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Probiotics: on-going research on atopic individuals

Published online by Cambridge University Press:  09 March 2007

K. Laiho ,
U. Hoppu ,
A. C. Ouwehand ,
S. Salminen  and
E. Isolauri
K. Laiho
Affiliation:
Department of Paediatrics, University of Turku, 20520 Turku, Finland
U. Hoppu
Affiliation:
Department of Paediatrics, University of Turku, 20520 Turku, Finland
A. C. Ouwehand
Affiliation:
Department of Biochemistry and Food Chemistry, University of Turku, Finland
S. Salminen
Affiliation:
Department of Biochemistry and Food Chemistry, University of Turku, Finland
E. Isolauri*
Affiliation:
Department of Paediatrics, University of Turku, 20520 Turku, Finland
*
*Corresponding author:Dr E. Isolauri, tel +358 2 3131611, fax +358 2 3131460, email [email protected]
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Abstract

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The challenge for the modern health care system is to fight against the increasing prevalence of atopic disease. The introduction of scientifically composed probiotic functional foods for prophylactic or therapeutic purposes could be one solution. Probiotics are live microbial food supplements or components of bacteria which have beneficial effects on human health. Specific strains have been demonstrated to exert powerful anti-pathogenic, anti-inflammatory and anti-allergic effects. The hygiene hypothesis suggests that atopic disease may arise from a lack of counterbalancing microbial exposure at an early age. The initial compositional development of the gut microflora is considered a key determinant of the development of both the immune responder phenotype and normal gut barrier functions. The regulatory role of probiotics in human allergic disease was first emphasised in the demonstration of a suppressive effect on lymphocyte proliferation and interleukin-4 generation in vitro. Subsequently, a significant improvement in the clinical course of atopic eczema was reported in infants given a probiotic-supplemented diet. The potential of probiotics to reduce the risk of atopic disease has recently been demonstrated in a double-blind, placebo-controlled study: probiotics administered pre- and postnatally for 6 months to at-risk subjects reduced the prevalence of atopic eczema to half of that observed in infants receiving placebo. Ongoing research is directed towards the development of novel techniques to characterise the gut microflora. Future research will clarify the mechanisms to control specific physiological processes in the evolution of atopic disease in at-risk populations or in the management of allergic diseases.

Keywords

ProbioticsAtopic diseaseFunctional foods
Type
Research Article
Information
British Journal of Nutrition , Volume 88 , Issue S1 , September 2002 , pp. s19 - s27
Copyright
Copyright © The Nutrition Society 2002

References

Armentia, A, Banuelos, C, Arranz, ML, Del Villar, V, Martin-Santos, J-M, Gil, FJM, Vega, JM, Callejo, A & Paredes, C (2001) Early introduction of cereals into children's diets as a risk-factor for grass pollen asthma. Clinical and Experimental Allergy 31, 1250–1255.CrossRefGoogle ScholarPubMed
Barone, KS, Reilly, MR, Flanagan, MP & Michael, JG (2000) Abrogation of oral tolerance by feeding encapsulated antigen. Cellular Immunology 199, 65–72.CrossRefGoogle ScholarPubMed
Benno, Y, He, F, Hosoda, M, Hashimoto, H, Kojima, T, Yamazaki, K, Iino, H, Mykkänen, H & Salminen, S (1996) Effect of Lactobacillus GG yogurt on human intestinal microecology in Japanese subjects. Nutrition Today 31, Suppl. 6, 9S–11S.CrossRefGoogle Scholar
Benno, Y & Mitsuoka, T (1986) Development of intestinal microflora in humans and animals. Bifidobacteria and Microflora 5, 18–25.CrossRefGoogle Scholar
Berg, RD (1996) The indigenous gastrointestinal microflora. Trends in Microbiology 4, 430–435.CrossRefGoogle ScholarPubMed
Bergmann, RL, Edenharter, G, Bergmann, KE, Forster, J, Bauer, CP, Wahn, V, Zepp, F & Wahn, U (1998) Atopic dermatitis in early infancy predicts allergy airway disease at 5 years. Clinical and Experimental Allergy 28, 965–970.CrossRefGoogle ScholarPubMed
Biagi, PL, Hrelia, S, Celadon, M, Turchetto, E, Masi, M, Ricci, G, Specchia, F, Cannella, MV, Horrobin, DF & Bordoni, A (1993) Erythrocyte membrane fatty acid composition in children with atopic dermatitis compared to age-matched controls. Acta Paediatrica 82, 789–790.CrossRefGoogle ScholarPubMed
Björkstén, B, Naaber, P, Sepp, E & Mikelsaar, M (1999) The gut microflora in allergic Estonian and Swedish 2-year-old children. Clinical and Experimental Allergy 29, 342–346.CrossRefGoogle Scholar
Black, PN & Sharpe, S (1997) Dietary fat and asthma: is there a connection? European Respiratory Journal 10, 6–12.CrossRefGoogle ScholarPubMed
Bolte, G, Frye, C, Hoelscher, B, Meyer, I, Wjst, M & Heinrich, J (2001) Margarine consumption and allergy in children. American Journal of Respiratory and Critical Care Medicine 163, 277–279.CrossRefGoogle ScholarPubMed
Bottcher, MF, Nordin, EK, Sandin, A, Midtvedt, T & Björkstén, B (2000) Microflora-associated characteristics in faeces from allergic and non-allergic infants. Clinical and Experimental Allergy 30, 1590–1596.CrossRefGoogle Scholar
Calder, PC (1997) n-3 polyunsaturated fatty acids and cytokine production in health and disease. Annals of Nutrition and Metabolism 41, 203–234.CrossRefGoogle ScholarPubMed
Cant, A, Marsden, RA & Kilshaw, PJ (1985) Egg and cow's milk hypersensitivity in exclusively breast fed infants with eczema and detection of egg protein in breast milk. British Medical Journal 291, 932–935.CrossRefGoogle ScholarPubMed
Cook, DG, Carey, IM, Whincup, PH, Papacosta, O, Chirico, S, Bruckdorfer, KR & Walker, M (1997) Effect of fresh fruit consumption on lung function and wheeze in children. Thorax 52, 628–633.CrossRefGoogle ScholarPubMed
Diplock, AT, Aggett, P, Ashwell, M, Bornet, F, Fern, E & Roberfroid, M (1999) Scientific concepts of functional foods in Europe: consensus document. British Journal of Nutrition 81, Suppl. 1, S1–S27.Google Scholar
Dunder, T, Kuikka, L, Turtinen, J, Räsänen, L & Uhari, M (2001) Diet, serum fatty acids, and atopic disease in childhood. Allergy 56, 425–428.CrossRefGoogle ScholarPubMed
Fogarty, A, Lewis, S, Weiss, S & Britton, J (2000) Dietary vitamin E, IgE concentration and atopy. Lancet 356, 1573–1574.CrossRefGoogle ScholarPubMed
Gibson, GR & Roberfroid, MB (1995) Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. Journal of Nutrition 125, 1401–1412.CrossRefGoogle ScholarPubMed
Greene, LS (1999) Asthma, oxidant stress and diet. Nutrition 15, 899–907.CrossRefGoogle ScholarPubMed
Grönlund, MM, Arvilommi, H, Kero, P, Lehtonen, OP & Isolauri, E (2000) Importance of intestinal colonisation in the maturation of humoral immunity in early infancy: a prospective follow up study of healthy infants aged 0 – 6. months. Archives of Disease in Childhood 83, F186–F192.CrossRefGoogle ScholarPubMed
Haby, MM, Peat, JK, Marks, GB, Woolcock, AJ & Leeder, SR (2001) Asthma in preschool children: prevalence and risk factors. Thorax 56, 589–595.CrossRefGoogle ScholarPubMed
He, F, Ouwehand, AC, Isolauri, E, Hashimoto, H, Benno, Y & Salminen, S (2001) Comparison of mucosal adhesion and species identification of bifidobacteria isolated from healthy and allergic infants. FEMS Immunology and Medical Microbiology 30, 43–47.CrossRefGoogle ScholarPubMed
Helgeland, L & Brandtzaeg, P (2000) Development and function of intestinal B and T cells. Microbial Ecology in Health and Disease 11, S110–S127.Google Scholar
Hodge, L, Salome, CM, Peat, JK, Haby, M, Xuan, M & Woolcock, AJ (1996) Consumption of oily fish and childhood asthma risk. Medical Journal of Australia 164, 137–140.CrossRefGoogle ScholarPubMed
Holma, R, Salmenpera, P, Lohi, J, Vapaatalo, H & Korpela, R (2001) Effects of Lactobacillus rhamnosus GG and Lactobacillus reuteri R2LC on acetic acid-induced colitis in rats. Scandinavian Journal of Gastroenterology 36, 630–635.CrossRefGoogle ScholarPubMed
Hoppu, U, Kalliomäki, M & Isolauri, E (2000) Maternal diet rich in saturated fat during breastfeeding is associated with atopic sensitization of the infant. European Journal of Clinical Nutrition 54, 702–705.CrossRefGoogle Scholar
Isolauri, E, Arvola, T, Sütas, Y, Moilanen, E & Salminen, S (2000) Probiotics in the management of atopic eczema. Clinical and Experimental Allergy 30, 1604–1610.CrossRefGoogle ScholarPubMed
Isolauri, E, Majamaa, H, Arvola, T, Rantala, I, Virtanen, E & Arvilommi, H (1993) Lactobacillus casei strain GG reverses increased intestinal permeability induced by cow milk in suckling rats. Gastroenterology 105, 1643–1650.CrossRefGoogle ScholarPubMed
Isolauri, E & Turjanmaa, K (1995) Combined skin prick and patch testing enhances identification of food allergy in infants with atopic dermatitis. Journal of Allergy and Clinical Immunology 97, 9–15.CrossRefGoogle Scholar
Jones, CA, Holloway, JA & Warner, JO (2000) Does atopic disease start in foetal life? Allergy 55, 2–10.CrossRefGoogle ScholarPubMed
Kalliomäki, M, Kirjavainen, P, Eerola, E, Kero, P, Salminen, S & Isolauri, E (2001a) Distinct patterns of neonatal gut microflora in infants developing or not developing atopy. Journal of Allergy Clinical Immunology 107, 129–134.CrossRefGoogle ScholarPubMed
Kalliomäki, M, Salminen, S, Arvilommi, H, Kero, P, Koskinen, P & Isolauri, E (2001b) Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial. Lancet 357, 1076–1079.CrossRefGoogle ScholarPubMed
Kero, J, Gissler, M, Hemminki, E & Isolauri, E (2001) Could the TH1 and TH2 diseases coexist? Evaluation of asthma incidence in children with coeliac disease, type 1 diabetes or rheumatoid arthritis – a register study. Journal of Allergy and Clinical Immunology 108, 781–783.CrossRefGoogle ScholarPubMed
Kilburn, SA, Pollard, C, Bevin, S, Hourihane, JO'B, Warner, JO & Dean, T (1998) Allergens in mothers milk: tolerisation or sensitisation. Nutrition Research 18, 1351–1361.CrossRefGoogle Scholar
Kirjavainen, PV, Apostolou, E, Salminen, SJ & Isolauri, E (1999) New aspects of probiotics – a novel approach in the management of food allergy. Allergy 54, 909–915.CrossRefGoogle ScholarPubMed
Klinman, DM, Yi, A-K, Beaucage, SL, Conover, J & Krieg, AM (1996) CpG motifs present in bacterial DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12 and interferon-γ. Proceedings of the National Academy of Sciences 93, 2879–2883.CrossRefGoogle ScholarPubMed
Lee, YK, Lim, CY, Teng, WL, Ouwehand, AC, Tuomola, EM & Salminen, S (2000) Quantitative approach in the study of adhesion of lactic acid bacteria to intestinal cells and their competition with enterobacteria. Applied and Environmental Microbiology 66, 3692–3697.CrossRefGoogle Scholar
Leichsenring, M, Kochsiek, U & Paul, K (1995) (n-6)-Fatty acids in plasma lipids of children with atopic bronchial asthma. Pediatric Allergy and Immunology 6, 209–212.CrossRefGoogle ScholarPubMed
Majamaa, H, Isolauri, E, Saxelin, M & Veskari, T (1995) Lactic acid bacteria in the treatment of acute rotavirus gastroenteritis. Journal of Pediatric Gastroenterology and Nutrition 20, 333–338.Google ScholarPubMed
Matsuzaki, T, Yamazaki, R, Hashimoto, S & Yokokura, T (1998) The effect of oral feeding of Lactobacillus casei strain Shirota on immunoglobulin E production in mice. Journal of Dairy Science 81, 48–53.CrossRefGoogle ScholarPubMed
Morata de Ambrosini, V, Gonzales, S, de Ruiz Holgado, AP & Oliver, G (1998) Study of the morphology of the cell walls of some strains of lactic acid bacteria and related species. Journal of Food Protection 61, 557–562.CrossRefGoogle Scholar
Moreau, MC, Ducluzeau, R, Guy-Grand, D & Muller, MC (1978) Increase in the population of duodenal IgA plasmocytes in axenic mice monoassociated with different living or dead bacterial strains of intestinal origin. Infection and Immunity 21, 532–539.CrossRefGoogle ScholarPubMed
Newberry, RD, Stenson, WF & Lorenz, RG (1999) Cyclooxygenase-2-dependent arachidonic acid metabolites are essential modulators of the intestinal immune response to dietary antigen. Nature Medicine 5, 900–906.CrossRefGoogle ScholarPubMed
Nikoskelainen, S, Salminen, S, Bylund, G & Ouwehand, AC (2001) Characterization of the properties of human-and dairy-derived probiotics for prevention of infectious disease in fish. Applied and Environmental Microbiology 67, 2430–2435.CrossRefGoogle Scholar
Ouwehand, AC, Isolauri, E, He, F, Hashimoto, H, Benno, Y & Salminen, S (2001) Differences in Bifidobacterium flora composition in allergic and healthy infants. Journal of Allergy and Clinical Immunology 108, 144–145.CrossRefGoogle ScholarPubMed
Pessi, T, Sütas, Y, Marttinen, A & Isolauri, E (1998) Probiotics reinforce mucosal degradation of antigens in rats: implications for therapeutic use of probiotics. Journal of Nutrition 128, 1312–1318.CrossRefGoogle ScholarPubMed
Pessi, T, Sütas, Y, Saxelin, M, Kalloinen, H & Isolauri, E (1999) Antiproliferative effects of homogenates derived from five strains of candidate probiotic bacteria. Applied and Environmental Microbiology 65, 4725–4728.CrossRefGoogle ScholarPubMed
Piccinni, MP, Beloni, L, Livi, C, Maggi, E, Scarselli, G & Romagnani, S (1998) Defective production of both leukemia inhibitory factor and type 2 T-helper cytokines by decidual T-cells in unexplained recurrent abortions. Nature Medicine 4, 1020–1024.CrossRefGoogle ScholarPubMed
Pickering, LK, Granoff, DM, Reed Erickson, J, Masor, ML, Cordle, CT, Schaller, JP, Winship, TR, Paule, CL & Hilty, MD (1998) Modulation of the immune system by human milk and infant formula containing nucleotides. Pediatrics 101, 242–249.CrossRefGoogle ScholarPubMed
Platts-Mills, T, Vaughan, J, Squillace, S, Woodfolk, J & Sporik, R (2001) Sensitisation, asthma and a modified Th2 response in children exposed to cat allergen: a population-based cross-sectional study. Lancet 357, 752–756.CrossRefGoogle Scholar
Prescott, SL, Macaubas, C, Smallacombe, T, Holt, BJ, Sly, PD & Holt, PG (1999) Development of allergen-specific T-cell memory in atopic and normal children. Lancet 353, 196–200.CrossRefGoogle ScholarPubMed
Rinkinen, M, Mättö, J, Salminen, S, Westermarck, E & Ouwehand, AC (2000) In vitro adhesion of lactic acid bacteria to canine small intestinal mucus. Journal of Animal Physiology and Animal Nutrition 84, 43–47.CrossRefGoogle Scholar
Roberfroid, MB (2001) Prebiotics: preferential substrates for specific germs? American Journal of Clinical Nutrition 73, Suppl. 2, 406–409.CrossRefGoogle ScholarPubMed
Romagnani, S, Parronchi, P, D'Elios, MM, Romagnani, P, Annunziato, F, Piccinni, M-P, Manetti, R, Sampognaro, S, Mavilia, C, De-Carli, M, Maggi, E & Del-Prete, GF (1997) An update on human Th1 and Th2 cells. International Archives of Allergy and Immunology 113, 153–156.CrossRefGoogle ScholarPubMed
Roper, RL, Brown, DM & Phipps, P (1992) Prostaglandin E2 and cAMP inhibit B lymphocyte activation and simultaneously promote IgE and IgG1 synthesis. Journal of Immunology 149, 2984–2991.CrossRefGoogle ScholarPubMed
Roper, RL, Brown, DM & Phipps, P (1995) Prostaglandin E2 promotes B lympocyte Ig isotype switching to IgE. Journal of Immunology 154, 162–170.CrossRefGoogle Scholar
Salminen, S, Bouley, C, Boutron-Ruault, M-C, Cummings, JH, Franck, A, Gibson, GR, Isolauri, E, Moreau, M-C, Roberfroid, M & Rowland, I (1998) Functional food science and gastrointestinal physiology and function. British Journal of Nutrition 80, Suppl. 1, S147–S171.CrossRefGoogle ScholarPubMed
Salminen, S, Ouwehand, A, Benno, Y & Lee, YK (1999) Probiotics: how should they be defined? Trends in Food Science and Technology 10, 107–110.CrossRefGoogle Scholar
Sanders, ME (2000) Considerations for use of probiotic bacteria to modulate human health. Journal of Nutrition 130, Suppl. 2, S384–S390.CrossRefGoogle ScholarPubMed
Sanfilippo, L, Li, CK, Seth, R, Balwin, TJ, Menozzi, MG & Mahida, YR (2000) Bacteroides fragilis enterotoxin induces the expression of IL-8 and transforming growth factor-beta (TGF-beta) by human colonic epithelial cells. Clinical and Experimental Immunology 119, 456–463.CrossRefGoogle ScholarPubMed
Soutar, A, Seaton, A & Brown, K (1997) Bronchial reactivity and dietary antioxidants. Thorax 52, 166–170.CrossRefGoogle ScholarPubMed
Stene, LC & Nafstad, P (2001) Relation between occurrence of type 1 diabetes and asthma. Lancet 357, 607–608.CrossRefGoogle ScholarPubMed
Stewart-Tull, DES (1980) The immunological activities of bacterial peptidoglycans. Annual Reviews of Microbiology 34, 311–340.CrossRefGoogle ScholarPubMed
Strachan, DP (1989) Hay fever, hygiene, and household size. British Medical Journal 299, 1259–1260.CrossRefGoogle ScholarPubMed
Sudo, N, Sawamura, S, Tanaka, K, Aiba, Y, Kubo, C & Koga, Y (1997) The requirement of intestinal bacterial flora for the development of an IgE production system fully susceptible to oral tolerance induction. Journal of Immunology 159, 1739–1745.CrossRefGoogle ScholarPubMed
Sütas, Y, Hurme, M & Isolauri, E (1996) Down-regulation of anti-CD3 antibody-induced IL-4 production by bovine caseins hydrolysed with Lactobacillus GG-derived enzymes. Scandinavian Journal of Immunology 43, 687–689.CrossRefGoogle ScholarPubMed
Szepfalusi, Z, Nentwich, I, Gertsmayr, M, Jost, E, Todoran, L, Gratzl, R, Herkner, K & Urbanek, R (1997) Prenatal allergen contact with milk proteins. Clinical and Experimental Allergy 27, 28–35.CrossRefGoogle ScholarPubMed
Tejada-Simon, MV & Pestka, JJ (1999) Proinflammatory cytokine and nitric oxide induction in murine macrophages by cell wall and cytoplasmic extracts of lactic acid bacteria. Journal of Food Protection 62, 1435–1444.CrossRefGoogle ScholarPubMed
Whelan, J (1996) Antagonist effects of dietary arachidonic acid and n-3 polyunsaturated fatty acids. Journal of Nutrition 126, Suppl. 4, S1086–S1091.CrossRefGoogle Scholar
Willett, W & Buzzard, M (1998) Foods and nutrients. In Nutritional Epidemiology, pp. 18–32 [Willett, W, editor]. New York: Oxford University Press.CrossRefGoogle Scholar
Wollowski, I, Rechkemmer, G & Pool-Zobel, BL (2001) Protective role of probiotics and prebiotics in colon cancer. American Journal of Clinical Nutrition 73, Suppl., 451S–455S.CrossRefGoogle ScholarPubMed
Yasui, H, Nagaoka, N, Mike, A, Hayakawa, K & Ohwaki, M (1992) Detection of Bifidobacterium strains that induce large quantities of IgA. Microbial Ecology in Health and Disease 5, 155–162.CrossRefGoogle Scholar
Yu, G, Duchén, K & Björkstén, B (1998) Fatty acid composition in colostrum and mature milk from non-atopic and atopic mothers during the first 6 months of lactation. Acta Paediatrica 87, 729–736.CrossRefGoogle ScholarPubMed
Zeiger, RS (1994) Dietary manipulations in infants and their mothers and the natural course of atopic disease. Pediatric Allergy and Immunology 5, Suppl. 6, S33–S43.CrossRefGoogle ScholarPubMed
Zeiger, RS & Heller, S (1995) The development and prediction of atopy in high-risk children: follow-up at age seven years in a prospective randomized study of combined maternal and infant food allergen avoidance. Journal of Allergy and Clinical Immunology 95, 1179–1190.CrossRefGoogle Scholar