Hostname: page-component-586b7cd67f-2plfb Total loading time: 0 Render date: 2024-11-20T12:20:05.988Z Has data issue: false hasContentIssue false
  • English
  • Français

Rapid chylomicron appearance following sequential meals: effects of second meal composition

Published online by Cambridge University Press:  09 March 2007

Kevin Evans ,
Pertti J. Kuusela ,
Martha L. Cruz ,
Ingrid Wilhelmova ,
Barbara A. Fielding  and
Keith N. Frayn
Kevin Evans
Affiliation:
Nuffield Department of Clinical Biochemistry, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK
Pertti J. Kuusela
Affiliation:
Oxford Lipid Metabolism Group, Nuffield Department of Clinical Medicine, Radcliffe Infirmary, Oxford OX2 6HE, UK
Martha L. Cruz
Affiliation:
Oxford Lipid Metabolism Group, Nuffield Department of Clinical Medicine, Radcliffe Infirmary, Oxford OX2 6HE, UK
Ingrid Wilhelmova
Affiliation:
Oxford Lipid Metabolism Group, Nuffield Department of Clinical Medicine, Radcliffe Infirmary, Oxford OX2 6HE, UK
Barbara A. Fielding
Affiliation:
Oxford Lipid Metabolism Group, Nuffield Department of Clinical Medicine, Radcliffe Infirmary, Oxford OX2 6HE, UK
Keith N. Frayn*
Affiliation:
Oxford Lipid Metabolism Group, Nuffield Department of Clinical Medicine, Radcliffe Infirmary, Oxford OX2 6HE, UK
*
*Corresponding author: Dr Keith N. Frayn: fax +44(0)1865 224652, email [email protected]
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Previous studies have noted the presence of an early postprandial peak in plasma triacylglycerol concentrations following successive fat-rich meals. An earlier study has shown that the triacylglycerol in this early peak originates from a previous meal. The present study was performed to investigate the effects of different second meals on the plasma triacylglycerol response. Six healthy subjects were studied on four occasions each. At 5 h following a fat-rich breakfast they ingested one of the following in a balanced design: a fat-rich meal, a low-fat meal, water or nothing by mouth. Blood samples were taken for 2.5 h following the second meal. An early peak in chylomicron and plasma triacylglycerol concentrations was seen following both low-fat and fat-rich second meals but not following water. During studies investigating postprandial lipaemia, further meals must be avoided, even if they contain no fat, although water may be allowed.

Keywords

Postprandial metabolismPlasmaMeal eating
Type
Human and Clinical Nutrition
Information
British Journal of Nutrition , Volume 79 , Issue 5 , May 1998 , pp. 425 - 429
Copyright
Copyright © The Nutrition Society 1998

References

Cohn, JS, McNamara, JR, Cohn, SD, Ordovas, JM & Schaefer, EJ (1988) Postprandial plasma lipoprotein changes in human subjects of different ages. Journal of Lipid Research 29, 469–479.CrossRefGoogle ScholarPubMed
Cohn, JS, McNamara, JR, Krasinski, SD, Russell, RM & Schaefer, EJ (1989) Role of triglyceride-rich lipoproteins from the liver and intestine in the etiology of postprandial peaks in plasma triglyceride concentration. Metabolism 38, 484–490.CrossRefGoogle ScholarPubMed
Coppack, SW, Fisher, RM, Gibbons, GF, Humphreys, SM, McDonough, MJ, Potts, JL & Frayn, KN (1990) Postprandial substrate deposition in human forearm and adipose tissues in vivo. Clinical Science 79, 339–348.CrossRefGoogle ScholarPubMed
Coppack, SW, Frayn, KN & Humphreys, SM (1989) Plasma triacylglycerol extraction in human adipose tissue in vivo: effects of glucose ingestion and insulin infusion. European Journal of Clinical Nutrition 43, 493–496.Google ScholarPubMed
Fielding, BA, Callow, J, Owen, RM, Samra, JS, Matthews, DR & Frayn, KN (1996) Postprandial lipemia: the origin of an early peak studied by specific dietary fatty acid intake during sequential meals. American Journal of Clinical Nutrition 63, 36–41.CrossRefGoogle ScholarPubMed
Griffiths, JA, Humphreys, SM, Clark, ML, Fielding, BA & Frayn, KN (1994) Immediate metabolic availability of dietary fat in combination with carbohydrate. American Journal of Clinical Nutrition 59, 53–59.CrossRefGoogle ScholarPubMed
Holland, BA, Welch, AA, Unwin, ID, Buss, DH, Paul, AA & Southgate, DAT (1991). McCance and Widdowson's The Composition of Foods, 5th ed. Cambridge: Royal Society of Chemistry.Google Scholar
Kalogeris, T, Monroe, F, Demichelle, S & Tso, P (1996) Intestinal synthesis and lymphatic secretion of apolipoprotein A-IV vary with chain length of intestinally infused fatty acids in rats. Journal of Nutrition 126, 2720–2729.Google ScholarPubMed
Mattes, RD (1996) Oral fat exposure alters postprandial lipid metabolism in humans. American Journal of Clinical Nutrition 63, 911–917.Google ScholarPubMed
Mendeloff, AI (1954) The effects of eating and of sham feeding upon the absorption of vitamin A palmitate in man. Journal of Clinical Investigation 33, 1015–1021.CrossRefGoogle ScholarPubMed
Patsch, JR, Miesenböck, G, Hopferwieser, T, Mühlberger, V, Knapp, E, Dunn, JK, Gotto, AMJ & Patsch, W (1992) Relation of triglyceride metabolism and coronary artery disease. Studies in the postprandial state. Arteriosclerosis and Thrombosis 12, 1336–1345.CrossRefGoogle ScholarPubMed
Peel, AS, Zampelas, A, Williams, CM & Gould, BJ (1993) A novel antiserum specific to apolipoprotein B-48: application in the investigation of postprandial lipidaemia in humans. Clinical Science 85, 521–524.CrossRefGoogle ScholarPubMed
Schmid-Schonbein, G (1990) Microlymphatics and lymph flow. Physiological Reviews 70, 987–1028.CrossRefGoogle ScholarPubMed
Williams, CM, Moore, F, Morgan, L & Wright, J (1992) Effects of n-3 fatty acids on postprandial triacylglycerol and hormone concentrations in normal subjects. British Journal of Nutrition 68, 655–666.CrossRefGoogle ScholarPubMed