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Refection in rats fed on a sucrose-based, riboflavin-deficient diet

Published online by Cambridge University Press:  25 February 2008

A. M. Prentice  and
C. J. Bates
A. M. Prentice
Affiliation:
Dunn Nutrition Unit, University of Cambridge and Medical Research Council, Cambridge
C. J. Bates
Affiliation:
Dunn Nutrition Unit, University of Cambridge and Medical Research Council, Cambridge
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Abstract

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1. Refection, resulting in an increased supply of riboflavin to riboflavin-deficient rats through coprophagy, was demonstrated on a sucrose-based diet when sensitive biochemical tests of riboflavin status were employed: these included measurements of NAD(P)H2:glutathione oxidoreductase (EC 1.6.4.2); succinate:(acceptor) oxidoreductase (EC 1.3.99.1) and NADH:(acceptor) oxidoreductase (EC 1.6.99.3).

2. The use of tail-cups to eliminate coprophagy, and hence refection, resulted in a more rapid and reproducible progress into severe deficiency.

3. The occurrence of refection on a sucrose-based diet may account for hitherto unexplained differences between previous publications on the biochemical effects of riboflavin deficiency.

Type
Papers on General Nutrition
Information
British Journal of Nutrition , Volume 43 , Issue 1 , January 1980 , pp. 171 - 177
Copyright
Copyright © The Nutrition Society 1980

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