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Relationship between dietary Na+ intake, aldosterone and colonic amiloride-sensitive Na+ transport

Published online by Cambridge University Press:  09 March 2007

J. Pácha  and
I. Pohlová
J. Pácha
Affiliation:
Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic
I. Pohlová
Affiliation:
Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic
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Abstract

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The effect of changes in dietary Na+ intake on plasma aldosterone levels and electrogenic amiloride-sensitive Na+ transport (Iamil) was studied in the rat distal colon. Five groups of rats were fed on diets containing different amounts of Na+. Estimated Na+ intake ranged from about 400–80000 ?equiv Na+ /kg body weight (BW) per d. Both variables investigated, Iamil and plasma aldosterone, depended non-linearly on Na+ intake. Reduction of the daily Na+ intake increased plasma aldosterone levels and if these levels reached the value 200 pg/ml or more then Iamil was induced. The corresponding Na+ intake was 1300 ?equiv Na+/kg BW per d. Iamil was not observed at lower aldosterone levels and higher Na+ intakes. Aldosterone infusion for 7 d produced similar changes in Iamil compared with dietary Na+-depleted animals and made the estimation of maximum transport capacity of Iamil possible. We conclude that Iamil operates only if Na+ intake decreases below minimal Na+ requirement in growing rats and that the maximum transport capacity of this pathway is reached only after very severe Na+ deprivation.

Keywords

SodiumAldosteroneColon
Type
Intake and transport of sodium
Information
British Journal of Nutrition , Volume 73 , Issue 4 , April 1995 , pp. 633 - 640
Copyright
Copyright © The Nutrition Society 1995

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