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A preliminary study on the action of cassava on thyroid iodine metabolism in rats

Published online by Cambridge University Press:  09 March 2007

M Van Der velden ,
J Kinthaert ,
S. Orts  and
A. M Ermans
M Van Der velden
Affiliation:
Department of Radioisotopes, Saint Piewe Hospital, Free University of Brussels, Brussels, Belgium
J Kinthaert
Affiliation:
Department of Radioisotopes, Saint Piewe Hospital, Free University of Brussels, Brussels, Belgium
S. Orts
Affiliation:
Department of Nutrition, CEMUBAC-IRSAC, Lwiro, Kivu, Republic of Zaire
A. M Ermans
Affiliation:
Department of Radioisotopes, Saint Pierre Hospital, Free University of Brussels, Brussels, Belgium
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Abstract

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1. The ingestion of cassava (Manihot esculenta Crantz) by rats increased the plasma thiocyanate concentration and reduced the thyroid iodine content and the plasma protein-bound iodine.

2. Administration of increasing doses of thiocyanate raised the plasma thiocyanate concentration and reduced the thyroid iodine content and the plasma protein-bound iodine.

3. In producing these effects, the daily ingestion of 10 g cassava root containing 1·6 mg cyanide was approximately equivalent to a daily intake of about 1–2 mg thiocyanate.

4. These results suggest that the antithyroid action of cassava is the result of the production of thiocyanate by the rat from cyanide arising from the cyanogenic glucosides present in this food.

Type
General Nutrition
Information
British Journal of Nutrition , Volume 30 , Issue 3 , November 1973 , pp. 511 - 517
Copyright
Copyright © The Nutrition Society 1973

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