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Prevention of colon cancer by pre- and probiotics: evidence from laboratory studies

Published online by Cambridge University Press:  11 January 2019

Bandaru S. Reddy
Bandaru S. Reddy*
Affiliation:
American Health Foundation, Valhalla, New York 10595, USA
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Abstract

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Oligofructose and inulin, selective fermentable chicory fructans, have been shown to stimulate the growth of bifidobacteria which are regarded as beneficial strains in the colon. Studies were designed to evaluate inulin (Raftiline) and oligofructose (Raftilose), for their potential inhibitory properties against aberrant crypt foci (ACF) formation in the colon of rats. ACF are putative preneoplastic lesions from which adenomas and carcinomas may develop. The results of this study demonstrate that dietary administration of oligofructose and inulin inhibits the formation of preneoplastic lesions in the colon suggesting the potential colon tumour inhibitory properties of chicory fructans. Since these prebiotics selectively stimulate the growth of bifidobacteria, tumour inhibitory activity of lyophilized cultures of Bifidobacterium longum (BL) against azoxymethane (AOM)-induced colon carcinogenesis in rats and modulating effect of these cultures on colonic tumour cell proliferation, ornithine decarboxylase (ODC) activity, and ras-p21 oncoprotein expression were investigated. Dietary administration of lyophilized cultures of BL strongly suppressed AOM-induced colon tumour development. Inhibition of colon carcinogenesis was associated with a decrease in colonic mucosal cell proliferation and colonic mucosal and tumour ODC and ras-p21 activities.

Keywords

Colon cancerOligofructoseInulinBifidobacterium longum
Type
Research Article
Information
British Journal of Nutrition , Volume 80 , supplement S2: Pre- and Probiotics: Where are We Today? , October 1998 , pp. S219 - S223
Copyright
Copyright © The Nutrition Society 1998

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