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Polyunsaturated fatty acids and conjugated linoleic acid isomers in breast milk are associated with plasma non-esterified and erythrocyte membrane fatty acid composition in lactating women

Published online by Cambridge University Press:  08 March 2007

Alexandre G. Torres ,
Jacqueline G. Ney ,
Flávia Meneses  and
Nádia M. F. Trugo
Alexandre G. Torres*
Affiliation:
Universidade Federal do Rio de Janeiro, Cidade Universitária, Laboratório de Bioquímica Nutricional e de Alimentos, Instituto de Química, CT/ Bl. A, 21949–900, Rio de JaneiroBrazil
Jacqueline G. Ney
Affiliation:
Universidade Federal do Rio de Janeiro, Cidade Universitária, Laboratório de Bioquímica Nutricional e de Alimentos, Instituto de Química, CT/ Bl. A, 21949–900, Rio de JaneiroBrazil
Flávia Meneses
Affiliation:
Universidade Federal do Rio de Janeiro, Cidade Universitária, Laboratório de Bioquímica Nutricional e de Alimentos, Instituto de Química, CT/ Bl. A, 21949–900, Rio de JaneiroBrazil
Nádia M. F. Trugo
Affiliation:
Universidade Federal do Rio de Janeiro, Cidade Universitária, Laboratório de Bioquímica Nutricional e de Alimentos, Instituto de Química, CT/ Bl. A, 21949–900, Rio de JaneiroBrazil
*
*Corresponding authorDr Alexandre G. Torres, fax +55 21 2562 7266, email [email protected]
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Abstract

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Maternal adipose tissue is a major contributor to breast milk long-chain fatty acids, probably through the pool of plasma NEFA. The fatty acid composition of the erythrocyte membrane (EM) is a biochemical index of the intake of fatty acids not synthesized endogenously and of PUFA and long-chain PUFA fatty acid status. The present study investigated the associations between breast milk fatty acid composition and the composition of plasma NEFA and of EM fatty acids with special reference to PUFA, long-chain PUFA and conjugated linoleic acid (CLA). The detailed fatty acid composition of mature breast milk was also reported. Thirty-three healthy, lactating Brazilian women donated milk samples; of these, twenty-four also donated blood samples in an observational cross-sectional study. Breast milk fatty acid composition presented several associations with NEFA and EM composition, which explained most (≥50%) of the variability of selected milk PUFA, long-chain PUFA and CLA. Milk CLA was associated with fatty acids that are markers of dairy fat intake in the diet, NEFA and EM. In general, breast milk n-3 fatty acids and CLA, but not n-6 fatty acids, were associated with EM composition, whereas both the n-6 and n-3 fatty acids and CLA in milk were associated with NEFA composition, possibly owing to its role as a direct source of fatty acids for breast milk. These findings emphasize the contribution of the NEFA pool derived from the adipose tissue to the long-chain fatty acid composition of breast milk.

Keywords

Fatty acid metabolismNon-esterified fatty acidsErythrocyte fatty acidsLactation
Type
Research Article
Information
British Journal of Nutrition , Volume 95 , Issue 3 , March 2006 , pp. 517 - 524
Copyright
Copyright © The Nutrition Society 2006

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