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A proposed intestinal mechanism for the effect of riboflavin deficiency on iron loss in the rat

Published online by Cambridge University Press:  09 March 2007

Hilary J. Powers ,
Lawrence T. Weaver ,
Steven Austin  and
John K. Beresford
Hilary J. Powers
Affiliation:
University Department of Paediatrics, The Stephenson Unit, Sheffield Children's Hospital, Western Bank, Sheffield S1O 2TH
Lawrence T. Weaver
Affiliation:
Medical Research Council, Dunn Nutritional Laboratory, Downhams Lane, Milton Road, Cambridge CB4 lXJ
Steven Austin
Affiliation:
Medical Research Council, Dunn Nutritional Laboratory, Downhams Lane, Milton Road, Cambridge CB4 lXJ
John K. Beresford
Affiliation:
University Department of Paediatrics, The Stephenson Unit, Sheffield Children's Hospital, Western Bank, Sheffield S1O 2TH
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Abstract

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The effect of riboflavin deficiency on gastrointestinal Fe distribution and loss was studied in weanling rats. Riboflavin deficiency was associated with a significant increase in crypt depth in the upper and mid small intestine and a twofold increase in the rate of crypt cell production compared with weight-matched and ad lih.-fed control rats. The rate of loss of endogenous Fe, measured as faecal 59Fe after intraperitoneally administered 59Fe, was twice that from riboflavin-deficient rats compared with weightmatched controls. We suggest that while there may be a contribution from turnover of enterocytes with an enhanced Fe content, enhanced Fe loss associated with riboflavin deficiency is due predominantly to an accelerated rate of small-intestinal epithelial turnover.

Keywords

Riboflavin deficiencyIronRatCell turnoverSmall intestine
Type
Interactions Between Riboflavin Status and Iron
Information
British Journal of Nutrition , Volume 69 , Issue 2 , March 1993 , pp. 553 - 561
Copyright
Copyright © The Nutrition Society 1993

References

REFERENCES

Adelckan, D. A. & Thurnham, D. I. (1986). A longitudinal study of the effect of riboflavin status on aspects of iron storage in the liver of growing rats. British Journul of Nutrition 56, 171–179.CrossRefGoogle Scholar
Bessey, V. A., Lowry, V. H. & Love, R. H. (1949). The fluorimetric measurement of the nucleotides of riboflavin and their concentration in tissues. Journal of Biological Chemistry 180, 755–769.CrossRefGoogle Scholar
Buzina, R., Jusic, M., Milanovic, N., Sapunar, J. & Brubacher, G. (1979). The effects of riboflavin administration on iron metabolism parameters in a school-going population. International Journal of Vitamin and Nutrition Research 49, 136–143.Google Scholar
Duerden, J. M. & Bates, C. J. (1985). Effect of riboflavin deficiency on reproductive performance and on biochemical indices of riboflavin status in the rat. British Journul of Nutrition 53, 97–105.CrossRefGoogle ScholarPubMed
Goodlad, R. A., Plumb, J. A. & Wright, N. A. (1988). Epithelial cell proliferation and intestinal absorptive function during starvation and refeeding in the rat. Clinical Science 25, 301–306.CrossRefGoogle Scholar
Powers, H. J. (1986). Investigation into the relative effects of riboflavin deficiency in the weanling rat and the adult. Annals of Nutrition and Metabolism 30, 308 315.CrossRefGoogle ScholarPubMed
Powers, H. J. (1987). A study of maternofetal iron transfer in the riboflavin deficient rat. Journal of Nutrition 117, 852–856.CrossRefGoogle ScholarPubMed
Powers, H. J., Bates, C. J. & Duerden, J. M. (1983). Effects of riboflavin deficiency in rats on some aspects of iron metabolism. International Journul of Vitamin and Nutrition Re.search 43, 371–376.Google Scholar
Powers, H. J., Weaver, L. T., Austin, S., Wright, A. J. A. & Fairweather-Tait, S. J. (1991). Riboflavin deficiency in the rat: effects on iron utilization and loss. British Journal of Nutrition 65, 487–496.CrossRefGoogle ScholarPubMed
Powers, H. J., Wright, A. J. A. & Fairweather-Tait, S. J. (1988). The effect of riboflavin deficiency on the absorption and distribution of iron. British Journal of Nutrition 59. 381–387.CrossRefGoogle Scholar
Sauberlich, H. E., Skala, J. H. & Dowdy, R. P. (1974). Laboratory Tests fhr the Assessment of Nutritional Status. Cleveland, Ohio: CRC Press, Inc.Google Scholar
Weaver, L. T. & Carrick, B. M. (1989). Changes in upper intestinal morphology and kinetics in the growing guinea pig. Paediatric Research 26, 31–33.CrossRefGoogle ScholarPubMed
Wright, N. A. & Irwin, M. (1982). The kinetics of villus cell populations in the mouse small intestine. Cell and Tissue Kinetics 15, 595609.Google ScholarPubMed