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The relationship between hormonal balance and growth in malnourished children and rats

Published online by Cambridge University Press:  08 December 2008

P. G. Lunn ,
R. G. Whitehead ,
T. J. Cole  and
S. Austin
P. G. Lunn
Affiliation:
Dunn Nutrition Unit, University of Cambridge, and Medical Research Council, Milton Road, Cambridge CB4 1XJ
R. G. Whitehead
Affiliation:
Dunn Nutrition Unit, University of Cambridge, and Medical Research Council, Milton Road, Cambridge CB4 1XJ
T. J. Cole
Affiliation:
Dunn Nutrition Unit, University of Cambridge, and Medical Research Council, Milton Road, Cambridge CB4 1XJ
S. Austin
Affiliation:
Dunn Nutrition Unit, University of Cambridge, and Medical Research Council, Milton Road, Cambridge CB4 1XJ
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Abstract

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1. Plasma concentrations of insulin, cortisol and growth hormone, and growth velocities have been measured in a group of Gambian village children up to 3 years of age. All three hormones showed changes in concentration with age, as did rates of growth.

2. Plasma insulin concentrations in the children were directly correlated with velocity of growth in height and weight, whereas cortisol concentrations showed inverse relationships. The values for insulin:cortisol concentration correlated more closely with growth velocity than did either hormone individually. Growth hormone values in plasma exhibited only marginal correlations with growth in height or weight, and these were negative.

3. Similar relationships between these hormones and growth were obtained from an animal experiment in which the rates of growth of rats were altered by restricting dietary intake of protein or energy or both.

4. Possible mechanisms for these observations are discussed in the light of recent knowledge concerning the hormonal control of growth rates.

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 41 , Issue 1 , January 1979 , pp. 73 - 84
Copyright
Copyright © The Nutrition Society 1979

References

Brasel, J. A. (1973). In Endocrine Aspects of Malnutrition. Kroc Foundation Symposia No. 1, p. 115 (Gardner, L. I. and Amacher, P., editors). California: Kroc Foundation.Google Scholar
Catt, K. J. (1970 a). Lancet i, 1273.Google Scholar
Catt, K. J. (1970 b). Lancet ii, 353.Google Scholar
Cheek, P. B. (1972). In Human Growth, p. 337 (Cheek, P. B., editor). Philadelphia: Lea and Febiger.Google Scholar
Coward, W. A., Whitehead, R. G. & Lunn, P. G. (1977). Br. J. Nutr. 38, 115.CrossRefGoogle Scholar
Daughaday, W. J., Phillips, L. S. & Mueller, M. C. (1976). Endocrinology 98, 1214.CrossRefGoogle Scholar
Elders, M. J., Wingfield, B. S., McNatt, M. L., Lee, J. A. & Hughes, E. R. (1975). Am. J. dis. Childh. 129, 1393.CrossRefGoogle Scholar
Froesch, E. R., Zapf, J., Audhya, T. K., Ben Porath, E., Segen, J. B. & Gibson, K. D. (1976). Proc. Natn. Acad. Sci. U.S.A. 73, 1904.Google Scholar
Goldberg, A. L. & Goldspink, D. F. (1975). Am. J. Physiol. 228, 310.CrossRefGoogle Scholar
Grant, D. B., Hambley, J., Becker, D. & Pimstone, B. L. (1973). Archs dis. Childh. 48, 596.CrossRefGoogle Scholar
Hales, C. N. & Randle, P. J. (1963). Biochem. J. 88, 137.CrossRefGoogle Scholar
Hall, K. (1972). Acta endocr. Suppl. 163, 1053.Google Scholar
Jelliffe, D. B. (1966). Wld Hlth. Orgn. Monogr. Ser. no. 53, p. 271.Google Scholar
Krieger, I. (1973). In Endocrine Aspects of Malnutririon. Kroc Foundation Symposia No. 1, p. 129 (Gardner, L. I. and Amacher, P., editors). California: Kroc Foundation.Google Scholar
Laron, Z., Karp, M., Pertzelan, A. & Kauli, R. (1972). Israel. J. med. Sci. 8, 440.Google Scholar
Laron, Z., Pertzelan, A. & Karp, M. (1968). Israel. J. med. Sci. 4, 883.Google Scholar
Loeb, J. N. (1976). New Engl. J. med. 295, 547.CrossRefGoogle Scholar
Lunn, P. G., Whitehead, R. G., Baker, B. A. & Austin, S. (1976). Br. J. Nutr. 36, 537.CrossRefGoogle Scholar
Lunn, P. G., Whitehead, R. G., Hay, R. W. & Baker, B. A. (1973). Br. J. Nutr. 29, 399.CrossRefGoogle Scholar
McGregor, I. A., Rahman, A. K., Thomson, A. M., Billewicz, W. Z. & Thompson, B. (1970). Trans. R. Soc. trop. Med. Hyg. 64, 48.CrossRefGoogle Scholar
Molinatti, G. M., Massara, F., Strumia, E., Pennisi, F., Scasellati, G. A. & Vancheri, L. (1969). J. nucl. Biol. Med. 13, 1.Google Scholar
Morris, H. G., Jørgensen, J. R. & Jenkins, S. A. (1968). J. clin. Invest. 47, 427.Google Scholar
Phillips, L. S., Herington, A. C. & Daughaday, W. H. (1973). Endocrinology 97, 780.CrossRefGoogle Scholar
Rappaport, R., Bouthreuil, E., Marti-Henneberg, C. & Basmaciogullari, A. (1973). Acta paed. Scand. 62, 513.CrossRefGoogle Scholar
Root, A. W., Bongiovanni, A. M. & Eberlein, R. (1969). J. Paediat. 75, 826.CrossRefGoogle Scholar
Rowland, M. G. M., Cole, T. J. & Whitehead, R. G. (1977). Br. J. Nutr. 37, 441.CrossRefGoogle Scholar
Stuart, H. C. & Stevenson, S. S. (1954). In Textbook of Pediatrics, 8th ed., p. 48 (Nelson, W. E., editor). Philadelphia: Saunders.Google Scholar
Van Wyk, J. J., Underwood, L. E., Baseman, J. B., Hinty, R. L., Clemmons, D. R. & Marshall, R. N. (1975). In Advances in Metabolic Disorders, vol. 8, p. 127 (Luft, R. & Hall, K., editors). New York, San Francisco, London: Academic Press.Google Scholar
Whitehead, R. G. (1976). Lancet ii, 1192.CrossRefGoogle Scholar
Whitehead, R. G., Coward, W. A., Lunn, P. G. & Rutishauser, I. H. E. (1977). Trans. Roy. Soc. trop. Med Hyg. 71, 189.CrossRefGoogle Scholar
Whitehead, R. G., Rowland, M. G. M., Hutton, M., Prentice, A. M., Müller, E. & Paul, A. (1978). Lancet ii, 178.CrossRefGoogle Scholar