Academic Press.Google Scholar
Koopmans, H. S. (1984). Hepatic control of food intake. Appetite 5, 127–131.CrossRefGoogle ScholarPubMed
Niijima, A. (1982). Glucose-sensitive afferent nerve fibres in the hepatic branch of the vagus nerve in the guinea-pig. Journal of Physiology 332, 315–323.CrossRefGoogle ScholarPubMed
Niijima, A. (1983). Glucose-sensitive afferent nerve fibers in the liver and their role in food intake and blood glucose regulation. Journal of the Autonomic Nervous System 9, 207–220.CrossRefGoogle ScholarPubMed
Novin, D., Robinson, K., Culbreth, L. A. & Tordoff, M. G. (1985). Is there a role for the liver in the control of food intake? American Journal of Clinical Nutrition 42, 1050–1062.Google Scholar
Novin, D., Sanderson, J. D. & Vanderweele, D. A. (1974). The effect of isotonic glucose on eating as a function of feeding condition and infusion site. Physiology and Behavior 13, 3–7.CrossRefGoogle ScholarPubMed
Quigley, J. D. & Heitmann, R. N. (1991). Effects of propionate infusion and dietary energy on dry matter intake in sheep. Journal of Animal Science 69, 1178–1187.CrossRefGoogle ScholarPubMed
Russek, M. (1963). Participation of hepatic glucoreceptors in the control of food intake. Nature 197, 79–80.CrossRefGoogle Scholar
Russek, M. (1981). Current status of the hepatostatic theory of food intake control. Appetite 2, 137–143.CrossRefGoogle ScholarPubMed
Tordoff, M. G., Tluczek, J. P. & Friedman, M. I. (1989). Effect of hepatic portal glucose concentration on food intake and metabolism. American Journal of Physiology 257, R1474 R1480.Google ScholarPubMed
Trinder, P. (1969). Determination of glucose in blood using glucose oxidase with an alternative oxygen acceptor. Annals of Clinical Biochemistry 6, 24–27.CrossRefGoogle Scholar
Weekes, T. E. C. & Webster, A. J. F. (1975). Metabolism of propionate in the tissues of the sheep gut. British Journal of Nutrition 33, 425–438.CrossRefGoogle Scholar