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A randomized double-blind controlled calcium supplementation trial, and bone height acquisition in children

Published online by Cambridge University Press:  09 March 2007

Warren T. K. Lee ,
Sophie S. F. Leung ,
Doram. Y. Leung ,
Heidi S. Y. Tsang ,
Joseph Lau  and
Jack C. Y. Cheng
Warren T. K. Lee
Affiliation:
Department of Paediatrics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
Sophie S. F. Leung
Affiliation:
Department of Paediatrics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
Doram. Y. Leung
Affiliation:
Department of Paediatrics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
Heidi S. Y. Tsang
Affiliation:
Department of Paediatrics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
Joseph Lau
Affiliation:
Centre for Clinical Trials and Epidemiology Research, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
Jack C. Y. Cheng
Affiliation:
Department of Orthopaedics, and Traumatology. Faculty of Medicine, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong
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Abstract

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There is limited information relating Ca intake to bone and height acquisition among Oriental children who consume little or even no milk. The present controlled study investigated the acquisition of bone mass and height of Chinese children with an initial Ca intake of approximately 567 mg/d who were supplemented to about 800 mg/d. Eighty-four 7-year-old Hong Kong Chinese children underwent an 18-month randomized, double-blind, controlled Ca-supplementation trial. The children were randomized to receive either 300 mg elemental Ca or a placebo tablet daily. Bone mass of the distal one-third radius was measured by single-photon absorptiometry, lumbar spine and femoral neck were determined using dual-energy X-ray absorptiometry. Measurements were repeated 6-monthly. Baseline serum 25-hydroxycholecalciferol concentration and physical activity were also assessed. Baseline Ca intakes of the study group and controls were respectively 571 (SD 326) and 563 (SD 337) mg/d. There were no significant differences in baseline serum 25-hydroxycholecalciferol concentration (P = 0·71) and physical activity (P = 0·36) between the study and control groups. After 18 months the study group had significantly greater increases in lumbar-spinal bone mineral content (20·9 v. 16. 34%; P = 0·035), lumbar-spinal area (11·16 v. 8·71%; P = 0middot;049), and a moderately greater increment in areal bone mineral density of the radius (7·74 0·600%; P = 0.081) when compared with the controls. The results confirm a positive effect of Ca on bone mass of the spine and radius but no effects on femoral-neck and height increase. A longer trial is warranted to confirm a positive Ca effect during childhood that may modify future peak bone mass.

Keywords

CalciumChildhoodBone
Type
Calcium intake and bone mass in children
Information
British Journal of Nutrition , Volume 74 , Issue 1 , July 1995 , pp. 125 - 139
Copyright
Copyright © The Nutrition Society 1995

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