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Potential modulation of plasma ghrelin and glucagon-like peptide-1 by anorexigenic cannabinoid compounds, SR141716A (rimonabant) and oleoylethanolamide

Published online by Cambridge University Press:  09 March 2007

Patrice D. Cani ,
Maite Lasa Montoya ,
Audrey M. Neyrinck ,
Nathalie M. Delzenne  and
Didier M. Lambert
Patrice D. Cani
Affiliation:
Unité de Pharmacocinétique, Métabolisme, Nutrition et Toxicologie, Ecole de Pharmacie, Université catholique de Louvain, Brussels, Belgium
Maite Lasa Montoya
Affiliation:
Unité de Pharmacocinétique, Métabolisme, Nutrition et Toxicologie, Ecole de Pharmacie, Université catholique de Louvain, Brussels, Belgium Unité de Chimie pharmaceutique et de Radiopharmacie (73.40), Ecole de Pharmacie, Université catholique de Louvain, 73 Avenue E. Mounier, B-1200, Brussels, Belgium
Audrey M. Neyrinck
Affiliation:
Unité de Pharmacocinétique, Métabolisme, Nutrition et Toxicologie, Ecole de Pharmacie, Université catholique de Louvain, Brussels, Belgium
Nathalie M. Delzenne
Affiliation:
Unité de Pharmacocinétique, Métabolisme, Nutrition et Toxicologie, Ecole de Pharmacie, Université catholique de Louvain, Brussels, Belgium
Didier M. Lambert*
Affiliation:
Unité de Chimie pharmaceutique et de Radiopharmacie (73.40), Ecole de Pharmacie, Université catholique de Louvain, 73 Avenue E. Mounier, B-1200, Brussels, Belgium
*
*Corresponding author: Professor D. M. Lambert, fax +32 2 764 73 63, email, [email protected]
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Abstract

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The CB1 cannabinoid receptor antagonist, N-piperidino-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methylpyrazole-3-carboxamide (rimonabant; SR141716A), and oleoylethanolamide (OEA) are known to reduce food consumption, by, at least partially, a peripheral regulation of feeding. The effects of systemic SR141716A or OEA (5 mg/kg) administrations on food consumption in 24 h food-deprived and fed rats were investigated. In fasted rats, SR141716A and OEA produced an inhibition in food intake measurable the first 20 min following injection. The increase in ghrelin levels observed in the vehicle-injected rats was abolished in animals receiving OEA and significantly reduced with SR141716A. Neither OEA nor SR141716A modified glucagon-like peptide-1 (7–36) amide portal levels 20 min after the administration. In fed rats, plasma ghrelin levels of SR141716A- and OEA-treated rats were 35% lower as compared with those of the vehicle-injected rats. These results show an influence of cannabinoid agents on circulating ghrelin levels and suggest that their short-term action on appetite seems to be in accordance with the control of secretion of gastrointestinal orexigenic peptides, mainly expressed in the upper part of the gastrointestinal tract.

Keywords

CannabinoidsGastrointestinal peptidesAppetiteRimonabantOleoylethanolamide
Type
Short communication
Information
British Journal of Nutrition , Volume 92 , Issue 5 , November 2004 , pp. 757 - 761
Copyright
Copyright © The Nutrition Society 2004

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