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The response of serum 25-hydroxyvitamin D concentrations to vitamin D intake and insolation in sheep

Published online by Cambridge University Press:  09 March 2007

B. S. W. Smith  and
H. Wright
B. S. W. Smith
Affiliation:
Moredun Research Institute, Edinburgh EHI7 7JH
H. Wright
Affiliation:
Moredun Research Institute, Edinburgh EHI7 7JH
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Abstract

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1. Vitamin D-depleted, housed sheep were given diets providing fixed intakes of cholecalciferol ranging from 0.0 to 0.8 μg/kg body-wt per d for 220 d. Thereafter they were shorn, deprived of dietary cholecalciferol and turned out from 30 June to 30 November. The concentration of 25-hydroxyvitamin D (25-OHD) in serum was determined at frequent intervals.

2. The serum concentrations of 25-OHD took approximately 10 weeks to stabilize after which they reflected dietary intake over the range 0.1–0.4 μg/kg body-wt per d. For intakes of 0.4 and 0.8 μg/kg body-wt per d the mean maximum concentrations were similar, but the rates of increase differed. The latter was proportional to the logarithm of intake over the range studied.

3. Changes in serum 25-OHD due to insolation were similar in all sheep regardless of their starting values, and consequently in some animals reached levels considerably greater than from the dietary source.

4. Although the response of serum 25-OHD to the higher dietary intakes appeared to be limited there was no evidence of any such control over the response to endogenously-synthesized vitamin.

Type
Papers on General Nutrition
Information
British Journal of Nutrition , Volume 43 , Issue 3 , May 1980 , pp. 533 - 540
Copyright
Copyright © The Nutrition Society 1980

References

REFERENCES

Agricultural Research Council (1965). The Nutrient Requirements of Farm Livestock No. 2, Ruminants. London: Agricultural Research Council.Google Scholar
Andrews, E. D. & Cunningham, I. J. (1945). N.Z. J. Sci. Tech. 27, 225.Google Scholar
Beadle, P. C. (1977). Photochem. Photobiol. 25, 519.CrossRefGoogle Scholar
Belsey, R. E., De Luca, H. F. & Potts, J. T. Jr (1974). J. clin. Endocr. Metab. 38, 1046.CrossRefGoogle Scholar
Bhattacharyya, M. H. & De Luca, H. F. (1973). J. biol. Chem. 218, 2969.CrossRefGoogle Scholar
Clark, M. B. & Potts, J. T. Jr (1977). Calc. Tiss. Res. 22, 29.CrossRefGoogle Scholar
Clegg, F. G. (1976). Vet. Rec. 98, 144.CrossRefGoogle Scholar
Counts, S. J., Baylink, D. J., Shen, F. & Sherrard, D. J. (1975). Ann. intern. Med. 82, 196.CrossRefGoogle Scholar
Dalgarno, A. C., Hill, R. & McDonald, I. (1962). Br. J. Nutr. 16, 91.CrossRefGoogle Scholar
Fiske, C. A. & Subbarow, Y. (1925). J. biol. Chem. 66, 375.CrossRefGoogle Scholar
Fox, B. W. (1974). In Liquid Scintillation Counting, vol. 3, p. 202 [Crook, M. A. and Johnson, P., editors]. London: Heyden.Google Scholar
Fraser, D. R. (1975). Proc. Nutr. Soc. 34, 139.CrossRefGoogle Scholar
Eaddad, J. G. & Stamp, T. C. B. (1974). Am. J. Med. 57, 57.Google Scholar
Holick, M. F. & De Luca, H. F. (1978). In Vitamin D, p. 51 [Lawson, D. E. M., editor], London: Academic Press.Google ScholarPubMed
Hughes, M. R., Baylink, D. J., Jones, P. G. & Haussler, M. R. (1976). J. clin. Invest. 58, 61.CrossRefGoogle Scholar
Mawer, E. B., Backhouse, J., Holman, C. A., Lumb, G. A. & Stanbury, S. W. (1972). Clin. Sci. 43, 413.CrossRefGoogle Scholar
Mawer, E. G. & Reeve, A. (1977). Calc. Tiss. Res. 22, 24.CrossRefGoogle Scholar
Morrisey, R. L., Cohn, R. M., Empson, R. N. Jr, Greene, H. L., Taunton, O. D. & Ziporin, Z. Z. (1977). J. Nutr. 107, 1027.CrossRefGoogle Scholar
Offerman, G. & Dittman, F. (1974). Horrn. Metab. Rcs. 6, 534.CrossRefGoogle Scholar
Quarterman, J., Dalgarno, A. C. & Adam, A. (1964). Br. J. Nutr. 18, 79.CrossRefGoogle Scholar
Quarterman, J., Dalgarno, A. C. & McDonald, I. (1961). Proc. Nutr. Soc. 20, xxviii.Google Scholar
Rodbard, D. & Lewald, J. E. (1970). Acta endocr., Copenh. 147, 79 (Suppl.).Google Scholar
Stamp, T. C. B., Haddad, J. G. & Twigg, C. A. (1977). Lancet i, 1341.CrossRefGoogle Scholar
Stanbury, S. W. & Mawer, E. B. (1978). In Vitamin D, p. 303 [Lawson, D. E. M., editor]. London: Academic Press.Google ScholarPubMed
Stanbury, S. W., Mawer, E. B., Lumb, G. A., Hill, L. F., Holman, C. A., Taylor, C. M. & Torkington, P. (1973). In Clinical Aspects of Metabolic Bone Disease, p. 562 [Frame, B. and Duncan, H., editors]. Amsterdam: Excerpta Media.Google Scholar
Taylor, C. M., de Silva, P. & Hughes, S. E. (1977). Calc. Tin. Rex 22, 40.CrossRefGoogle Scholar
Taylor, C. M., Hughes, S. E. & de Silva, P. (1976). Biochem. biophys. Res. Commun. 70, 1243.CrossRefGoogle Scholar
Tucker, G., Gagnon, R. E. & Haussler, M. R. (1973). Archs Biochem. Biophys. 155, 47.CrossRefGoogle Scholar