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Prenatal effects of maternal caffeine intake and dietary high protein on mandibular development in fetal rats

Published online by Cambridge University Press:  09 March 2007

Philip G. Driscoll ,
Fred Joseph JR  and
Tetsuo Nakamoto
Philip G. Driscoll
Affiliation:
Laboratory of Perinatal Nutrition and Metabolism, Departments of Physiology Louisiana State University Medical Center, New Orleans, La 70119, USA
Fred Joseph JR
Affiliation:
Pediatrics, Louisiana State University Medical Center, New Orleans, La 70119, USA
Tetsuo Nakamoto
Affiliation:
Laboratory of Perinatal Nutrition and Metabolism, Departments of Physiology Louisiana State University Medical Center, New Orleans, La 70119, USA
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Abstract

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The purpose of the present study was to determine the effects of caffeine on the mandibles of newborn rats whose dams were given a normal diet (200 g protein/kg diet) compared with those given a high-protein diet (400 g protein/kg diet) during gestation. A total of twenty pregnant Sprague-Dawley rats were randomly divided into four groups of five each. Starting on day 7 of gestation, groups 1 and 2 were fed on control and high-protein diets respectively, and groups 3 and 4 were pair-fed with groups 1 and 2 respectively, but with caffeine added to their diets. The caffeine supplement was 20 mg/kg body-weight. At birth, pups were killed and various measurements of their mandibles were made. The mandibular weights, calcium contents, and alkaline (EC 3.1.3.1) and acid (EC 3.1.3.2) phosphatase activities of the group given the caffeine-supplemented control diet were significantly lower than those of the corresponding unsupplemented group. Alkaline and acid phosphatase activities, collagen synthesis and hydroxyproline contents of the caffeine-supplemented high-protein group were greater than those of the corresponding unsupplemented group, whereas Ca and protein contents of the caffeine-supplemented high-protein group were lower than those of the corresponding unsupplemented group. There were no significant differences in plasma caffeine levels for either dams or pups between the caffeine-supplemented control and high-protein groups. The effects of caffeine on the development of fetal mandibles are apparently modified by different levels of maternal dietary protein.

Keywords

CaffeineMandibular developmentDietary proteinRat
Type
Maternal Nutrition and Metabolism of Offspring
Information
British Journal of Nutrition , Volume 63 , Issue 2 , March 1990 , pp. 285 - 292
Copyright
Copyright © The Nutrition Society 1990

References

Allen, L. H. & Hall, T. E. (1978). Calcium metabolism, intestinal calcium-binding protein and bone growth of rats fed high protein diets. Journal of Nutrition 108, 967–972.CrossRefGoogle ScholarPubMed
Bollet, A. J. (1970). Effect of protein depletion on skin and bone collagen. Mount Sinai Journal of Medicine 38, 445–449.Google Scholar
Butcher, R. W. & Sutherland, E. W. (1962). Adenosine 3',5'-phosphate in biological materials. Journal of Biological Chemistry 237, 1244–1250.CrossRefGoogle Scholar
Chopra, J. G., Forbes, A. K. & Habicht, J. P. (1978). Protein in the U.S. diet. Journal of the American Dietetic Association 72, 253–258.CrossRefGoogle ScholarPubMed
Furuhashi, N., Sato, S., Suzuki, M., Hiruta, M., Tanaka, M. & Takashashi, T. (1985). Effects of caffeine ingestion during pregnancy. Gynecologic and Obstetric Investigation 19, 187–191.CrossRefGoogle ScholarPubMed
Gilbert, E. F. & Pistey, W. R. (1973). Effect on the offspring of repeated caffeine administration to pregnant rats. Journal of Reproduction and Fertility 34, 495–499.CrossRefGoogle ScholarPubMed
Graham, D. (1978). Caffeine - its identity, dietary course and biological effects. Nutrition Reviews 36, 97–102.CrossRefGoogle Scholar
Henderson, G. L. & Schenker, S. (1984). Effects of ethanol and/or caffeine on fetal development and placental amino acid uptake in rats. Developmental Pharmacology and Therapeutics 7, 177–187.CrossRefGoogle ScholarPubMed
Kato, R., Oshima, T. & Tomizawa, S. (1968). Toxicity and metabolism of drugs in relation to dietary protein. Japanase Journal of Pharmacology 18, 356–366.CrossRefGoogle ScholarPubMed
Kim, Y. & Linksweiler, H. M. (1979). Effect of level of protein-intake on calcium metabolism and on parathyroid and renal function in the adult human male. Journal of Nutrition 109, 1399–1404.CrossRefGoogle ScholarPubMed
Kline, O. R. & Christensen, H. D. (1971). Caffeine elimination in late pregnancy. Federation Proceedings 38, 266.Google Scholar
Kuftinec, M. M. & Miller, S. A. (1972). Alkaline and acid phosphatase activities during growth of long bones and mandibles. Calcified Tissue Research 9, 173–178.CrossRefGoogle ScholarPubMed
Lowry, O. H., Rosebrough, N. J., Farr, A. L. & Randall, R. J. (1951). Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry 193, 265–275.CrossRefGoogle ScholarPubMed
Mc Whinnie, D. J. (1975). In vivo effects of mammalian thyrocalcitonin on bone growth and alkaline phosphatase activity in the chick embryo. Comparative Biochemistry and Physiology 50A, 169–175.CrossRefGoogle Scholar
Marks, S. C. (1974). A discrepancy between measurements of bone resorption in vivo and in vitro in newborn osteopetropic rats. American Journal of Anatomy 141, 329–343.CrossRefGoogle ScholarPubMed
Moriguchi, M. & Scott, W. J. Jr (1986). Prevention of caffeine-induced limb malformations by maternal adrenalectomy. Teratology 33, 319–322.CrossRefGoogle ScholarPubMed
Nakamoto, T. & Miller, S. A. (1977). Effects of protein-energy malnutrition on the growth of mandible and long bone in newborn male and female rats. Journal of Nutrition 197, 983–989.CrossRefGoogle Scholar
Nakamoto, T., Rothermel, K. S. & McGrath, K. R. (1987). Biochemical and physical alterations of bones in newborn rats due to excess methionine administered either by gastric intubation or by maternal milk. Archives of Oral Biology 32, 101–105.CrossRefGoogle ScholarPubMed
Nakamoto, T. & Shaye, R. (1986). Protein-energy malnutrition in rats during pregnancy modifies the effects of caffeine on fetal bone. Journal of Nutrition 116, 633–640.CrossRefGoogle Scholar
Newberne, P. M., Gross, R. L. & Roe, D. A. (1978). Drug, toxin and nutrient interactions. World Review of Nutrition and Dietetics 29, 130–169.CrossRefGoogle ScholarPubMed
Nishimura, H. & Nakai, K. (1960). Congenital malformations in offspring of mice treated with caffeine. Proceedings of the Society for Experimental Biology and Medicine 104, 140–145.CrossRefGoogle ScholarPubMed
Phang, S. M. & Downing, S. J. (1973). Amino acid transport in bone: stimulation by cyclic AMP. American Journal of Physiology 24, 191–196.CrossRefGoogle Scholar
Salomon, C. D. (1974). A fine structural study on the extracellular activity of alkaline phosphatase and its role in calcification. Calcified Tissue Research 15, 201–212.CrossRefGoogle Scholar
Scott, W. J. Jr (1983). Caffeine-induced limb malformations: Description of malformations and quantitation of placental transfer. Teratology 28, 427–435.CrossRefGoogle ScholarPubMed
Weiss, R. E., Gorn, A., Durc, S. & Nimni, M. E. (1981). Influence of high protein diet on cartilage and bone formation in rats. Journal of Nutrition 111, 804–816.CrossRefGoogle ScholarPubMed
Yazdani, M., Tran, T. H., Conley, P. M., Laurent, J. Jr & Nakamoto, T. (1987). Effect of protein malnutrition and maternal caffeine intake on the growth of fetal rat brain. Biology of the Neonate 52, 86–92.CrossRefGoogle ScholarPubMed
Yuen, D. E. & Draper, H. H. (1983). Long-term effects of excess protein and phosphorus on bone homeostasis in adult mice. Journal of Nutrition 113, 1374–1380.CrossRefGoogle Scholar