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Raised saturated-fat intake worsens vascular function in virgin and pregnant offspring of streptozotocin-diabetic rats

Published online by Cambridge University Press:  09 March 2007

Kathleen Holemans ,
Robert Gerber ,
Ivan O'Brien-Coker ,
Anthony Mallet ,
Rieta Van Bree ,
F. André Van Assche  and
Lucilla Poston
Kathleen Holemans*
Affiliation:
Department of Obstetrics and Gynecology, Katholieke Universiteit Leuven, 3000 Leuven, Belgium
Robert Gerber
Affiliation:
Department of Obstetrics and Gynaecology
Ivan O'Brien-Coker
Affiliation:
St John's Institute of Dermatology, Guy's, King's and St. Thomas' School of Medicine, London SE1 7EH, UK
Anthony Mallet
Affiliation:
St John's Institute of Dermatology, Guy's, King's and St. Thomas' School of Medicine, London SE1 7EH, UK
Rieta Van Bree
Affiliation:
Department of Obstetrics and Gynecology, Katholieke Universiteit Leuven, 3000 Leuven, Belgium
F. André Van Assche
Affiliation:
Department of Obstetrics and Gynecology, Katholieke Universiteit Leuven, 3000 Leuven, Belgium
Lucilla Poston
Affiliation:
Department of Obstetrics and Gynaecology
*
*Corresponding author: Dr Kathleen Holemans, fax +32 16 344205, email [email protected]
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Abstract

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Adult offspring of severely diabetic pregnant rats are insulin resistant and display cardiovascular dysfunction. When pregnant they develop mild hyperglycaemia. Diets high in saturated fat have been implicated in the development of cardiovascular disease and vascular dysfunction. In the present study we have determined vascular function in small mesenteric arteries from offspring of normal (OC) and diabetic (OD) rats fed standard chow and offspring of diabetic rats fed a diet high in saturated fats (OD-HF) from weaning to adulthood, and throughout their subsequent pregnancies. OD rats displayed an increased sensitivity to noradrenaline (P < 0·05) and impaired sensitivity to the endothelium-dependent vasodilator, acetylcholine. The component of acetylcholine-induced relaxation attributable to endothelium-derived hyperpolarizing factor was reduced in OD-HF rats. Pregnant OD rats also demonstrated impaired maximum relaxation to acetylcholine (pregnant OD rats v. pregnant OC rats P < 0·05). In pregnant OD-HF rats noradrenaline sensitivity was enhanced and endothelium-dependent relaxation further reduced (pregnant OD-HF rats v. pregnant OC rats P < 0·001). The isoprostane, 8-epi-prostaglandin F2α, a marker of oxidative stress, was increased in pregnant OD rats (pregnant OD rats v. pregnant OC rats P < 0·001) and further increased in pregnant OD-HF rats (pregnant OD-HF rats v. pregnant OD rats P < 0·05). We conclude that a high-saturated-fat diet leads to deterioration in specific components of vascular function in OD rats. When pregnant, vascular function of OD-HF rats is further compromised. Pregnancy in the OD rats is associated with a striking increase in a marker of oxidative stress, which increases further if the saturated fat intake is raised.

Keywords

DiabetesPregnancyHigh-fat dietVascular function
Type
Research Article
Information
British Journal of Nutrition , Volume 84 , Issue 3 , September 2000 , pp. 285 - 296
Copyright
Copyright © The Nutrition Society 2000

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