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Plasma phylloquinone (vitamin K1) concentration and its relationship to intake in a national sample of British elderly people

Published online by Cambridge University Press:  09 March 2007

C. W. Thane ,
C. J. Bates ,
M. J. Shearer ,
N. Unadkat ,
D. J. Harrington ,
A. A. Paul ,
A. Prentice  and
C. Bolton-Smith
C. W. Thane*
Affiliation:
MRC Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge CB1 9NL, UK
C. J. Bates
Affiliation:
MRC Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge CB1 9NL, UK
M. J. Shearer
Affiliation:
Vitamin K Research & Diagnostic Units, Haemophilia Centre, St Thomas' Hospital, London SE1 7EH, UK
N. Unadkat
Affiliation:
Vitamin K Research & Diagnostic Units, Haemophilia Centre, St Thomas' Hospital, London SE1 7EH, UK
D. J. Harrington
Affiliation:
Vitamin K Research & Diagnostic Units, Haemophilia Centre, St Thomas' Hospital, London SE1 7EH, UK
A. A. Paul
Affiliation:
MRC Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge CB1 9NL, UK
A. Prentice
Affiliation:
MRC Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge CB1 9NL, UK
C. Bolton-Smith
Affiliation:
MRC Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge CB1 9NL, UK
*
*Corresponding author:Mr C. W. Thane, fax +44 1223 437515, email [email protected]
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Abstract

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Plasma phylloquinone (vitamin K1) concentration was examined according to season, socio-demographic and lifestyle factors and phylloquinone intake in a nationally representative sample of British people aged 65 years and over from the 1994–5 National Diet and Nutrition Survey. Values for both plasma phylloquinone concentration and phylloquinone intake were available from 1076 participants (561 men, 515 women). Eight hundred and thirty-four were living in private households, 242 in residential or nursing homes. Weighted geometric mean plasma phylloquinone concentrations were 0·36 (95 % CI 0·06, 2·01) and 0·24 (95 % CI 0·06, 0·96) nmol/l in free-living and institution samples respectively. Plasma phylloquinone concentrations did not generally differ between men and women, although values in free-living people were significantly lower during autumn and winter (October to March). Plasma phylloquinone concentration was not significantly associated with age. Plasma phylloquinone concentrations were positively correlated with phylloquinone intake in free-living men and women (r 0·18 and 0·30 respectively, both P<0·001). Stepwise multiple regression analysis found that 11 % of the variation in plasma phylloquinone concentration was explained by phylloquinone intake, season and plasma triacylglycerol concentration. After adjustment for age and corresponding nutrient intakes, plasma phylloquinone concentration was significantly associated (each P<0·01) with plasma concentrations of triacylglycerol, cholesterol, retinol and 25-hydroxyvitamin D in free-living women but not men, and with plasma concentrations of carotenes, α- and γ-tocopherols and lutein in free-living men and women. The possibility of concurrent low fat-soluble vitamin status in elderly populations may be a cause for concern.

Keywords

Vitamin K statusDietary intakeFat-soluble vitamins
Type
Research Article
Information
British Journal of Nutrition , Volume 87 , Issue 6 , June 2002 , pp. 615 - 622
Copyright
Copyright © The Nutrition Society 2002

References

Binkley, NC & Suttie, JW (1995) Vitamin K nutrition and osteoporosis. Journal of Nutrition 125, 1812–1821.CrossRefGoogle ScholarPubMed
Bolton-Smith, C, Mole, PA, McMurdo, MET & Shearer, MJ (2001) Two-year intervention with phylloquinone (vitamin K1), vitamin D and calcium: effect on bone mineral content of older women. Annals of Nutrition and Metabolism 45, Suppl. 1, 246, AbstrGoogle Scholar
Bolton-Smith, C, Price, RJG, Fenton, ST, Harrington, DJ & Shearer, MJ (1998) The relationship between plasma and dietary phylloquinone (vitamin K1) in Scottish adults. Proceedings of the Nutrition Society 57, 148AGoogle Scholar
Bolton-Smith, C, Price, RJG, Fenton, ST, Harrington, DJ & Shearer, MJ (2000) Compilation of a provisional UK database for the phylloquinone (vitamin K1) content of foods. British Journal of Nutrition 83, 389–399.Google ScholarPubMed
Booth, SL, Lichtenstein, AH, O'Brien-Morse, M, McKeown, NM, Wood, RJ, Saltzman, E & Gundberg, CM (2001) Effects of a hydrogenated form of vitamin K on bone formation and resorption. American Journal of Clinical Nutrition 74, 783–790.CrossRefGoogle ScholarPubMed
Booth, SL, Sokoll, LJ, O'Brien, ME, Tucker, K, Dawson-Hughes, B & Sadowski, JA (1995) Assessment of dietary phylloquinone intake and vitamin K status in postmenopausal women. European Journal of Clinical Nutrition 49, 832–841.Google ScholarPubMed
Booth, SL, Tucker, KL, McKeown, NM, Davidson, KW, Dallal, GE & Sadowski, JA (1997) Relationships between dietary intakes and fasting plasma concentrations of fat-soluble vitamins in humans. Journal of Nutrition 127, 587–592.CrossRefGoogle ScholarPubMed
Conly, JM, Stein, K, Worobetz, L & Rutledge-Harding, S (1994) The contribution of vitamin K2 (menaquinones) produced by intestinal microflora to human nutritional requirements for vitamin K. American Journal of Gastroenterology 89, 915–923.Google ScholarPubMed
Davidson, KW & Sadowski, JA (1997) Determination of vitamin K compounds in plasma or serum by high-performance liquid chromatography using postcolumn chemical reduction and fluorimetric detection. Methods in Enzymology 282, 408–421.CrossRefGoogle ScholarPubMed
Fenton, ST, Bolton-Smith, C, Harrington, D & Shearer, MJ (2000) Intra- and inter-individual variability and lack of seasonal variation of plasma phylloquinone (vitamin K1) for Scottish men and women. Proceedings of the Nutrition Society 59, 32AGoogle Scholar
Ferland, G (1999) The vitamin K-dependent proteins: an update. Nutrition Reviews 56, 223–230.CrossRefGoogle Scholar
Ferland, G, Sadowski, J & O'Brien, M (1993) Dietary induced sub-clinical vitamin K deficiency in normal human subjects. Journal of Clinical Investigation 91, 1761–1768.CrossRefGoogle Scholar
Finch, S, Doyle, W, Lowe, C, Bates, CJ, Prentice, A, Smithers, G & Clarke, PC (1998) National Diet and Nutrition Survey: People Aged 65 Years and Over, vol. 1. Report of the Diet and Nutrition Survey. London: The Stationery Office.Google Scholar
Haroon, Y, Bacon, DS & Sadowski, JA (1986) Liquid-chromatographic determination of vitamin K1 in plasma with fluorimetric detection. Clinical Chemistry 32, 1925–1929.CrossRefGoogle Scholar
Kohlmeier, M, Salomon, A, Saupe, J & Shearer, MJ (1996) Transport of vitamin K to bone in humans. Journal of Nutrition 126, 1192S–1196S.CrossRefGoogle ScholarPubMed
Lamon-Fava, S, Sadowski, JA, Davidson, KW, O'Brien, ME, McNamara, JR & Schaefer, EJ (1998) Plasma lipoproteins as carriers of phylloquinone (vitamin K1) in humans. American Journal of Clinical Nutrition 67, 1226–1231.CrossRefGoogle ScholarPubMed
Luo, G, Ducy, P, McKee, MD, Pinero, GJ, Loyer, E, Behringer, RR & Karsenty, G (1997) Spontaneous calcification of arteries and cartilage in mice lacking matrix Gla protein. Nature 386, 78–81.CrossRefGoogle ScholarPubMed
McCarthy, PT, Harrington, DJ & Shearer, MJ (1997) Assay of phylloquinone in plasma by high-performance liquid chromatography with electrochemical detection. Methods in Enzymology 282, 421–433.CrossRefGoogle ScholarPubMed
Rock, CL, Thornquist, MD, Kristal, AR, Patterson, RE, Cooper, DA, Neuhouser, ML, Neumark-Sztainer, D & Cheskin, LJ (1999) Demographic, dietary and lifestyle factors differentially explain variability in serum carotenoids and fat-soluble vitamins: Baseline results from the sentinel site of the Olestra Post-Marketing Surveillance Study. Journal of Nutrition 129, 855–864.CrossRefGoogle ScholarPubMed
Sadowski, JA, Hood, SJ, Dallal, GE & Garry, PJ (1989) Phylloquinone in plasma from elderly and young adults: factors influencing its concentration. American Journal of Clinical Nutrition 50, 100–108.CrossRefGoogle Scholar
Sakamoto, N, Nishiike, T, Iguchi, H & Sakamoto, K (1999) The effect of diet on blood vitamin K status and urinary mineral excretion assessed by a food questionnaire. Nutrition and Health 13, 1–10.CrossRefGoogle ScholarPubMed
Schurgers, LJ, Geleijnse, JM, Grobbee, DE, Pols, HAP, Hofman, A, Witteman, JCM & Vermeer, C (1999) Nutritional intake of vitamins K1 (phylloquinone) and K2 (menaquinone) in the Netherlands. Journal of Nutritional and Environmental Medicine 9, 115–122.CrossRefGoogle Scholar
Shearer, MJ (1991) Vitamin nutriture methodology: phylloquinone (vitamin K1) in serum or plasma by HPLC. In Nutritional Status Assessment: a Manual for Population Studies, pp. 214–220 [Fidanza, F, editor]. London: Chapman & Hall.Google Scholar
Shearer, MJ (1992) Vitamin K metabolism and nutriture. Blood Reviews 6, 92–104.CrossRefGoogle ScholarPubMed
Shearer, MJ (1997) The roles of vitamins D and K in bone health and osteoporosis prevention. Proceedings of the Nutrition Society 56, 915–937.CrossRefGoogle Scholar
Shearer, MJ (2000 a) Role of vitamin K and Gla proteins in the pathophysiology of osteoporosis and vascular calcification. Current Opinion in Clinical Nutrition and Metabolic Care 3, 433–438.CrossRefGoogle ScholarPubMed
Shearer, MJ (2000 b) Vitamin K (phylloquinone and menaquinones). In Human Nutrition and Dietetics, 10th ed., pp. 236–247 [Garrow, JS, James, WPT and Ralph, A, editors]. Edinburgh: Churchill Livingstone.Google Scholar
Sokoll, LJ, Booth, SL, O'Brien, ME, Davidson, KW, Tsaioun, KI & Sadowski, JA (1997) Changes in serum osteocalcin, plasma phylloquinone, and urinary γ-carboxyglutamic acid in response to altered intakes of dietary phylloquinone in human subjects. American Journal of Clinical Nutrition 65, 779–784.CrossRefGoogle ScholarPubMed
Sokoll, LJ & Sadowski, JA (1996) Comparison of biochemical indexes for assessing vitamin K status in a healthy adult population. American Journal of Clinical Nutrition 63, 566–573.CrossRefGoogle Scholar
Suttie, JW (1995) The importance of menaquinones in human nutrition. Annual Review of Nutrition 15, 399–417.CrossRefGoogle ScholarPubMed
Suttie, JW, Mummah-Schendel, LL, Shah, DV, Lyle, BJ & Greger, JL (1988) Vitamin K deficiency from dietary vitamin K restriction in humans. American Journal of Clinical Nutrition 47, 475–480.CrossRefGoogle ScholarPubMed
Szulc, P, Chapuy, MC, Meunier, PJ & Delmas, PD (1993) Serum undercarboxylated osteocalcin is a marker of the risk of hip fracture in elderly women. Journal of Clinical Investigation 91, 1769–1774.CrossRefGoogle ScholarPubMed
Tamatani, M, Morimoto, S, Nakajima, M, Fukuo, K, Onishi, T, Kitano, S, Niinobu, T & Ogihara, T (1998) Decreased circulating levels of vitamin K and 25-hydroxyvitamin D in osteopenic elderly men. Metabolism 47, 195–199.CrossRefGoogle ScholarPubMed
Thane, CW, Paul, AA, Bates, CJ, Bolton-Smith, C, Prentice, A & Shearer, MJ (2002) Intake and sources of phylloquinone (vitamin K1): variation with socio-demographic and lifestyle factors in a national sample of British elderly people. British Journal of Nutrition 87, 605–613.CrossRefGoogle Scholar