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Rapid chylomicron appearance following sequential meals: effects of second meal composition

Published online by Cambridge University Press:  09 March 2007

Kevin Evans ,
Pertti J. Kuusela ,
Martha L. Cruz ,
Ingrid Wilhelmova ,
Barbara A. Fielding  and
Keith N. Frayn
Kevin Evans
Affiliation:
Nuffield Department of Clinical Biochemistry, John Radcliffe Hospital, Headington, Oxford OX3 9DU, UK
Pertti J. Kuusela
Affiliation:
Oxford Lipid Metabolism Group, Nuffield Department of Clinical Medicine, Radcliffe Infirmary, Oxford OX2 6HE, UK
Martha L. Cruz
Affiliation:
Oxford Lipid Metabolism Group, Nuffield Department of Clinical Medicine, Radcliffe Infirmary, Oxford OX2 6HE, UK
Ingrid Wilhelmova
Affiliation:
Oxford Lipid Metabolism Group, Nuffield Department of Clinical Medicine, Radcliffe Infirmary, Oxford OX2 6HE, UK
Barbara A. Fielding
Affiliation:
Oxford Lipid Metabolism Group, Nuffield Department of Clinical Medicine, Radcliffe Infirmary, Oxford OX2 6HE, UK
Keith N. Frayn*
Affiliation:
Oxford Lipid Metabolism Group, Nuffield Department of Clinical Medicine, Radcliffe Infirmary, Oxford OX2 6HE, UK
*
*Corresponding author: Dr Keith N. Frayn: fax +44(0)1865 224652, email [email protected]
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Abstract

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Previous studies have noted the presence of an early postprandial peak in plasma triacylglycerol concentrations following successive fat-rich meals. An earlier study has shown that the triacylglycerol in this early peak originates from a previous meal. The present study was performed to investigate the effects of different second meals on the plasma triacylglycerol response. Six healthy subjects were studied on four occasions each. At 5 h following a fat-rich breakfast they ingested one of the following in a balanced design: a fat-rich meal, a low-fat meal, water or nothing by mouth. Blood samples were taken for 2.5 h following the second meal. An early peak in chylomicron and plasma triacylglycerol concentrations was seen following both low-fat and fat-rich second meals but not following water. During studies investigating postprandial lipaemia, further meals must be avoided, even if they contain no fat, although water may be allowed.

Keywords

Postprandial metabolismPlasmaMeal eating
Type
Human and Clinical Nutrition
Information
British Journal of Nutrition , Volume 79 , Issue 5 , May 1998 , pp. 425 - 429
Copyright
Copyright © The Nutrition Society 1998

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