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Plasma carotenoid concentrations in relation to acute respiratory infections in elderly people

Published online by Cambridge University Press:  09 March 2007

Judith M. van der Horst-Graat ,
Frans J. Kok  and
Evert G. Schouten
Judith M. van der Horst-Graat
Affiliation:
Division of Human Nutrition and Epidemiology, Wageningen UniversityBomenweg 2, P.O. Box 8129, 6703 HD, Wageningen, The Netherlands
Frans J. Kok
Affiliation:
Division of Human Nutrition and Epidemiology, Wageningen UniversityBomenweg 2, P.O. Box 8129, 6703 HD, Wageningen, The Netherlands
Evert G. Schouten*
Affiliation:
Division of Human Nutrition and Epidemiology, Wageningen UniversityBomenweg 2, P.O. Box 8129, 6703 HD, Wageningen, The Netherlands
*
*Corresponding author: fax +31 317 482782, Email [email protected]
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Abstract

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A high plasma carotenoid concentration could improve the immune response and result in decreased risk of infectious diseases. However, data on the relationship of plasma carotenoid concentration with acute respiratory infections, which occur frequently in elderly people, are scarce. We investigated, therefore, the relationship of plasma concentrations of six major carotenoids (β-carotene, α-carotene, β-cryptoxanthin, lycopene, lutein and zeaxanthin) with the incidence and severity of acute respiratory infections. Baseline data from an intervention trial were used. Participants were 652 non-institutionalized elderly people (≥60 years old) enrolled via two community-based sampling strategies in the Wageningen area of The Netherlands in 1998–99. Plasma carotenoid concentrations were divided into quartiles, the lowest being the reference. Frequency and severity of episodes during the previous 1 year, i.e. staying in bed, medical consultation and episode-related medication, were self-reported by means of a questionnaire. On average 1·6 episodes per person were recorded. The incidence rate ratio of acute respiratory infections at high β-carotene status was 0·71 (95% CI 0·54–0·92) as compared with the low β-carotene concentration group. No association was observed between β-carotene and illness severity. α-Carotene, β-cryptoxanthin, lycopene, lutein and zeaxanthin were not related to incidence or severity of the infections. We conclude that elderly people with a high plasma β-carotene concentration may have a lower occurrence of acute respiratory infections.

Keywords

Acute respiratory infectionCarotenoidsElderly people
Type
Research Article
Information
British Journal of Nutrition , Volume 92 , Issue 1 , July 2004 , pp. 113 - 118
Copyright
Copyright © The Nutrition Society 2004

References

1Aebischer, CP, Schierle, J & Schuep, WSimultaneous determination of retinol, tocopherols, carotene, lycopene, and xanthophylls in plasma by means of reversed-phase high-performance liquid chromatography Methods Enzymol 1999 299 348–362CrossRefGoogle ScholarPubMed
2Broekmans, WMR, Klopping, KI, Schuurman, CRWC,Verhagen, H, Van-den Berg, H,Kok, FJ & Van Poppel, GFruits and vegetables increase plasma carotenoids and vitamins and decrease homocysteine in humans J Nutr 2000 130 1578–1583CrossRefGoogle ScholarPubMed
3Carrat, F, Tachet, A, Rouzioux, C, Housset, B & Valleron, AJEvaluation of clinical case definitions of influenza, detailed investigation of patients during the 1995–1996 epidemic in France Clin Infect Dis 1999 28 283–290CrossRefGoogle ScholarPubMed
4Corridan, BM, O'Donoghue, M, Hughes, DA & Morrissey, PALow-dose supplementation with lycopene or beta-carotene does not enhance cell-mediated immunity in healthy free-living elderly humans Eur J Clin Nutr 2001 55 627–635CrossRefGoogle Scholar
5Daudu, PA, Kelley, DS, Taylor, PC,Burri, BJ & Wu, MMEffect of a low beta-carotene diet on the immune functions of adult women Am J Clin Nutr 1994 60 969–969CrossRefGoogle ScholarPubMed
6Falsey, AR, McCann, RM, Hall, WJ,Tanner, MA,Criddle, MM,Formica, MA,Irvine, CS,Kolassa, JE,Barker, WH & Treanor, JJAcute respiratory tract infection in daycare centers for older persons J Am Geriatr Soc 1995 43 30–36CrossRefGoogle ScholarPubMed
7Fortes, C, Forastiere, F, Agabiti, NThe effect of zinc and vitamin A supplementation on immune response in an older population J Am Geriatr Soc 1998 46 19–26CrossRefGoogle Scholar
8Fuller, CJFaulkner, H, Bendich, A,Parker, RS & Roe, DAEffect of beta-carotene supplementation on photosuppression of delayed-type hypersensitivity in normal young men Am J Clin Nutr 1992 56 684690CrossRefGoogle ScholarPubMed
9Graat, JM, Schouten, EG & Kok, FJGrievink L de-Waart FG Schouten EG Kok FJ (2000) Serum carotenoids, alpha-tocopherol, and lung function among Dutch elderly Am J Respir Crit Care Med 2000 161 790–795Google Scholar
10Grievink, L, de-Waart, FG, Schouten, EG & Kok, FJSerum carotenoids, alpha-tocopherol, and lung function among Dutch elderly Am J Respir Crit Care Med 2000 161 790–795CrossRefGoogle ScholarPubMed
11Haller, J, Weggemans, RM, Lammi, KC & Ferry, MChanges in the vitamin status of elderly Europeans: plasma vitamins A, E, B-6, B-12, folic acid and carotenoids. SENECA Investigators Eur J Clin Nutr 1996 50Suppl. 2 S32–S46Google Scholar
12Hemila, H, Kaprio, J, Albanes, D, Heinonen, OP & Virtamo, JVitamin C, vitamin E, and beta-carotene in relation to common cold incidence in male smokers Epidemiology 2002 13 32–37CrossRefGoogle ScholarPubMed
13Hess, D, Keller, HE, Oberlin, B,Bonfanti, R & Schuep, WSimultaneous determination of retinol, tocopherols, carotenes and lycopene in plasma by means of high-performance liquid chromatography on reversed phase Int J Vitam Nutr Res 1991 61 232–238Google ScholarPubMed
14Hughes, DADietary carotenoids and human immune function Nutrition 2001 17 823–827CrossRefGoogle ScholarPubMed
15Hughes, DA, Wright, AJA, Finglas, PM, Polley, AC, Bailey, AL, Astley, SB & Southon, SEffects of lycopene and lutein supplementation on the expression of functionally associated surface molecules on blood monocytes from healthy male nonsmokers J Infect Dis 2000 182 Suppl. 1S11–S15CrossRefGoogle ScholarPubMed
16Jansen, CJFFruits and Vegetables and the Risk of Epithelial Cancer.PhD Thesis Wageningen University 2001Google Scholar
17Jyonouchi, H, Sun, S, Mizokami, M & Gross, MDEffects of various carotenoids on cloned, effector-stage T-helper cell activity Nutr Cancer 1996 26 313324CrossRefGoogle ScholarPubMed
18Khachik, F, Beecher, GR & Smith, JCJLutein, lycopene, and their oxidative metabolites in chemoprevention of cancer J Cell Biochem 1996 22 236246Google Scholar
19Miller, RAThe aging immune system: primer and prospectus Science 1996 273 70–74CrossRefGoogle ScholarPubMed
20Murata, T, Tamai, H, Morinobu, T, Manago, M, Takenaka, H, Hayashi, K & Mino, MEffect of long-term administration of beta-carotene on lymphocyte subsets in humans Am J Clin Nutr 1994 60 597&602CrossRefGoogle ScholarPubMed
21Murphy, S, West-KP, J, Greenough, WB,Cherot, E, Katz, J & Clement, LImpact of vitamin A supplementation on the incidence of infection in elderly nursing-home residents: a randomized controlled trial Age Ageing 1992 21 435–439CrossRefGoogle ScholarPubMed
22Nicholson, KG, Kent, J, Hammersley, V & Cancio, EAcute viral infections of upper respiratory tract in elderly people living in the community: comparative, prospective, population based study of disease burden Br Med J 1997 315 1060–1064CrossRefGoogle ScholarPubMed
23Redlich, CA, Blaner, WS, Van-Bennekum, AM,Chung, JS, Clever, SL, Holm, CT &Cullen, MREffect of supplementation with beta-carotene and vitamin A on lung nutrient levels Cancer Epidemiol Biomarkers Prev 1998 7 211–214Google ScholarPubMed
24Redlich, CAGrauer, JN, Van-Bennekum, AM,Clever, SL,Ponn, RB & Blaner, WSCharacterization of carotenoid, vitamin A, and alpha-tocopheral levels in human lung tissue and pulmonary macrophages Am J Respir Crit Care Med 1996 154 1436–1443CrossRefGoogle ScholarPubMed
25Ringer, TV, DeLoof, MJWinterrowd, GE, Francom, SF, Gaylor, SK, Ryan, JA, Sanders, ME & Hughes, GSBeta-carotene's effects on serum lipoproteins and immunologic indices in humans Am J Clin Nutr 1991 53 688694CrossRefGoogle ScholarPubMed
26Rock, CL, Flatt, SW, Wright, FA,, ,Faerber, S,Newman, V,Kealey, S & Pierce, JPResponsiveness of carotenoids to a high vegetable diet intervention designed to prevent breast cancer recurrence Cancer Epidemiol Biomarkers Prev 1997 6 617–623Google ScholarPubMed
27Santos, MS, Leka, LS, Ribaya-Mercado, JD,Russell, RM, Meydani, M, Hennekens, CHGaziano, JM & Meydani, SNShort- and long-term beta-carotene supplementation do not influence T cell-mediated immunity in healthy elderly persons Am J Clin Nutr 1997 66 917–924CrossRefGoogle Scholar
28Santos, MS, Meydani, SN, Leka, L,Wu, D,Fotouhi, N,Meydani, M,Hennekens, CH & Gaziano, JMNatural killer cell activity in elderly men is enhanced by beta-carotene supplementation Am J Clin Nutr 1996 64 772–777CrossRefGoogle ScholarPubMed
29Schmitz, HH, Poor, CL, Wellman, RB & Erdman, JWConcentrations of selected carotenoids and vitamin A in human liver, kidney and lung tissue J Nutr 1991 121 1613–1621CrossRefGoogle ScholarPubMed
30Semba, RDVitamin A, immunity, and infection Clin Infect Dis 1994 19 489–499CrossRefGoogle ScholarPubMed
31Tannock, GA, Reid, AL & Gillett, SMA study of respiratory infections in a healthy adult population during the 1987 Australian winter Fam Pract 1987 10 378–386CrossRefGoogle Scholar
32Thurnham, DICarotenoids, functions and fallacies Proc Nutr Soc 1994 53 77&87CrossRefGoogle ScholarPubMed
33Tucker, KL, Chen, H, Vogel, S,Wilson, PW, Schaefer, EJ & Lammi-Keefe, CJCarotenoid intakes, assessed by dietary questionnaire, are associated with plasma carotenoid concentrations in an elderly population J Nutr 1999 129 438–445CrossRefGoogle Scholar
34Van-Kappel, AL, Steghens, JP, Zeleniuch-Jacquotte, A,Chajes, V,Toniolo, P & Riboli, ESerum carotenoids as biomarkers of fruit and vegetable consumption in the New York Women's Health Study Public Health Nutr 2001 4 829835CrossRefGoogle ScholarPubMed
35Van-Poppel, G, Spanhaak, S & Ockhuizen, TEffect of beta-carotene on immunological indexes in healthy male smokers Am J Clin Nutr 1993 57 402–407CrossRefGoogle ScholarPubMed
36Vogel, S, Contois, JH, Tucker, KL,Wilson, PW,Schaefer, EJ & Lammi, KCPlasma retinol and plasma and lipoprotein tocopherol and carotenoid concentrations in healthy elderly participants of the Framingham Heart Study Am J Clin Nutr 1997 66 950–958CrossRefGoogle ScholarPubMed
37Vuilleumier, JP & Keck, EFluorometric assay of vitamin C in biological materials using a centrifugal analyser with fluorescence attachment J Micronutr Anal 1989 5 25–34Google Scholar
38Watson, RR, Prabhala, RH, Plezia, PM & Alberts, DSEffect of beta-carotene on lymphocyte subpopulations in elderly humans: evidence for a dose–response relationship. published erratum appears in Am J Clin Nutr 1991 53 90–94CrossRefGoogle ScholarPubMed
39Watzl, B, Bub, A, Blockhaus, M,Herbert, BM,Luhrmann, PM,Neuhauser-Berthold, M & Rechkemmer, GProlonged tomato juice consumption has no effect on cell-mediated immunity of well-nourished elderly men and women J Nutr 2000 130 1719–1723CrossRefGoogle ScholarPubMed
40Watzl, B, Bub, A, Brandstetter, BR & Rechkemmer, GModulation of human T-lymphocyte functions by the consumption of carotenoid-rich vegetables Br J Nutr 1999 82 383–389CrossRefGoogle ScholarPubMed