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Replacement of linoleic acid with α-linolenic acid does not alter blood lipids in normolipidaemic men

Published online by Cambridge University Press:  09 March 2007

D. Pang ,
M. A. Allman-Farinelli ,
T. Wong ,
R. Barnes  and
K. M. Kingham
D. Pang
Affiliation:
Human Nutrition Unit, Department of Biochemistry, University of Sydney, NSW 2006, Australia
M. A. Allman-Farinelli*
Affiliation:
Human Nutrition Unit, Department of Biochemistry, University of Sydney, NSW 2006, Australia
T. Wong
Affiliation:
Human Nutrition Unit, Department of Biochemistry, University of Sydney, NSW 2006, Australia
R. Barnes
Affiliation:
Human Nutrition Unit, Department of Biochemistry, University of Sydney, NSW 2006, Australia
K. M. Kingham
Affiliation:
Human Nutrition Unit, Department of Biochemistry, University of Sydney, NSW 2006, Australia
*
*Corresponding author: Dr M. A. Allman-Farinelli, fax +61 2 9351 6022, email [email protected]
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Abstract

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The effect of partial dietary replacement of linoleic acid (18:2n-6; linoleic acid-rich diet) with α-linolenic acid (18:3n-3; α-linolenic acid-rich diet) on plasma lipids was investigated in twenty-nine healthy young men. After a 2-week stabilization period subjects were randomly assigned to either the α-linolenic acid-rich diet group (n 15), receiving a mean of 10.1 g of α-linolenic acid and 12.1 g of linoleic acid/d, or the linoleic acid-rich diet group (n 14), receiving a mean of 1.0 g of α-linolenic acid and 21.0 g of linoleic acid/d, for a 6-week test period. Blood samples were taken at the commencement of the stabilization period and at the start (week 0), midpoint (week 3) and endpoint (week 6) of the test period and plasma lipids analysed. The changes occurring on the linoleic acid-rich diet and α-linolenic acid-rich diet were compared but no significant differences in the changes in plasma total cholesterol, LDL-cholesterol, HDL-cholesterol, the subfractions HDL2 and HDL3 or triacylglycerols were found. These results indicate that dietary replacement of linoleic acid with α-linolenic acid in the diet of healthy male subjects offers similar cardioprotective benefits with respect to lipid metabolism.

Keywords

Linolenic acidLinoleic acidBlood lipidsLinseed oil
Type
Research Article
Information
British Journal of Nutrition , Volume 80 , Issue 2 , February 1998 , pp. 163 - 167
Copyright
Copyright © The Nutrition Society 1998

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