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The role of meat in the expression of rheumatoid arthritis

Published online by Cambridge University Press:  09 March 2007

William B. Grant
William B. Grant
Affiliation:
12 Sir Francis Wyatt Place, Newport News, VA 23606-3660, USA
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Abstract

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Rheumatoid arthritis (RA) is characterized by inflammation of the synovial tissues in the joints. A number of papers related to dietary components that are associated with this inflammation are reviewed. In addition, the ecological approach is used to study the links between diet and RA. Multi-country data for prevalence of RA for females from eight and fifteen countries were compared statistically with components of national dietary supply. Fat from meat and offal for the period 2 years before the prevalence data was found to have the highest statistical association with the prevalence of RA (r2 0·877, P<0·001 for eight countries). The statistical correlations for meat and offal were almost as high as those for their fat. Similar correlations were found for temporal changes in indices of effects of RA in several European countries between 1968 and 1978 as more meat was added to the national diets, although the correlations were higher for meat than for fat. It is hypothesized that meat and offal may be a major factor contributing to the inflammation in RA. In the present short review, the author examines some of the data that associate meat consumption with RA and the possible factors, e.g. fat, Fe and nitrite, which may contribute to the inflammation.

Keywords

DietFatMeatOxidative stressRheumatoid arthritis
Type
Review article
Information
British Journal of Nutrition , Volume 84 , Issue 5 , November 2000 , pp. 589 - 595
Copyright
Copyright © The Nutrition Society 2000

References

Ahoiid, K, Heliovaara, M, Sievers, K, Maatela, J and Isomaki, H (1989) Clinical arthritis associated with positive radiological and serological findings in Finnish adults. Rheumatism International 9, 7–11.Google Scholar
Armstrong, B and Doll, R (1975) Environmental factors and cancer incidence and mortality in different countries, with special reference to dietary practices. International Journal of Cancer 15, 617–631.CrossRefGoogle ScholarPubMed
Arnett, FC, Edworthy, SM, Bloch, DA, McShane, DJ, Fries, JF and Cooper, NS (1988) The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheumatism 31, 315–324.CrossRefGoogle ScholarPubMed
Beasley, RP, Bennett, PH and Chun Lin, C (1983) Low prevalence of rheumatoid arthritis in Chinese. Prevalence survey in a rural community. Journal of Rheumatology 10 (Suppl.), 11–15.Google Scholar
Behrend, T, Lawrence, JS, Behrend, H and Fischer, K (1972) Prevalence of rheumatoid arthritis in rural Germany. International Journal of Epidemiology 1, 153–156.CrossRefGoogle ScholarPubMed
Belch, JJF and Hill, A (2000) Evening primrose oil and borage oil in rheumatologic conditions. American Journal of Clinical Nutrition 71 (Suppl.), 352S–356S.CrossRefGoogle ScholarPubMed
Blake, DR, Gallagher, PJ, Potter, AR, Bell, MJ and Bacon, PA (1984) The effect of synovial iron on the progression of rheumatoid disease. A histologic assessment of patients with early rheumatoid synovitis. Arthritis and Rheumatism 27, 495–501.CrossRefGoogle ScholarPubMed
Buchanan, A and Laurent, RM (1990) Rheumatoid arthritis: an example of ecological succession. Canadian Bulletin of Medical History 7, 77–91.Google ScholarPubMed
Chou, CT, Uksila, J and Toivanen, P (1998) Enterobacterial antibodies in Chinese patients with rheumatoid arthritis and ankylosing spondylitis. Clinical Experimental Rheumatology 16, 161–164.Google ScholarPubMed
Cleland, LG (1991) Diet and arthritis. Current Therapeutics 32, 51–56.Google Scholar
Cleland, LG and James, MJ (1997) Rheumatoid arthritis and the balance of dietary. n-6 and. n-3 essential fatty acids. British Journal of Rheumatology 36, 513–515.CrossRefGoogle ScholarPubMed
Darlington, LG and Gamlin, L (1996) In Diet and Arthritis. London: Vermilion.Google Scholar
Darlington, LG, Ramsey, NW and Mansfield, JR (1986) Placebo-controlled, blind study of dietary manipulation therapy in rheumatoid arthritis. Lancet i, 236–238.CrossRefGoogle Scholar
Darmawan, J; (1988) Rheumatic conditions in the northern part of central Java. An epidemiological survey Ph.D Thesis.Google Scholar
DeLuca, P, Rothman, D and Zurier, RB (1995) Marine and botanical lipids as immunomodulatory and therapeutic agents in the treatment of rheumatoid arthritis. Rheumatic Disease Clinics of North America 21, 759–777.CrossRefGoogle ScholarPubMed
den Oudsten, SA, Planten, O, Posthuyma, EPS, (1968) Longitudinal survey of RA in an urban district of Rotterdam. In Population Studies of the Rheumatic Diseases, vol. 15, 99–105M. [Bennett, PH and Wood, PHN, editors]. Amsterdam: Excerpta Medica.Google Scholar
Dich, J, Jarvinen, R, Knekt, P and Penttila, PL (1996) Dietary intakes of nitrate, nitrite and NDMA the Finnish Mobile Clinic Health Examination Survey. Food Additives and Contaminants 13, 541–552.CrossRefGoogle ScholarPubMed
Enders, S and Von Schacky, C (1996) n-3 Polyunsaturated fatty acids and human cytokine synthesis. Current Opinion in Lipidology 7, 48–52.CrossRefGoogle Scholar
Engel, A, (1968) Rheumatoid arthritis in US adults. In Population Studies of the Rheumatic Diseases, p. 83 [Bennett, PH and Wood, PHN, editors]. Amsterdam: Excerpta Medica.Google Scholar
Erasmus, U (1993) In Fats That Heal, Fats That Kill. Burnaby,BC: Alive Books.Google Scholar
Farrell, AJ, Blake, DR, Palmer, RMJ and Moncada, S (1992) Increased concentrations of nitrite in synovial fluid and serum samples suggest increased nitric oxide synthesis in rheumatic diseases. Annals of the Rheumatic Diseases 51, 1219–1222.CrossRefGoogle ScholarPubMed
Fernandes, G and Jolly, CA (1998) Nutrition and autoimmune disease. Nutrition Reviews 56, S161–S169.CrossRefGoogle ScholarPubMed
Feskanich, D, Willett, WC, Stampfer, JJ and Colditz, GA (1997) Milk, dietary calcium, and bone fractures in women: a 12-year prospective study. American Journal of Public Health 87, 992–997.CrossRefGoogle ScholarPubMed
Food and Agriculture Organization (1991) Food Balance Sheets. Rome: FAO.Google Scholar
Fox, DA (1997) Rheumatoid arthritis – heresies and speculations. Perspectives in Biology and Medicine 40, 479–491.CrossRefGoogle ScholarPubMed
Garrett, SL, Kennedy, LG and Calin, A (1993) Patient's perceptions of disease modulation by diet in inflammatory (rheumatoid arthritis/ankylosing spondylitis) and degenerative arthropathies. British Journal of Rheumatology 32 (Suppl. 2), 43.Google Scholar
Giovannucci, E (1999) Tomatoes, tomato-based products, lycopene, and cancer: Review of the epidemiologic literature. Journal of the National Cancer Institute 91, 317–331.CrossRefGoogle ScholarPubMed
Giovannucci, E, Rimm, EB, Wolk, A, Ascherio, A, Stampfer, MJ, Colditz, GA and Willett, WC (1998) Calcium and fructose intake in relation to risk of prostate cancer. Cancer Research 58, 442–447.Google ScholarPubMed
Grant, WB (1997) Dietary links to Alzheimer's disease. Alzheimer's Disease Review 2, 42–55.Google Scholar
Grant, WB (1998) The role of milk and sugar in heart disease. American Journal of Natural Medicine 5, 19–23.Google Scholar
Grant, WB (1999) Dietary links to Alzheimer's disease: 1999 update. Journal of Alzheimer's Disease 1, 197–201.CrossRefGoogle ScholarPubMed
Grant, WB (1999) Dietary fiber and colorectal cancer. The Townsend Letter for Doctors and Patients 192, 112–113.Google Scholar
Grant, WB (1999) An ecologic study of dietary links to prostate cancer. Alternative Medicine Review 4, 162–169.Google ScholarPubMed
Grant, WB (1999) Lactose maldigestion and calcium from dairy products. American Journal of Clinical Nutrition 70, 301–302.CrossRefGoogle ScholarPubMed
Haavik, T (1979) Rheumatoid arthritis in a Norwegian county. A study based on the local doctor's files. Scandinavian Journal of Rheumatology 8, 184–186.CrossRefGoogle Scholar
Hansen, G, Nielson, L, Kluger, E, Thysen, MH, Emmertsen, H, Stengard-Pedersen, K, Lund, EC, Unger, B and Andersen, PW (1998) Nutritional status of Danish patients with rheumatoid arthritis and effects of a diet adjusted in energy intake, fish content and antioxidants (in Danish). Ugeskr Laeger 160, 3074–3078.Google ScholarPubMed
Heliövaara, M, Knekt, P, Aho, K, Aaran, R-K, Alfthan, G and Aromaa, A (1994) Serum antioxidants and risk of rheumatoid arthritis. Annals of Rheumatic Diseases 53, 51–53.CrossRefGoogle ScholarPubMed
Hellgren, L (1970) Prevalence of rheumatoid arthritis in different geographical areas of Sweden. Acta Rheumatologica Scandinavica 16, 293–303.CrossRefGoogle ScholarPubMed
Henderson, CJ and Panush, RS (1999) Diets, dietary supplements, and nutritional therapies in rheumatic diseases. Rheumatic Disease Clinics of North America 25, 937–968.CrossRefGoogle ScholarPubMed
James, MJ and Cleland, LG (1997) Dietary. n-3 fatty acids and therapy for rheumatoid arthritis. Seminars in Arthritis and Rheumatism 27, 85–97.CrossRefGoogle ScholarPubMed
James, MJ, Gibson, RA and Cleland, LG (2000) Dietary polyunsaturated fatty acids and inflammatory mediator production. American Journal of Clinical Nutrition 71 (Suppl.), 343S–348S.CrossRefGoogle ScholarPubMed
Kato, H, Duff, IF, Russell, WJ, Uda, Y, Hamilton, HB, Kawamoto, S and Johnson, KG (1971) Rheumatoid arthritis and gout in Hiroshima and Nagasaki Japan. A prevalence and incidence study. Journal of Chronic Disease 23, 659–679.CrossRefGoogle ScholarPubMed
Kavanagh, R, Workman, E, Nash, P, Smith, M, Hazleman, BL and Hunter, JO (1995) The effects of elemental diet and subsequent food reintroduction on rheumatoid arthritis. British Journal of Rheumatism 34, 270–273.CrossRefGoogle Scholar
Kjeldsen-Kragh, J (1999) Rheumatoid arthritis treated with vegetarian diets. American Journal of Clinical Nutrition 70, 594S–600S.CrossRefGoogle ScholarPubMed
Kjeldsen-Kragh, J, Haugen, M, Borchgrevink, CF and Førre, Ø (1994) Vegetarian diet for patients with rheumatoid arthritis – status: two years after introduction of the diet. Clinical Rheumatology 13, 475–482.CrossRefGoogle ScholarPubMed
Kjeldsen-Kragh, J, Haugen, M, Borchgrevink, CF, Laerum, E, Eek, M, Mowinkel, P, Hovi, K and Førre, Ø (1991) Controlled trial of fasting and one-year vegetarian diet in rheumatoid arthritis. Lancet 338, 899–902.CrossRefGoogle ScholarPubMed
Kremer, JM (1996) Effects of modulation of inflammatory and immune parameters in patient with rheumatic and inflammatory disease receiving dietary supplementation of. n-3 and. n-6 fatty acids. Lipids 31, S243–S247.CrossRefGoogle ScholarPubMed
Kremer, JM (2000) N-3 Fatty acid supplements in rheumatoid arthritis. American Journal of Clinical Nutrition 71 (Suppl.), 349S–351S.CrossRefGoogle ScholarPubMed
Lawrence, JS (1961) Prevalence of rheumatoid arthritis. Annals of the Rheumatic Diseases 20, 11–17.CrossRefGoogle ScholarPubMed
Lauer, K (1991) The history of nitrite in human nutrition: a contribution from German cookery books. Journal of Clinical Epidemiology 44, 261–264.CrossRefGoogle ScholarPubMed
Lee, K, Greger, JL, Consaul, JR, Graham, KL and Chinn, MS (1986) Nitrate, nitrite balance, and de novo synthesis of nitrate in human consuming cured meats. American Journal of Clinical Nutrition 44, 188–194.CrossRefGoogle ScholarPubMed
Leistner, K, Wessel, G and Allander, E (1986) Medium-term trends in the occurrence of rheumatic diseases in European countries. Scandinavian Journal of Rheumatology 15, 206–218.CrossRefGoogle ScholarPubMed
Linos, A, Worthington, JW, O'Fallon, WM and Kurland, LT (1980) The epidemiology of rheumatoid arthritis in Rochester Minnesota: a study of incidence, prevalence, and mortality. American Journal of Epidemiology 111, 87–98.CrossRefGoogle ScholarPubMed
McMillan, RM, Foster, SJ, Shaw, JS, (1995) Approaches to novel anti-arthritic drugs by modulation of the arachidonic acid cascade. In Mechanisms and Models in Rheumatoid Arthritis, pp. 283-300 [Henderson, B, Edwards, JCW and Pettipher, ER, editors]. London: Academic Press.CrossRefGoogle Scholar
Mapp, PI, Grootveld, MC and Blake, DR (1995) Hypoxia, oxidative stress and rheumatoid arthritis. British Medical Bulletin 51, 419–436.CrossRefGoogle ScholarPubMed
Moolenburgh, JD, Valkenburg, HA and Fourie, PB (1986) A population study on rheumatoid arthritis in Lesotho, southern Africa. Annals of the Rheumatic Diseases 45, 691–695.CrossRefGoogle Scholar
Nenonen, FT, Helve, TA, Tauma, A-L and Hänninen, OO (1998) Uncooked, lactobacilli-rich, vegan food and rheumatoid arthritis. British Journal of Rheumatology 37, 274–281.CrossRefGoogle ScholarPubMed
Panush, RS (1997) Diet therapy and other questionable remedies for arthritis. In Arthritis and Allied Conditions. A Textbook of Rheumatology 13th ed., pp. 857-870 [Koopman, WJ, editors]. Baltimore, MD: Williams and Wilkins.Google Scholar
Panush, RS, Stroud, RM and Webster, EM (1986) Food-induced (allergic) arthritis. Inflammatory arthritis exacerbated by milk. Arthritis and Rheumatism 29, 220–226.CrossRefGoogle ScholarPubMed
Prior, IAM, Evans, JG, Morrison, RBI and Rose, BS (1970) The carteron study: six patterns of vascular, respiratory, rheumatic and related abnormalities in a sample of New Zealand European adults. New Zealand Medical Journal 72, 169–177.Google Scholar
Roberts, C and Manchester, K (1997) In The Archaeology of Disease, 2nd ed., pp. 116-118, Ithaca, NY: Cornell University Press.Google Scholar
Sasaki, S, Horacsek, M and Kestellot, H (1993) An ecological study of the relationship between dietary fat intake and breast cancer mortality. Preventive Medicine 22, 187–202.CrossRefGoogle ScholarPubMed
Shapiro, JA, Koepsell, TD, Voigt, LF, Dugowson, CE, Kestin, M and Nelson, JL (1996) Diet and rheumatoid arthritis in women: a possible protective effect of fish consumption. Epidemiology 7, 256–263.CrossRefGoogle ScholarPubMed
Silman, AJ and Hochberg, MC (1993) In Epidemiology of the Rheumatic Diseases, pp. 7-68. Oxford: Oxford University Press.CrossRefGoogle Scholar
Sitaj, S, Sebo, M, (1968) Rheumatoid arthritis and ankylosing spondylitis in Czechoslovakia. In Population Studies of the Rheumatic Diseases, pp. 64-68 [Bennettand, PHWood, PHN, editors]. Amsterdam: Excerpta Medica.Google Scholar
Sköldstam, L (1986) Fasting and vegan diet in rheumatoid arthritis. Scandinavian Journal of Rheumatology 15, 219–223.CrossRefGoogle ScholarPubMed
Smith, MA, Petot, GJ and Perry, G (1997) Diet and oxidative stress: a novel synthesis of epidemiological data on Alzheimer's disease. Alzheimer's Disease Review 2, 58–59.Google Scholar
Sorensen, K (1973) Rheumatoid arthritis in Denmark: two population studies. Danish Medical Bulletin 20, 86–93.Google ScholarPubMed
Tzonchev, VT, Pilossoff, T, Kanev, K, (1968) Prevalence of inflammatory arthritis in Bulgaria. In Population Studies of the Rheumatic Diseases, p. 363 [Bennett, PH and Wood, PHN, editors]. Amsterdam: Excerpta Medica.Google Scholar
Wigand, R, Meyer, J, Busse, R and Hecker, M (1997) Increased serum. N G-hydrocy-L-arginine in patients with rheumatoid arthritis and systemic lupus erythematosus as an index of an increased nitric oxide synthase activity. Annals of the Rheumatic Diseases 56, 330–332.CrossRefGoogle ScholarPubMed