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Prenatal exposure to maternal undernutrition induces adult cardiac dysfunction

Published online by Cambridge University Press:  08 March 2007

Kuljeet K. Cheema ,
Melissa R. Dent ,
Harjot K. Saini ,
Nina Aroutiounova  and
Paramjit S. Tappia
Kuljeet K. Cheema
Affiliation:
Institute of Cardiovascular Sciences, St. Boniface Hospital Research Centre & Department of Human Nutritional Sciences, Faculty of Human Ecology, University of Manitoba, Winnipeg, 351 Tache Avenue, Winnipeg, Manitoba, Canada, R2H 2A6
Melissa R. Dent
Affiliation:
Institute of Cardiovascular Sciences, St. Boniface Hospital Research Centre & Department of Human Nutritional Sciences, Faculty of Human Ecology, University of Manitoba, Winnipeg, 351 Tache Avenue, Winnipeg, Manitoba, Canada, R2H 2A6 Institute of Cardiovascular Sciences, St. Boniface Hospital Research Centre & Department of Physiology, Faculty of Medicine, University of Manitoba, 351 Tache Avenue, Winnipeg, Manitoba, Canada, R2H 2A6
Harjot K. Saini
Affiliation:
Institute of Cardiovascular Sciences, St. Boniface Hospital Research Centre & Department of Physiology, Faculty of Medicine, University of Manitoba, 351 Tache Avenue, Winnipeg, Manitoba, Canada, R2H 2A6
Nina Aroutiounova
Affiliation:
Institute of Cardiovascular Sciences, St. Boniface Hospital Research Centre & Department of Human Nutritional Sciences, Faculty of Human Ecology, University of Manitoba, Winnipeg, 351 Tache Avenue, Winnipeg, Manitoba, Canada, R2H 2A6
Paramjit S. Tappia*
Affiliation:
Institute of Cardiovascular Sciences, St. Boniface Hospital Research Centre & Department of Human Nutritional Sciences, Faculty of Human Ecology, University of Manitoba, Winnipeg, 351 Tache Avenue, Winnipeg, Manitoba, Canada, R2H 2A6
*
*Corresponding author: IDr Paramjit S. Tappia, fax +1 204 233 6723, email [email protected]
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Abstract

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An adverse environmental experience of the growing fetus may lead to permanent changes in the structure and function of organs that may predispose the individual to chronic diseases in later life; however, nothing is known about the occurrence and mechanisms of heart failure. We employed a rat model in which pregnant dams were fed diets containing either 180 g (normal) or 90 g (low) casein/kg for 2 weeks before mating and throughout pregnancy. The ejection fraction (EF) of the pups exposed to the low-protein (LP) diet was severely depressed in the first 2 weeks of life and was associated with an increase in cardiomyocyte apoptosis. This early depressed cardiac function was followed by progressive recovery and normalization of the EF of the offspring in the LP group. The left ventricular (LV) internal diameters were increased between 24 h and 84 d (12 weeks) of age in the LP-exposed group. Although between 3 d and 2 weeks of age the LV wall of the heart in the LP group was thinner, a progressive increase in LV wall thickness was seen. At 40 weeks of age, although the EF was normal, a two-fold elevation in LV end-diastolic pressure, reduced cardiac output, decreased maximum rates of contraction and relaxation, and reduced mean arterial pressure were observed. Our findings demonstrate that exposure of the developing fetus to a maternal LP diet programs cardiac dysfunction in the offspring in later life.

Keywords

Low-protein dietCardiomyocyte apoptosisCardiac hypertrophyHeart dysfunction
Type
Research Article
Information
British Journal of Nutrition , Volume 93 , Issue 4 , April 2005 , pp. 471 - 477
Copyright
Copyright © The Nutrition Society 2005

References

Adair, LS, Kuzawa, CW & Borja, J (2001) Maternal energy stores and diet composition during pregnancy program adolescent blood pressure. Circulation 104, 1034–1039.CrossRefGoogle ScholarPubMed
Aihie, Sayer A, Dunn, R, Langley-Evans, SC, Cooper, C (2001) Prenatal exposure to a maternal low protein diet shortens life span in rats. Gerontology 47, 9–14.Google Scholar
Al-Ghazali, W, Cita, SK, Chapman, MG & Allan, LD (1989) Evidence of redistribution of cardiac output in asymmetrical growth retardation. Br J Obstet Gynaecol 96, 697–704.CrossRefGoogle ScholarPubMed
Barker, DJP (1997) Fetal nutrition and cardiovascular disease in later life. Br Med Bull 53, 96–108.CrossRefGoogle ScholarPubMed
Barker, DJP, Eriksson, JG, Forsen, T & Osmond, C (2002) Fetal origins of adult disease: strength of effects and biological basis. Int J Epidemiol 31, 1235–1239.CrossRefGoogle ScholarPubMed
Cianfarani, S, Germani, D & Branca, F (1999) Low birthweight and adult insulin resistance: the ‘catch-up growth’ hypothesis. Arch Dis Child Fetal Neonatal Ed 81, F71–F73.Google Scholar
Erokhina, IL, Selivanova, GV, Vlasova, TD, Emel'ianova, OI & Lagutenko, OI (2000) Mitotic activity, ploidy and ultrastructure of cardiomyocytes from human embryo and fetuses. Tsitologiia 42, 146–153.Google ScholarPubMed
Fall, CHD, Osmond, C, Barker, DJP, Clark, PM, Hales, CN, Stirling, Y & Meade, TW (1995) Fetal and infant growth and cardiovascular risk factors in women. Br Med J 310, 428–432.CrossRefGoogle ScholarPubMed
Godfrey, KM, Barker, DJ, Robinson, S & Osmond, C (1997) Maternal birthweight and diet in pregnancy in relation to the infant's thinness at birth. Br J Obstet Gynaecol 104, 663–667.CrossRefGoogle Scholar
Henein, MY (1999) Long axis function in disease. Heart 81, 229–231.CrossRefGoogle ScholarPubMed
Henriksen, T & Clausen, T (2002) The fetal origins hypothesis: placental insufficiency and inheritance versus maternal malnutrition in well-nourished populations. Acta Obstet Gynecol Scand 81, 112–116.CrossRefGoogle ScholarPubMed
Huxley, R, Neil, A & Collins, R (2002) Unravelling the fetal origins hypothesis: is there really an inverse association between birthweight and subsequent blood pressure?. Lancet 360, 659–665.CrossRefGoogle ScholarPubMed
Jennings, BJ, Ozanne, SE, Dorling, MW & Hales, CN (1999) Early growth determines longevity in male rats and may be related to telomere shortening in the kidney. FEBS Lett 448, 4–8.CrossRefGoogle ScholarPubMed
Johansson, M & Rasmussen, F (2001) Birthweight and body mass index in young adulthood: the Swedish young male twins study. Twin Res 4, 400–405.CrossRefGoogle ScholarPubMed
Krishnaswamy, K, Naidu, AN, Prasad, MP & Reddy, GA (2002) Fetal nutrition and adult chronic disease. Nutr Rev 60, S35–S39.CrossRefGoogle ScholarPubMed
Langley, SC & Jackson, AA (1994) Increased systolic blood pressure in adult rats induced by fetal exposure to maternal low protein diets. Clin Sci 86, 217–222.CrossRefGoogle ScholarPubMed
Langley-Evans, SC, Welham, SJ, Sherman, RC & Jackson, AA (1996) Weanling rats exposed to maternal low-protein diets during discrete periods of gestation exhibit differing severity of hypertension. Clin Sci 91, 607–615.Google Scholar
Lucas, A, Fewtrell, MS & Cole, TJ (1999) Fetal origins of adult disease – the hypothesis revisited. Br Med J 319, 245–249.CrossRefGoogle ScholarPubMed
Malhotra, R & Brosius, FC III (1999) Glucose uptake and glycolysis reduce hypoxia-induced apoptosis in cultured neonatal rat cardiac myocytes. J Biol Chem 274, 12567–12575.CrossRefGoogle ScholarPubMed
Mandinov, L, Eberli, FR, Seiler, C & Hess, OM (2000) Diastolic heart failure. Cardiovasc Res 45, 813–825.CrossRefGoogle ScholarPubMed
Oxenham, H & Sharpe, N (2003) Cardiovascular aging and heart failure. Eur J Heart Fail 5, 427–434.CrossRefGoogle ScholarPubMed
Rizzo, G & Arduini, D (1991) Fetal cardiac function in intrauterine growth retardation. Am J Obstet Gynecol 165, 876–882.CrossRefGoogle ScholarPubMed
Sabbah, HN (2003) The cardiac support device and the myosplint: treating heart failure by targeting left ventricular size and shape. Ann Thorac Surg 75, S13–S19.Google Scholar
Severi, FM, Rizzo, G, Bocchi, C, D'Antona, D, Verzuri, MS & Arduini, D (2000) Intrauterine growth retardation and fetal cardiac function. Fetal Diagn Ther 15, 8–19.CrossRefGoogle ScholarPubMed
Tappia, PS, Liu, S-Y, Shatadal, S, Takeda, N, Dhalla, NS & Panagia, V (1999) Changes in sarcolemmal PLC isoenzymes in postinfarct congestive heart failure: partial correction by imidapril. Am J Physiol 277, H40–H49.Google ScholarPubMed
Udelson, JE, Patten, RD & Konstam, MA (2003) New concepts in post-infarction ventricular remodelling. Rev Cardiovasc Med 4, S3–S12.Google Scholar
Veille, JC, Hanson, R, Sivakoff, M, Hoen, H, Ben-Ami, M (1993) Fetal cardiac size in normal, intrauterine growth retarded, and diabetic pregnancies. Am J Perinatol 10, 275–279.CrossRefGoogle ScholarPubMed
Vijayakumar, M, Fall, CH, Osmond, C & Barker, DJP (1995) Birth weight, weight at one year and left ventricular mass in adult life. Br Heart J 73, 363–367.CrossRefGoogle ScholarPubMed
Vonnahme, KA, Hess, BW & Hansen, TR (2003) Maternal undernutrition from early- to mid-gestation leads to growth retardation, cardiac ventricular hypertrophy and increase liver weight in the fetal sheep. Biol Reprod 69, 133–140.CrossRefGoogle ScholarPubMed
Yang, X-P, Liu, Y-H, Rhaleb, N-E, Kurihara, N, Kim, HE & Carretero, OA (1999) Echocardiographic assessment of cardiac function in conscious and anesthetized mice. Am J Physiol 277, H1967–H1974.Google ScholarPubMed
Yip, G, Wang, M, Zhang, Y, Fung, JWH, Ho, PY & Sanderson, JE (2002) Left ventricular long axis function in diastolic heart failure is reduced in both diastole and systole: time for a redefinition?. Heart 87, 121–125.CrossRefGoogle ScholarPubMed